Association Between 2-Hz Electroacupuncture Stimulation Near the Cervical Sympathetic Trunk and Nasal Skin Temperature: A Randomized Crossover Study

Takahashi, Kazufumi; Imai, Kenji

doi:10.1089/acu.2020.1517

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…Somatic stimulation exerted a neuromodulation action on sympathetic activity in a somatotopy‐, intensity‐ and frequency‐dependent manners (Cui et al, 2020; Kim et al, 2007; Liu et al, 2020; Takahashi & Imai, 2021). Sato et al systematically studied the effects of different intensities of somatic stimulation on adrenal sympathetic activity and catecholamine concentration in the peripheral blood of rats.…”

Section: Discussionmentioning

confidence: 99%

Adrenal sympathetic nerve mediated the anti‐inflammatory effect of electroacupuncture at ST25 acupoint in a rat model of sepsis

Zhang

Cui

Liu

et al. 2022

The Anatomical Record

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Acupuncture plays a vital anti‐inflammatory action in sepsis by activating autonomic nerve anti‐inflammatory pathways, such as sympathoadrenal medullary pathway, but the mechanism remains unclear. This study aims to explore the optimum parameter of electroacupuncture (EA) stimulation in regulating the sympathoadrenal medullary pathway and evaluate EA's anti‐inflammatory effect on sepsis. To determine the optimum parameter of EA at homotopic acupoint on adrenal sympathetic activity, the left adrenal sympathetic nerve firing rate evoked by different intensities of single shock electrical stimulation (ES) at ST25 in healthy male Sprague–Dawley rats were evaluated by in vivo electrophysiological recording, and the levels of norepinephrine (NE) and its metabolites normetanephrine (NMN) were also examined using mass spectrometry. To verify the role of EA at ST25 in sepsis, the rats were given an intraperitoneal injection of lipopolysaccharide (LPS) to induce sepsis model, and survival rate, clinical score, and the level of interleukin (IL)‐6, IL‐1β, and IL‐10 were evaluated after EA application. We observed that 3 mA is the optimal intensity for activating adrenal sympathetic nerve, which significantly elevated the level of NE in the peripheral blood. For LPS‐treated rats, EA at the ST25 apparently increased the survival rate and improved the clinical score compared to the control group. Furthermore, 3 mA EA at ST25 significantly decreased pro‐inflammatory cytokines IL‐6 and IL‐1β and upregulated anti‐inflammatory cytokine IL‐10 compared to the LPS‐treated group. Overall, our data suggested that 3 mA is the optimal EA intensity at ST25 to activate the sympathoadrenal medullary pathway and exert an anti‐inflammatory effect in sepsis.

show abstract

Section: Discussionmentioning

confidence: 99%

Adrenal sympathetic nerve mediated the anti‐inflammatory effect of electroacupuncture at ST25 acupoint in a rat model of sepsis

Zhang

Cui

Liu

et al. 2022

The Anatomical Record

View full text Add to dashboard Cite

show abstract

“…Gao et al, 2015), located at the same dermatome as the adrenal medulla, exhibited a better action in upregulating adrenal medulla hormones releasing via activating the adrenal sympathetic nerve (Fig1, 2). Accumulating studies suggested that somatic stimulation exerted a neuromodulation action on sympathetic activity in a somatotopy-, intensity-and frequency-dependent manners (Cui et al, 2020;Kim et al, 2007;Liu et al, 2020;Takahashi & Imai, 2021). Sato et al systematically studied the effects of different intensities of somatic stimulation on adrenal sympathetic activity and catecholamine concentration in the peripheral blood of rats.…”

Section: Discussionmentioning

confidence: 99%

Adrenal sympathetic nerve mediated the anti-inflammatory effect of electroacupuncture at ST25 acupoint on a rat model of sepsis

Zhang

Cui

Liu

et al. 2022

Preprint

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Acupuncture plays a vital anti-inflammatory action on sepsis through activating autonomic nerve anti-inflammatory pathways, such as sympathoadrenal medullary pathway, but the mechanism remains unclear. This study aims to explore the optimum parameter of electroacupuncture (EA) stimulation in regulating sympathoadrenal medullary pathway and evaluate EA anti-inflammatory effect on sepsis. To explore the optimum parameter of EA at homosegmental acupoint on adrenal sympathetic activity, the left adrenal sympathetic nerve firing rate evoked by different intensities of single shock electrical stimulation (ES) at ST25 in healthy male Sprague-Dawley (SD) rats were evaluated by in vivo electrophysiological recording, and the levels of norepinephrine (NE) and its metabolites were also examined using mass spectrometry. To verify the role of EA at ST25 in sepsis, the rat was given intraperitoneal injection lipopolysaccharide to induce sepsis model, and survival rate, clinical score, and the level of interleukin (IL)-6, IL-1β, and IL-10 were evaluated after EA application. We observed that 3 mA is the optimal intensity on activating adrenal sympathetic nerve, which significantly elevated the level of NE in the peripheral blood. For LPS-treated rats, EA at the ST25 apparently increased the survival rate and improved the clinical score compared to the control group. Furthermore, 3 mA EA at ST25 significantly decreased pro-inflammatory cytokines IL-6 and IL-1β and upregulated anti-inflammatory cytokine IL-10 compared to the Lipopolysaccharide (LPS)-treated group. Overall, these data suggest that 3 mA is the optimal EA intensity at ST25 to activate the sympathoadrenal medullary pathway and exert an anti-inflammatory effect on sepsis.

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Effects of Acupuncture Stimulation to Cervical Sympathetic Trunk on Maximal Respiratory Mouth Pressure: A Randomized Crossover Study

Takahashi

Imai

2022

Medical Acupuncture

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Association Between 2-Hz Electroacupuncture Stimulation Near the Cervical Sympathetic Trunk and Nasal Skin Temperature: A Randomized Crossover Study

Cited by 4 publications

References 13 publications

Adrenal sympathetic nerve mediated the anti‐inflammatory effect of electroacupuncture at ST25 acupoint in a rat model of sepsis

Adrenal sympathetic nerve mediated the anti‐inflammatory effect of electroacupuncture at ST25 acupoint in a rat model of sepsis

Adrenal sympathetic nerve mediated the anti-inflammatory effect of electroacupuncture at ST25 acupoint on a rat model of sepsis

Effects of Acupuncture Stimulation to Cervical Sympathetic Trunk on Maximal Respiratory Mouth Pressure: A Randomized Crossover Study

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