Association analysis of two candidate polymorphisms in the Tumour Necrosis Factor-α gene with osteoarthritis in a Chinese population

Ji, Bin; Shi, Jixiang; Cheng, Xiuyan; Zhou, Junjie; Zhou, Quan; Cao, Chengfu; Pang, Jiangli

doi:10.1007/s00264-013-1931-4

Cited by 16 publications

(18 citation statements)

References 12 publications

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“…On the other hand, Sobhan et al [35] in a case-control study followed by a meta-analysis, demonstrated that this polymorphism in question may not be associated with susceptibility of OA, as other authors complement, ratifying the lack of relationship between the − 308 SNP TNF and OA [32,36]. In contrast, there are several studies with results agreeing with our data, where the presence of the A allele at position − 308 has a direct relation to the prevalence and severity of knee and hip OA [21,22,24,25,33,37], which is associated with a six-fold increase in transcriptional activity and higher levels of TNF-α protein [38,39]. In this same sense, Chen et al 2018 and Kou et al 2014 in metaanalyzes, with 983 and 257 cases of AO and 1355 and 305 controls, respectively, found an association between the − 308 G / A polymorphism of TNF in relation to the higher risk of OA.…”

Section: Discussionsupporting

confidence: 85%

“…Proinflammatory cytokines, such as TNF, are important mediators of this process by activating the production of metalloproteinases by chondrocytes, and stimulating the production of other proteins and cytokines, resulting in catabolic action and suppression of articular anabolism [16,31]. The polymorphisms of these cytokine genes are studied in understanding the complex etiology and pathophysiology of OA, representing a potential tool for identifying risk for the disease, which can be useful in preventive and clinical management [21,22,24,[27][28][29][30][32][33][34]. In this study we assessmnent the polymorphism − 308 G/A TNF with the presence and severity of OA in the elderly.…”

Section: Discussionmentioning

confidence: 99%

“…The TNF gene is located on 6p21, and a major polymorphisms involved in OA is the position -308 of the promoter region, with exchange of guanine for adenine (− 308 G/A; rs1800629). Several studies have shown that this polymorphism increase the genetic expression of this cytokine, related to higher prevalence of OA [18][19][20][21][22][23][24][25][26]. However, there is lack of information regarding a possible relationship between this genetic background and severity and functional status in elderly with OA.…”

Section: Introductionmentioning

confidence: 99%

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Functional status and severity of osteoarthritis in elderly is associated to the polymorphism of TNFA gene

Fernandes

Aníbal

et al. 2019

Adv Rheumatol

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Background: Osteoarthritis (OA) is a major musculoskeletal disease with high prevalence in the elderly. The study of genetic polymorphisms of inflammatory mediators involved in OA may contribute to the elucidation of the complex pathophysiology of this disease and identification of susceptibility individuals. Aim: This study aimed to evaluate the association between polymorphism at tumor necrosis factor alpha gene (SNP-308 G/A TNFA) with presence, severity and functional status of osteoarthritis in elderly. Methods: This study was characterized as case-control and encompassed 257 physically independent elderly (Mean Age: 68.55 ± 5.2; Minimum age: 60 and Maximum age: 82) were recruited. After this selection, the groups were divided in: 92 elderly individuals with osteoarthritis (case group) and 165 without the disease (control group). Methods: The individuals were genotyped by the TaqMan real-time PCR system. The subjects were classified based on the degree of radiological impairment according to the criteria of Kellgren-Laurence and regarding functional impairment using the WOMAC and LEQUESNE questionnaires. Results: TNFA gene polymorphic individuals (subjects harboring allele A) are more affected by OA (χ 2 = 8.7, p = 0.003), once they have major radiological lesion both in hip (Fisher-Freeman-Halton Test = 3.9, p = 0.04) and knee (Fisher-Freeman-Halton Test = 4.0, p = 0.04) as well as worse functional status assessed by the Lequesne questionnaire (Mann-Whitney, p = 0.04). At the multivariate analysis, after adjustment for age, gender, body mass index, the presence of rare allele for TNFA (allele A) increases the susceptibility to OA development [OR: 1.87 (95% CI: 1.1-3.2)]. Conclusion: We conclude that the SNP − 308 G/A of TNFA gene may affect osteoarthritis susceptibility, severity and functional status of individuals with osteoarthritis.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Functional status and severity of osteoarthritis in elderly is associated to the polymorphism of TNFA gene

