Association among basal serum BDNF, cardiorespiratory fitness and cardiovascular disease risk factors in untrained healthy Korean men

Jung, Soo Yeon; Kim, Jong-Kyu; Davis, Jennifer R.; Blair, Steven N.; Hyun-Chul, Cho

doi:10.1007/s00421-010-1658-5

Cited by 71 publications

(62 citation statements)

References 44 publications

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“…Additionally, greater physical activity and cardiovascular fitness are related to reduced systemic inflammation and circulating biomarkers (e.g. brain derived neurotrophic factor (BDNF) [61], leptin [62], ghrelin [63]) which are implicated in obesity and related to cognitive dysfunction. Finally, increased physical activity levels are likely related to improved cognitive function through their association with improved structural and functional brain outcomes [25][26][27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Physical activity and cognitive function in bariatric surgery candidates

Galioto¹,

King²,

Bond³

et al. 2014

International Journal of Neuroscience

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Cognitive impairment is common in severe obesity. Lack of physical activity is a likely contributor to impairment in this population, as many obese persons are inactive and physical activity has been positively and independently associated with cognitive function in healthy and medically-ill samples. This study investigated whether physical activity, measured by self-report of aerobic physical activity in 85 bariatric surgery candidates, was associated with cognitive function. A subset of 31 participants also completed objective activity monitoring. Steps/d and high-cadence min/week, representative of ambulatory moderate to vigorous physical activity (MVPA), were calculated. Approximately one quarter of participants self-reported at least 30 min/d of aerobic MVPA, at least 5 d/week. Median steps/d was 7949 (IQR = 4572) and median MVPA min/week was 105 (IQR = 123). Cognitive deficits were found in 32% of participants (29% memory, 10% executive function, 13% language, 10% attention). Controlling for demographic and medical factors, self-reported aerobic physical activity was weakly correlated with lower attention (r = -0.21, p = 0.04) and executive function (r = -0.27, p < 0.01) and both self-reported aerobic physical activity and objectively-determined MVPA min/week were negatively correlated with memory (r = -0.20, p = 0.04; r = -0.46; p = 0.02, respectively). No other correlations between physical activity measures and cognitive function were significant. Contrary to expectations, greater levels of physical activity were not associated with better cognitive functioning. Such findings encourage future studies to clarify the association among cognitive function and physical activity in obese persons.

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Section: Discussionmentioning

confidence: 99%

Physical activity and cognitive function in bariatric surgery candidates

Galioto¹,

King²,

Bond³

et al. 2014

International Journal of Neuroscience

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“…Interestingly, plasma BDNF level was detected as an independent predictor of 4-year coronary and all-cause mortality, indicating that low plasma BDNF may be associated with future coronary events and death in these patients. An inverse relationship between serum BDNF level and the status of cardiorespiratory fitness was also reported (17), suggesting serum BDNF may be associated with the effects of increased cardiorespiratory fitness on cardiovascular disease. Future studies are needed to elucidate the exact roles of BDNF and its receptor in cardiac homeostasis and injury.…”

Section: Bdnf Blood Level and Its Associatesmentioning

confidence: 78%

“…Circulating BDNF was reported to correlate positively to LDL cholesterol, total cholesterol and triglyceride levels in humans (16,17). In animal experiments, BDNF treatment reported to lower blood glucose, non-esterified free fatty acid, total cholesterol and phospholipid levels significantly in diabetic models, along with liver weight, liver triglyceride contents and fatty liver in histological examinations (28).…”

Section: Bdnf Blood Level and Its Associatesmentioning

confidence: 99%

“…In a study in which the subjects were screened for long years starting from a healthy period, circulating BDNF level was higher in women and it decreased with advancing age in both genders (16). Moreover, blood level of BDNF had a positive correlation with diastolic blood pressure, total cholesterol, lowdensity lipoprotein cholesterol, adipose tissue mass, body mass index, diastolic blood pressure and triglyceride, showing some differences between men and women (16,17). Importantly, women with low plasma BDNF had greater all-cause mortality risk than women with high plasma BDNF in a study conducted in old age individuals (18).…”

Section: Bdnf Blood Level and Its Associatesmentioning

confidence: 99%

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Brain derived neurotrophic factor (BDNF) in cardiometabolic physiology and diseases

