Association analysis and molecular tagging of phytochemicals in the endangered medicinal plant licorice (Glycyrrhiza glabra L.)

Hosseini, Marjan; Ebrahimi, Mojtaba; Samsampour, Davood; Abadı́a, Javier; Khanahmadi, Morteza; Amirian, Rasool; Ghafoori, Iman Naseh; Ghaderi–Zefrehei, Mostafa; Gogorcena, Yolanda

doi:10.1016/j.phytochem.2020.112629

Cited by 14 publications

(3 citation statements)

References 62 publications

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“…Licorice is a versatile plant, and the content of active ingredients is an important indicator of the quality of the plant . Soil salinity affects the composition and content of secondary metabolites in licorice, and several bioactive constituents, such as triterpenoid saponins and flavonoids, show an increase in their levels in licorice root following salt stress . Exposure to low-salt stress promotes the accumulation of bioactive constituents in the long term, and key genes involved in the triterpenoid biosynthesis pathway are upregulated under NaCl stress .…”

Section: Introductionmentioning

confidence: 99%

Integrated Metabolomics and Transcriptomics Analyses Highlight the Flavonoid Compounds Response to Alkaline Salt Stress in Glycyrrhiza uralensis Leaves

Lv,

Zhu,

et al. 2024

J. Agric. Food Chem.

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Glycyrrhiza uralensis is a saline−alkali-tolerant plant whose aerial parts are rich in flavonoids; however, the role of these flavonoids in saline−alkali tolerance remains unclear. Herein, we performed physiological, metabolomics, and transcriptomics analyses in G. uralensis leaves under alkaline salt stress for different durations. Alkaline salt stress stimulated excessive accumulation of reactive oxygen species and consequently destroyed the cell membrane, causing cell death, and G. uralensis initiated osmotic regulation and the antioxidant system to respond to stress. In total, 803 metabolites, including 244 flavonoids, were detected via metabolomics analysis. Differentially altered metabolites and differentially expressed genes were coenriched in flavonoid-related pathways. Genes such as novel.4890, Glyur001511s00039602, and Glyur000775s00025737 were highly expressed, and flavonoid metabolites such as 2′-hydroxygenistein, apigenin, and 3-O-methylquercetin were upregulated. Thus, flavonoids as nonenzymatic antioxidants play an important role in stress tolerance. These findings provide novel insights into the response of G. uralensis to alkaline salt stress.

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Section: Introductionmentioning

confidence: 99%

Integrated Metabolomics and Transcriptomics Analyses Highlight the Flavonoid Compounds Response to Alkaline Salt Stress in Glycyrrhiza uralensis Leaves

Lv,

Zhu,

et al. 2024

J. Agric. Food Chem.

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“…Association analysis is an effective way to study the quantitative traits of plants and has been widely used in crops and other plants. With the continuous development of sequencing technology, a large number of molecular markers have been developed, and association analysis has been widely used in the discovery of genes related to various traits [16,17]. The association analysis method can be used to construct genetic maps and is a fast, low-cost method with a high mapping resolution.…”

Section: Introductionmentioning

confidence: 99%

Association Analysis of Tiller-Related Traits with EST-SSR Markers in Psathyrostachys juncea

Li,

Wang,

Yun

et al. 2023

Genes

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Psathyrostachys juncea is a long-lived perennial Gramineae grass with dense basal tillers and soft leaves. It is used widely in cold and dry areas of Eurasia and North America to establish grazing pasture and is even used as an ideal plant for revegetation and ecological restoration. Plant architecture, especially tillering traits, is critical for bunch grasses in breeding programs, and these traits in plants are mostly quantitative traits. In this study, the genetic diversity, population structure, and linkage disequilibrium of 480 individual lines were analyzed using 127 pairs of the EST-SSR marker, and a significant association between ten plant-architecture-related traits of P. juncea and molecular markers was found. The results of the genetic diversity analysis showed that the number of observed alleles was 1.957, the number of effective alleles was 1.682, Shannon’s information index was 0.554, observed heterozygosity was 0.353, expected heterozygosity was 0.379, and the polymorphism information content was 0.300. A total of 480 individual lines were clustered into five groups based on population genetic structure, principal coordinate analysis, and unweighted pair group method with arithmetic mean analysis (UPGMA). The linkage disequilibrium coefficient (r2) was between 0.00 and 0.68, with an average of 0.04, which indicated a relatively low level of linkage disequilibrium among loci. The results of the association analysis revealed 55 significant marker–trait associations (MTA). Moreover, nine SSR markers were associated with multiple traits. This study provides tools with promising applications in the molecular selection and breeding of P. juncea germplasm.

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“…This plant has been documented and reviewed as traditional remedy for the prevention of painful swellings, cough, colds, and influenza. ( Pastorino et al, 2018 ; Hosseini et al, 2020 ; Nasiri et al, 2020 ). G. glabra and its bioactive phytochemicals holds multiple pharmacological activities like, antidemulcent, expectorant, antiulcer, anti-inflammatory, anticancer and antidiabetic as an evidence from various review held in recent past ( Pandey et al, 2017 ; Sharma et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Revisiting liquorice (Glycyrrhiza glabra L.) as anti-inflammatory, antivirals and immunomodulators: Potential pharmacological applications with mechanistic insight.

et al. 2022

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Background Glycyrrhiza glabra L. ( G. glabra ) commonly known as liquorice is one of the highly exploited and utilized medicinal plant of the world. Since ancient times liquorice is considered as an auspicious and valuable traditional medicine across the world for treatment of various ailments. Method Several electronic online scientific databases such as Science Direct, PubMed, Scopus, Scifinder, Google Scholar, online books and reports were assessed for collecting information. All the collected information was classified into different sections to meet the objective of the paper. Results The electronic database search yielded 3908 articles from different countries. Out of them one ninety-eight articles published between 1956 and 2021 were included, corresponding to all detailed review on G. glabra and research on anti-inflammatories, antivirals and immunomodulatory through pre-clinical and clinical models. From all selective area of studies on G. glabra and its bioactive components it was established (including molecular mechanisms) as a suitable remedy as per the current requirement of pandemic situation arise through respiratory tract infection. Conclusion Different relevant studies have been thoroughly reviewed to gain an insight on utility of liquorice and its bioactive constituents for several pharmacological emphasizing anti-inflammatories, antivirals and immunomodulatory effects with special emphasized for prevention and treatment of COVID-19 infection with possible mechanism of action at molecular level. Proposed directions for future research are also outlined to encourage researchers to find out various mechanistic targets and useful value added products of liquorice in future investigations.

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Association analysis and molecular tagging of phytochemicals in the endangered medicinal plant licorice (Glycyrrhiza glabra L.)

Cited by 14 publications

References 62 publications

Integrated Metabolomics and Transcriptomics Analyses Highlight the Flavonoid Compounds Response to Alkaline Salt Stress in Glycyrrhiza uralensis Leaves

Integrated Metabolomics and Transcriptomics Analyses Highlight the Flavonoid Compounds Response to Alkaline Salt Stress in Glycyrrhiza uralensis Leaves

Association Analysis of Tiller-Related Traits with EST-SSR Markers in Psathyrostachys juncea

Revisiting liquorice (Glycyrrhiza glabra L.) as anti-inflammatory, antivirals and immunomodulators: Potential pharmacological applications with mechanistic insight.

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