Association between 5‐hydroxytryptamine gene polymorphism rs140700 and primary insomnia in Chinese population

Abstract

Background: Primary insomnia is a worldwide problem and it has a considerable negative impact on one's physical and mental health. Studies have shown that nonsynonymous Single-nucleotide polymorphisms in 5-hydroxytryptamine (serotonin or 5-HT) are related to primary insomnia. Previous studies have shown that 5-HT polymorphism (rs140700) is related to depression, and insomnia is often accompanied by depression and anxiety. The relationship between this site and primary insomnia is unknown. We speculated that this site may be related to primary insomnia, so we investigated the relationship between rs140700 and primary insomnia.Aims: To explore the relationship between the 5-HT gene polymorphism rs140700 and primary insomnia.Methods: In this study, we included 57 patients with primary insomnia and 54 ageand gender-matched normal controls. The subjects who belonged to the Chinese population were subjected to polysomnography for three consecutive nights. Their sleep quality was assessed, and the genotypes of the 5-hydroxytryptamine (5-HT) gene polymorphism rs140700 were determined by the flight mass spectrometry. Results:The genotype distributions of the 5-HT gene polymorphism rs140700 were in Hardy-Weinberg equilibrium in both patients and controls (P > 0.05). The allele and genotype distributions of this variant were comparable between the patients and controls in all subjects and between genders (all P > 0.05). The influence of rs140700 on percentage of stage 1 (P = 0.015) change and arousal index (P = 0.028) of primary insomnia was statistically significant. The logistic multi-factor regression analysis results revealed that 5-HT gene polymorphism rs140700 was not a risk factor for primary insomnia in the Chinese population (P = 0.589). Conclusions:The 5-HT gene polymorphism rs140700 may not be a susceptibility locus for primary insomnia in the Chinese population. †These authors contributed equally to this study.

Effect of acupuncture combined with Ningshen mixture on climacteric insomnia: A randomized controlled trial

“…5-TH and β-EP are monoamine neurotransmitters, which are related to behavior and emotion, and participate in the regulation of sleep-wake cycle, so changes in their levels can truly reflect the quality of sleep. [21] In this study, the level of 5-TH and β-EP were obviously increased in study group after treatment. On the one hand, it can benefit from the regulating effect of Dan-shen in Ningshen mixture on neurotransmitters; On the other hand, it may be beneficial that acupuncture can regulate the activity and content of neurotransmitters by regulating the function of the neuroendocrine system.…”

Potential genetic and epigenetic mechanisms in insomnia: A systematic review

“…In this framework, the 5‐HTTLPR S‐allele was found to predispose to risk of stress‐related insomnia (Huang et al, 2021) and depression‐related insomnia (Polito et al, 2015), as well as insomnia (Deuschle et al, 2010; Huang et al, 2021; Pallesen et al, 2019), although other findings do not confirm an involvement of the 5‐HTTLPR allele or of other genes involved in the biosynthesis of 5‐HT in insomnia (Hui et al, 2021; Mei et al, 2018; van Dalfsen & Markus, 2019).…”

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“…5-HT, recognized as the “pleasure neurotransmitter”, exerts its functions within the brain through its extensive family of receptors. Notably, the 5-HT1 subfamily has emerged as a crucial target for therapeutic medications aimed at addressing psychiatric disorders [ 9 , 10 , 11 ]. GABA serves as a critical inhibitory neurotransmitter within the central nervous system (CNS), with the GABA A-type receptor (GABAAR) being mainly associated with insomnia symptoms [ 12 , 13 , 14 ].…”