Taşçı¹,

Kabul²,

Aydoğdu³

2012

Anadolu Kardiyol Derg

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Important advances in our understanding of the relationships between adipose tissue derived peptides, namely adipokines, and their effects on cardiovascular functions have been achieved in recent years. Growing knowledge of adipokine biology is revealing the complexity of these proteins. Adipose tissue releases some other proteins called neurotrophins that are mainly active in central and peripheral nervous system. However, secretion and activity of these hormones are not only limited to neuronal cells and tissues, but they also take part in adipose tissue development, energy metabolism, glucose utilization, insulin sensitivity, inflammation, lipoprotein synthesis, and atherosclerosis. In this review, we describe the most recent advances in the functions of brain derived nerve growth factor (BDNF), a major type of neurotrophins, focusing primarily on cardiovascular and metabolic diseases. (Anadolu Kardiyol Derg 2012; 12: 684-8) Key words: Brain derived nerve growth factor, cardiovascular disease, atherosclerosis, dyslipidemia, diabetes mellitus Review Derleme 684ÖZET Son yıllarda, adipokinler olarak bilinen adipoz doku kaynaklı peptidler ve bunların kardiyovasküler fonksiyonlar üzerine etkileri üzerine önemli ilerlemeler sağlanmıştır. Adipokin biyolojisi hakkında bilgiler çoğaldıkça bu proteinlerin karmaşık görünümü aydınlatılmaktadır. Adipoz doku nörotrofin-ler olarak bilinen ve temel olarak santral ve periferal sinir sisteminde görev yapan diğer bazı proteinleri de salgılar. Bununla beraber, bu hormonların sekresyon ve aktivitesi sadece nöronal hücreler ve dokularla sınırlı olmayıp yağ dokusu gelişimi, enerji metabolizması, glikoz kullanımı, insülin duyarlılığı, enflamasyon, lipoprotein sentezi ve aterosklerozda da rol oynarlar. Bu derlemede majör bir nörotrofin olan beyinden türemiş nörotrofik faktör (BDNF) ile ilgili en son veriler, özellikle kardiyovasküler ve metabolik hastalıklar üzerinden irdelenmiştir.

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“…Studies have also shown inverse correlation between plasma BDNF and circulating blood lipid concentrations including TG, cholesterol and LDL-c (Golden et al, 2010, Jung et al, 2011, Jiang et al, 2011. BDNF has been shown to lower plasma NEFA, TC and blood glucose in mice (Tsuchida et al, 2002).…”

Section: Neurotrophins and N-3 Pufa: Brain And Heart Connectionmentioning

confidence: 99%

Lipid metabolism and the risk factors of cardiovascular disease: implication of dietary omega-3 polyunsaturated fatty acids

Balogun

2016

Appl. Physiol. Nutr. Metab.

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Cardiovascular disease (CVD) is a complicated and multifarious disease, and is the number cause of mortality worldwide. The pathogenesis of CVD is attributed to the interaction between genetics and environment. There are numerous data that support the cardioprotective properties of omega (n)-3 polyunsaturated fatty acids (PUFA); however, there are also controversial reports. Considering the reported sex and age differences in the pathophysiology of CVD and the metabolism of n-3 PUFA, it is imperative to consider these factors in the cardioprotective effects of n-3 PUFA. The main objective of the current thesis was to investigate the effects of n-3 PUFA on the risk factors of CVD such as dyslipidaemia and obesity, with particular focus on how sex, age and dose of n-3 PUFA affect lipid and lipoprotein metabolism. The set of experiments presented in this thesis was investigated using the C57BL/6 mouse strain which has been established as a mouse model of choice for the study of diet-induced pathological conditions of lipid and lipoprotein metabolism. Plasma concentrations of lipids and lipoproteins of mice offspring at weaning and 16 weeks postweaning were chosen as study outcomes to assess the sex, age and dose-specific effects of n-3 PUFA on markers of dyslipidaemia, a well-known risk factor of CVD. It was observed that a longer exposure to a postnatal diet high in n-3 PUFA increased plasma concentration of low-density lipoprotein cholesterol (LDL-c) in the offspring in a sex-specific manner; however, the profile of this increase was less atherogenic , as the high n-3 PUFA group had a lower plasma concentration of very small LDL-particles in both males and females. There was no effect of high n-3 PUFA diet observed on plasma concentration of highdensity lipoprotein cholesterol (HDL-c); however, the high n-3 PUFA group had a higher cholesterol efflux in the male offspring but not in female offspring, further demonstrating the effect of sex on cholesterol metabolism. Lipidomic analyses revealed that high n-3 PUFA diet iii led to higher hepatic and plasma concentrations of n-3 PUFA-containing bioactive lipids such a phosphatidylcholine, lysophosphatidylcholine and free fatty acids, which could positively influence pathways involved in cardioprotection. The effects of dietary n-3 PUFA on obesity at the cellular level was also investigated, using adipocyte hypertrophy as the outcome measure of adipose tissue enlargement. A diet high in n-3 PUFA prevented adipocyte hypertrophy in males, with no effect in females. High n-3 PUFA diet also led to the downregulation of the mRNA expression of acyl CoA:diacylglycerol acyltransferase 2 (DGAT2), fatty acid binding protein-4 (FABP4), peroxisome proliferator-activated receptor protein γ (PPARγ), and leptin in males, which are key proteins involved in adipocyte hypertrophy; however no effect was observed in females. The last study assessed the effects of dose and duration of exposure to dietary n-3 PUFA on DHA accretion in the brain, and the expression of neurotrophins kn...

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Association among basal serum BDNF, cardiorespiratory fitness and cardiovascular disease risk factors in untrained healthy Korean men

Cited by 71 publications

References 44 publications

Physical activity and cognitive function in bariatric surgery candidates

Physical activity and cognitive function in bariatric surgery candidates

Brain derived neurotrophic factor (BDNF) in cardiometabolic physiology and diseases

Lipid metabolism and the risk factors of cardiovascular disease: implication of dietary omega-3 polyunsaturated fatty acids

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