Association between -174G&gt;C polymorphism in the IL-6 promoter region and the risk of obesity

Hu, Man; Yu, Zhaomin; Luo, Dan; Zhang, Haiming; Li, Jinxiao; Liang, Fanrong; Chen, Rui

doi:10.1097/md.0000000000011773

Cited by 24 publications

(12 citation statements)

References 34 publications

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“…Intronic rs1800795 has proven to be in moderate LD with a common variant: rs2069845 [110]. Findings about the latter SNP are inconsistent [111,112,185]. Intron variant rs1800796 C is associated with greater waist circumference in Mexican-Americans [113].…”

Section: Interleukins and Their Receptorsmentioning

confidence: 99%

Innate-Immunity Genes in Obesity

Михайлова

Ivanoshchuk

2021

JPM

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The main functions of adipose tissue are thought to be storage and mobilization of the body’s energy reserves, active and passive thermoregulation, participation in the spatial organization of internal organs, protection of the body from lipotoxicity, and ectopic lipid deposition. After the discovery of adipokines, the endocrine function was added to the above list, and after the identification of crosstalk between adipocytes and immune cells, an immune function was suggested. Nonetheless, it turned out that the mechanisms underlying mutual regulatory relations of adipocytes, preadipocytes, immune cells, and their microenvironment are complex and redundant at many levels. One possible way to elucidate the picture of adipose-tissue regulation is to determine genetic variants correlating with obesity. In this review, we examine various aspects of adipose-tissue involvement in innate immune responses as well as variants of immune-response genes associated with obesity.

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Section: Interleukins and Their Receptorsmentioning

confidence: 99%

Innate-Immunity Genes in Obesity

Михайлова

Ivanoshchuk

2021

JPM

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“…Furthermore, IL-6 regulates/stimulates production of cell adhesion molecules, acute phase protein, and mediates the release of other cytokines that amplify the inflammatory response which influence the function of adipose tissue (9) . The human IL-6 gene is located on chromosome 7p21, and the -174G/C polymorphism consists of a single nucleotide change from G to C at position -174 in the promoter region (10) . The association of the IL-6-174G/C polymorphism with obesity risk has been evaluated in several genetic studies.…”

Section: Introductionmentioning

confidence: 99%

Interleukin-6 (174G/C) Gene Polymorphism and Serum Levels of IL-6, their Association with Risk of Obesity in Iraqi Childhood Populations

2020

MLU

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Background: Childhood obesity is one of the most serious public health challenges of the 21st century. Aim:The present study was conducted to investigate the association of CD14 genotype and serum levels of IL-6 with risk of ischemic stroke.Method : A total of 60 patients with obesity were included in the study who were admitted to hospital from the period between March to August 2020, and other groups consist of 60 apparently healthy individuals. A five ml of blood samples were collected, 3 ml of each sample for polymerase chain reaction amplification and detection of IL-6 technique. The remaining (2 ml) for IL-6 serum levels by ELISA assay procedure.Results: IL-6 (-174G/C) genotype was significantly associated with increased risk of obesity (P = 0.004). However, IL-6 serum levels were higher in subjects with GG genotype compared with those with CG or CC genotype (P < 0.001). Conclusion:A significant correlation between IL-6 genotype and IL-6 levels were higher level in subjects with GG genotype compared with those with CG or CC genotype.

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“…Although the pathogenesis of obesity is complex, recent evidence suggests that genetic variants, especially functional single nucleotide polymorphisms (SNPs) in genes contribute to interindividual variability in susceptibility to obesity [7–9]. Vitamin D receptor (VDR) is a gene that encodes a nuclear receptor to mediate the inhibitory effects of vitamin D3 on adipogenesis [10,11].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Receptor Polymorphisms Associated with Susceptibility to Obesity: A Meta-Analysis

Chen

Wang

et al. 2019

Med Sci Monit

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BackgroundObesity has become a global public health problem. Obesity increases the risk of several lethal diseases. This study aimed to assess whether the obesity susceptibility was associated with genetic variation in vitamin D receptor (VDR) gene by conducting a meta-analysis.Material/MethodsPubMed, EMBASE and Cochrane Library databases were screened for all relevant articles published up to October 2018. The pooled odds ratios (OR) were calculated using STATA 13.0 software for 4 polymorphisms in the VDR gene (ApaI, BsmI, FokI and TaqI).ResultsSeven case-control studies, including 1188 obese patients and 1657 healthy controls, were recruited. The pooled findings showed that there were no associations between obesity risk and the VDR polymorphisms in ApaI, BsmI and TaqI loci overall. However, VDR TaqI polymorphism was associated with the risk of obesity in Asian under homozygous [TT versus tt: odds ratio (OR)=0.26, 95% confidence interval (CI)=0.14–0.49; P<0.001], heterozygous (Tt versus tt: OR=0.34, 95% CI=0.18–0.64; P=0.001), and dominant (TT+Tt versus tt: OR=0.30, 95% CI=0.17–0.52; P<0.001) models; FokI variant was related with increased risk of obesity only under dominant model (FF+Ff versus ff: OR=1.54, 95% CI=1.15–2.06; P=0.004).ConclusionsOur meta-analysis results suggest that the T allele of TaqI may have a protective effect, while the F allele of FokI is proposed as a risk factor related to obesity.

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Association between -174G>C polymorphism in the IL-6 promoter region and the risk of obesity

Cited by 24 publications

References 34 publications

Innate-Immunity Genes in Obesity

Innate-Immunity Genes in Obesity

Interleukin-6 (174G/C) Gene Polymorphism and Serum Levels of IL-6, their Association with Risk of Obesity in Iraqi Childhood Populations

Vitamin D Receptor Polymorphisms Associated with Susceptibility to Obesity: A Meta-Analysis

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