Association among Vitamin D, Oral Candidiasis, and Calprotectinemia in HIV

Sroussi, Hervé; Burke-Miller, Jane K.; French, Audrey L.; Adeyemi, Oluwatoyin; Weber, Kathleen M.; Lu, Yu; Cohen, Mardge H.

doi:10.1177/0022034512446342

Cited by 22 publications

(18 citation statements)

References 30 publications

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“…The other predisposing factors for candidiasis in this group included a decrement in the salivary concentration of the antimicrobial peptide calpronectin, the adverse effect of antiviral drugs and some specific sexual practices and habits. In the study by Sroussi et al (2012) a CD4 lymphocyte count \200 and vitamin D deficiency appeared to be the most crucial environmental factors leading to candidiasis in HIV-positive subjects.…”

Section: Periodontitismentioning

confidence: 91%

“…In an in vitro study Tang et al (2013) demonstrated that vitamin D reduced periodontitis related to Porphyromonas gingivalis by the inhibition of IL-8 expression in periodontal ligament cells. Sroussi et al (2012) showed that vitamin D deficiency in HIV-positive patients increased the risk of oral candidiasis. This opportunistic infection develops as a result of Arch.…”

Section: Periodontitismentioning

confidence: 99%

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Vitamin D and Its Relevance in the Etiopathogenesis of Oral Cavity Diseases

Ślebioda

Szponar

Dorocka‐Bobkowska

2016

Arch. Immunol. Ther. Exp.

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Vitamin D belongs to a group of fat-soluble secosteroids which assume many roles in the human organism. In humans the most important forms are vitamin D3 and vitamin D2. Their primary function is the regulation of the calcium and phosphorus balance, which promote the growth of healthy bony tissue. Studies over the past few years have revealed a much wider role of vitamin D involving the aging processes, carcinogenesis, the carbohydrate balance as well as the effects on the course of various infections. In this paper we discuss the basic functions of vitamin D in the human body and the mechanisms of its activity and we summarize recent reports on the impact of vitamin D on the oral cavity with a special emphasis on autoimmunologic diseases, including: recurrent aphthous stomatitis, Behçet syndrome and Sjögren syndrome.

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Section: Periodontitismentioning

confidence: 91%

Section: Periodontitismentioning

confidence: 99%

Vitamin D and Its Relevance in the Etiopathogenesis of Oral Cavity Diseases

Ślebioda

Szponar

Dorocka‐Bobkowska

2016

Arch. Immunol. Ther. Exp.

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“…Oral candidiasis occurs by the combination of host, fungal, and oral microenvironment-modifying factors. A relationship between vitamin D defi ciency and oral candidiasis has been observed in HIV-infected patients; however, this relationship was not dependent on the number of CD4 + T lymphocyte cells (13) .…”

mentioning

confidence: 96%

“…), is also linked to vitamin D defi ciency (13) . Oral candidiasis occurs by the combination of host, fungal, and oral microenvironment-modifying factors.…”

mentioning

confidence: 99%

“…Prosthetic stomatitis was the most (9.7%) frequently diagnosed lesion. Comparatively, the most common oral manifestation reported in HIV-infected patients and especially those with vitamin D defi ciency is oral candidiasis, given that vitamin D is an immunomodulator of T lymphocytes (13) . However, the association between cytology suggestive of Candida species infection and hypovitaminosis D was not signifi cant in this study (p = 0.369) (data not shown).…”

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confidence: 99%

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Prevalence of hypovitaminosis D and its association with oral lesions in HIV-infected Brazilian adults

Ferreira

Lima

Omena

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Introduction:This study assessed the prevalence of hypovitaminosis D and its association with oral candidiasis and clinical parameters of periodontitis (CPP) in HIV-infected patients. Methods: Periodontal examinations for the 113 HIV-infected patients were recorded using the Community Periodontal Index. A cytological smear from the lateral borders of the tongue was performed to evaluate candidiasis. Results: The frequency of hypovitaminosis D was 23.9%. In multivariate analysis, only the duration of exposure to HIV was associated with CPP .00)]. Conclusions: The prevalence of hypovitaminosis D was 23.9% and was not related with oral candidiasis or CPP.

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The interplay between vitamin D and viral infections

Teymoori‐Rad

Shokri

Salimi

et al. 2019

Reviews in Medical Virology

242

230

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Summary The pleiotropic role of vitamin D has been explored over the past decades and there is compelling evidence for an epidemiological association between poor vitamin D status and a variety of diseases. While the potential anti‐viral effect of vitamin D has recently been described, the underlying mechanisms by which vitamin D deficiency could contribute to viral disease development remain poorly understood. The possible interactions between viral infections and vitamin D appear to be more complex than previously thought. Recent findings indicate a complex interplay between viral infections and vitamin D, including the induction of anti‐viral state, functional immunoregulatory features, interaction with cellular and viral factors, induction of autophagy and apoptosis, and genetic and epigenetic alterations. While crosstalk between vitamin D and intracellular signalling pathways may provide an essential modulatory effect on viral gene transcription, the immunomodulatory effect of vitamin D on viral infections appears to be transient. The interplay between viral infections and vitamin D remains an intriguing concept, and the global imprint that vitamin D can have on the immune signature in the context of viral infections is an area of growing interest.

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Association among Vitamin D, Oral Candidiasis, and Calprotectinemia in HIV

Abstract: A supplemental appendix to this article is published electronically only at http://jdr.sagepub.com/supplemental.

Cited by 22 publications

References 30 publications

Vitamin D and Its Relevance in the Etiopathogenesis of Oral Cavity Diseases

Vitamin D and Its Relevance in the Etiopathogenesis of Oral Cavity Diseases

Prevalence of hypovitaminosis D and its association with oral lesions in HIV-infected Brazilian adults

The interplay between vitamin D and viral infections

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