2018
DOI: 10.1080/13816810.2018.1525752
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Association analysis of genetic polymorphisms and expression levels of selected genes involved in extracellular matrix turnover and angiogenesis with the risk of age-related macular degeneration

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Cited by 6 publications
(15 citation statements)
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“…Table 1 summarizes the polymorphisms of MMP genes that have been analyzed in AMD patients. Polymorphisms in MMP-1 (rs1799756) [30], MMP-3 (rs3025058) [26,32], and MMP-7 (rs11568818) [30,31] genes showed no statistical association with either the risk of AMD or disease progression.…”
Section: Matrix Metalloproteinases and Tissue Inhibitors Of Metalloprmentioning
confidence: 89%
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“…Table 1 summarizes the polymorphisms of MMP genes that have been analyzed in AMD patients. Polymorphisms in MMP-1 (rs1799756) [30], MMP-3 (rs3025058) [26,32], and MMP-7 (rs11568818) [30,31] genes showed no statistical association with either the risk of AMD or disease progression.…”
Section: Matrix Metalloproteinases and Tissue Inhibitors Of Metalloprmentioning
confidence: 89%
“…Fiotti et al [24] associated exudative AMD with longer microsatelites in the gene promoter region. The rs142450006, rs3918241, and rs3918242 MMP-9 polymorphisms were associated with an increased risk of AMD [27,28,31,32]. The rs142450006 MMP-9 polymorphism was also associated with progression to choroidal neovascularization [27,28].…”
Section: Matrix Metalloproteinases and Tissue Inhibitors Of Metalloprmentioning
confidence: 98%
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“…Using online search databases with keywords including "polymorphism", "age-related macular degeneration", and "meta-analysis", I summarized the findings from the latest published meta-analysis [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] as shown in Figure 1. Moreover, in this short communication additional meta-analysis of TNFα, CCL-2, MMP3, MMP7, MMP9, and TIMP2 were also included [19][20][21][22][23][24][25][26][27][28][29] . It was shown that a protective effect of TNFα -863A carrier (A vs C, OR = 0.67, P = 0.007; AA+CA vs CC, OR = 0.58, P = 0.001; CA vs AA+CC, OR = 0.55, P = 0.001; and CA vs CC, OR = 0.54, P = 0.001, Figure 2A-D) and TIMP2 -418C carrier (GC vs CC+GG, OR = 0.54, P = 0.018; and GC vs GG, OR = 0.56, P = 0.046, Figure 2E,F) to the development of AMD.…”
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confidence: 99%