Fernandes

Aníbal

et al. 2019

Adv Rheumatol

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“…Both studies included only knee OA (25,26). On the contrary, in the Han Chinese population, the TNF-α -308A allele was found to increase the risk, whereas the TNF-α -238 SNP did not play a role in OA patients (27). Similar findings were reported in the other Asian population, although the risk of OA was significantly higher for carriers of the TNF-α -308A allele in a Korean Population (28).…”

Section: Discussionmentioning

confidence: 55%

Association of cytokine gene polymorphisms with osteoarthritis susceptibility

et al. 2018

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Osteoarthritis (OA) is a multifactorial disease characterized by low-grade inflammatory processes that are mediated initially by the cells and factors of the innate immune system. In addition to their key role in inflammation, cytokines contribute to the pathogenesis of OA through angiogenesis and chemotaxis. The purpose of the present case-control study was to investigate a possible association of four cytokine single nucleotide polymorphisms (SNPs), IL-4R -3223C>T (rs2057768), IL-8 -251T>A (rs4073), IL-10 -1082A>G (rs1800896) and TNF -A-308G>A (rs1800629) with OA susceptibility. Genomic DNA was isolated from blood samples collected from 305 Romanian subjects (90 patients with OA and 215 controls) and the genotyping of the SNPs was performed by TaqMan allelic discrimination polymerase chain reaction using predesigned assays. Our data indicated a significant association for IL-4R rs2057768 C>T SNP. The subjects that carried the CT genotype were at a higher risk for OA (OR 2.03, 95% CI: 1.21-3.42, P=0.007) compared with those that had the CC genotype. Furthermore, the carriers of the T allele were at a 1.9 fold higher risk for OA (OR 1.92; 95% CI, 1.17-3.17; P=0.009) in a dominant model. The association remained significant only for knee OA in the subgroups analysis. No correlations were observed between the other remaining SNPs and OA. The results suggested that the IL-4R rs2057768 SNP could contribute to OA susceptibility in the Romanian population, providing novel evidence for the involvement of IL-4/IL-4R pair in the pathogenesis of OA.

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“…The application of traditional Chinese medicine for treating the malignant tumors has a long history in China, but traditional Chinese medicine has failed to be recognized in the medical field due to the complexity of Chinese herbal medicinal ingredients and unclear antitumor mechanism. Thus, there are several restrictions in conducting clinical trials for traditional Chinese remedies (5,6). In recent years, several studies have been conducted on the adverse side effects associated with semi-synthetic and synthetic chemotherapy drugs used for treatment of tumors.…”

Section: Introductionmentioning

confidence: 99%

Anti-tumoral activity of native compound morelloflavone in glioma

Li¹,

Ai²,

Sun³

et al. 2016

Oncology Letters

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The aim of the study was to investigate the anti-tumoral activity of morelloflavone substances with different structures. We also studied the possible link between morelloflavone structure and its function. Various types of chromatographic techniques were used to isolate and screen morelloflavone substances from the extracts of gambogic tree trunk and the morelloflavone structures were identified by analytical techniques such as high resolution mass spectrometry and nuclear magnetism. Anti-tumoral activities of different compounds were investigated and the link between the antitumor activity and the structure of compound was exaimed. Our results showed that the isolated morelloflavone substances demonstrated a certain level of antitumor activity. The compound no. 1 had the strongest effect to inhibit glioma U87 and C6 cells followed by compound no. 2 while compound no. 5 was the weakest among them. We conducted a preliminary analysis on the structure-function relationship through the structure comparison and we concluded that the antitumor effects of morelloflavone substances with different structures were significantly different from each other. Thus, the glucose chain in C4 position of biflavone structure can enhance the antitumor activity of the compound in glioma cells. Additionally, the formation of intramolecular hydrogen bonds in biflavone compounds may also play a role in enhancing the antitumor activity and inhibition rate.

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Association analysis of two candidate polymorphisms in the Tumour Necrosis Factor-α gene with osteoarthritis in a Chinese population

Cited by 16 publications

References 12 publications

Functional status and severity of osteoarthritis in elderly is associated to the polymorphism of TNFA gene

Functional status and severity of osteoarthritis in elderly is associated to the polymorphism of TNFA gene

Association of cytokine gene polymorphisms with osteoarthritis susceptibility

Anti-tumoral activity of native compound morelloflavone in glioma

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