Association among interleukin‐6 gene polymorphism, diabetes and periodontitis in a Chinese population

Xiao, Limin; Yan, Yuan; Xie, Chun; Wu, Fan; Xuan, Dongying; Wang, C. X.; Chen, L.; Sun, Shumei; Xie, Baoyi; Zhang, Jincai

doi:10.1111/j.1601-0825.2009.01584.x

Cited by 37 publications

(47 citation statements)

References 36 publications

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“…Most studies demonstrated that the IL-6 gene −572 G allele was associated with an increased risk of T2DM (Deng et al, 2004;Hamid et al, 2005;An et al, 2007;Koh et al, 2009;Tang et al, 2010;Wang et al, 2010). However, several other studies showed that there was no significant association between the IL-6 gene −572 C/G polymorphism and T2DM risk (Kitamura et al, 2002;Xiao et al, 2009;Zhang et al, 2011). A previous meta-analysis showed that the IL-6 gene -174 G/C polymorphism was not associated with T2DM risk (Qi et al, 2006).…”

Section: Discussionmentioning

confidence: 98%

“…Several epidemiological studies have reported the associations between several genetic variants of IL-6 and risk of T2DM, for instance, -174G/C, −572C/G, -597G/A and -1363G/T (Kitamura et al, 2002;Deng et al, 2004;Hamid et al, 2005;An et al, 2007;Chen et al, 2009;Koh et al, 2009;Xiao et al, 2009;Tang et al, 2010;Wang et al, 2010;Zhang et al, 2011). Of these studies, although the association between the IL-6 gene −572 C/G polymorphism and T2DM risk has been intensively studied, the results have been inconsistent.…”

Section: Discussionmentioning

confidence: 99%

“…Of these, 58 articles were excluded through reading the full text. Subsequently, 10 articles, with a total of 4335 T2MD cases and 7346 controls were included in the final meta-analysis (Kitamura et al, 2002;Deng et al, 2004;Hamid et al, 2005;An et al, 2007;Chen et al, 2009;Koh et al, 2009;Xiao et al, 2009;Tang et al, 2010;Wang et al, 2010;Zhang et al, 2011). From the 10 articles, nine focused on Asians, and one on Europeans.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Association between the Interleukin‐6 Gene −572 C/G Polymorphism and the Risk of Type 2 Diabetes Mellitus: A Meta‐Analysis of 11,681 Subjects

Yin

Sun²,

Zhang

et al. 2013

Annals of Human Genetics

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SummaryThe association between the interleukin-6 (IL-6) gene −572 C/G (rs1800796) polymorphism and type 2 diabetes mellitus (T2DM) risk remains controversial. Thus, we performed this meta-analysis by searching PubMed, Embase, Web of Science, CBMdisc and CNKI databases until January 30, 2012. In addition, hand searching of the references of identified articles was performed. A total of 10 case-control studies including 11,681 subjects were selected to evaluate the possible association. Our results showed evidence for significant association between the IL-6 gene −572 C/G polymorphism and T2DM risk (for G allele vs. C allele: odds ratio [OR] = 1.29, 95% confidence interval [CI] = 1.09-1.52, P = 0.002, P = 0.008 after Bonferroni testing; for G/G vs. C/C: OR = 1.89, 95% CI = 1.51-2.37, P < 0.00001, P < 0.00004 after Bonferroni testing; for GG vs. G/C + C/C: OR = 1.75, 95% CI = 1.20-2.56, P = 0.004, P = 0.016 after Bonferroni testing; for G/G + G/C vs. C/C: OR = 1.32, 95% CI = 1.11-1.57, P = 0.001, P = 0.004 after Bonferroni testing). In addition, similar results were obtained in the subgroup analysis based on ethnicity. In summary, the present meta-analysis suggests a significant association between the IL-6 gene −572 G allele and increased risk of T2DM.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Association between the Interleukin‐6 Gene −572 C/G Polymorphism and the Risk of Type 2 Diabetes Mellitus: A Meta‐Analysis of 11,681 Subjects

Yin

Sun²,

Zhang

et al. 2013

Annals of Human Genetics

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“…11 After that,several studies found different results regarding the relationship between IL-6(-174) gene polymorphism and periodontal disease. Some of these studies did not find any association between IL-6(-174) gene polymorphism and CP, 12,13,14,15 however some others found associations. 16,17 Studies investigating the relationship between IL-6(-174) gene polymorphism and AgP are limited.…”

Section: Introductionmentioning

confidence: 99%

IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parameters

et al. 2017

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“…2 CP affects the periodontium, and although bacteria are essential for the disease initiation, bacteria number and type are not sufficient to explain the differences in their severity. 3 Besides the pathogenesis of chronic lesions is associated with the interaction among biofilm, host response and influences of secondary factors, genetic polymorphism may be determinant of certain immunological aspects of the disease. 4 Smoking is an important epidemiological factor associated with CP 5 as well as some systemic conditions such as diabetes and cardiovascular disease, especially hypertension.…”

Section: Introductionmentioning

confidence: 99%

Polymorphic Genetic Markers in Patients with Chronic Periodontitis

Leão¹,

Barreto²,

Costa³

et al. 2016

Dent Open J

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CitationChronic periodontitis (CP) is an inflammatory disease caused by the interaction among dental plaque, periodontal tissues, and host immune responses, which causes bone resorption. Interleukin-6 (IL-6) and matrix metalloproteinase-1 (MMP-1) plays an important role in the periodontium destruction. Some authors have studied polymorphisms in these genes but the results were controversial. Objective: The aim of this study was to evaluate the association of polymorphisms in the promoter region of genes IL-6 (-174) and MMP-1 (-1607) with CP in a Northeastern Brazilian population. Methods: A case-control study of 64 cases of CP patients and 25 healthy subjects was performed. Genomic DNA was isolated from buccal mucosa and two single nucleotide polymorphism in IL-6 (-174 G/C) and MMP-1 (-1607 1G/2G) genes were analyzed using polymerase chain reaction followed by restriction fragment length polymorphism analysis (PCR-RFLP). Results: Regarding to results, there were no statistically significant differences between patients with CP and control group, nor to genotypes (p=0.734) nor to alleles (p=0.763), with respect to IL-6 polymorphism. For MMP-1 polymorphism, also we found no statistically significant difference in genotype (p=0.607) and allele (p=0.237) distribution between individuals with CP and the control group. Conclusion: We concluded that the polymorphism of the studied genes were not associated with susceptibility to CP in this Northeastern Brazilian population.

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Association among interleukin‐6 gene polymorphism, diabetes and periodontitis in a Chinese population

Abstract: The IL-6-572 genotype and allele distributions are unique to subjects with CP&T2DM in a Chinese population.

Cited by 37 publications

References 36 publications

Association between the Interleukin‐6 Gene −572 C/G Polymorphism and the Risk of Type 2 Diabetes Mellitus: A Meta‐Analysis of 11,681 Subjects

Association between the Interleukin‐6 Gene −572 C/G Polymorphism and the Risk of Type 2 Diabetes Mellitus: A Meta‐Analysis of 11,681 Subjects

IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parameters

Polymorphic Genetic Markers in Patients with Chronic Periodontitis

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