Association between 8q24 rs6983267 polymorphism and cancer susceptibility: a meta-analysis involving 170,737 subjects

Zhu, Man; Xue, Wei; Liu, Xuefang; Wang, Yingchao; Liang, Chunzi; Tu, Jiancheng

doi:10.18632/oncotarget.18960

Cited by 14 publications

(13 citation statements)

References 97 publications

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“…This association between 8q24 and risk for thyroid cancer and other cancers (prostate cancer, colorectal cancer, breast cancer, etc. ), has been confirmed in recent studies [ 105 , 106 ].…”

Section: Non-syndromic Familial Non-medullary Thyroid Carcinoma (Nsfnsupporting

confidence: 70%

Inherited Follicular Epithelial-Derived Thyroid Carcinomas: From Molecular Biology to Histological Correlates

et al. 2021

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Cancer derived from thyroid follicular epithelial cells is common; it represents the most common endocrine malignancy. The molecular features of sporadic tumors have been clarified in the past decade. However the incidence of familial disease has not been emphasized and is often overlooked in routine practice. A careful clinical documentation of family history or familial syndromes that can be associated with thyroid disease can help identify germline susceptibility-driven thyroid neoplasia. In this review, we summarize a large body of information about both syndromic and non-syndromic familial thyroid carcinomas. A significant number of patients with inherited non-medullary thyroid carcinomas manifest disease that appears to be sporadic disease even in some syndromic cases. The cytomorphology of the tumor(s), molecular immunohistochemistry, the findings in the non-tumorous thyroid parenchyma and other associated lesions may provide insight into the underlying syndromic disorder. However, the increasing evidence of familial predisposition to non-syndromic thyroid cancers is raising questions about the importance of genetics and epigenetics. What appears to be “sporadic” is becoming less often truly so and more often an opportunity to identify and understand novel genetic variants that underlie tumorigenesis. Pathologists must be aware of the unusual morphologic features that should prompt germline screening. Therefore, recognition of harbingers of specific germline susceptibility syndromes can assist in providing information to facilitate early detection to prevent aggressive disease.

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“…This association between 8q24 and risk for thyroid cancer and other cancers (prostate cancer, colorectal cancer, breast cancer, etc. ), has been confirmed in recent studies [ 105 , 106 ].…”

Section: Non-syndromic Familial Non-medullary Thyroid Carcinoma (Nsfnsupporting

confidence: 70%

Inherited Follicular Epithelial-Derived Thyroid Carcinomas: From Molecular Biology to Histological Correlates

et al. 2021

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“…Numerical abnormalities of CTCs can be divided into different subtypes, such as triploidy, tetroploidy and multiploidy. Previous studies have shown that CEP 8 reflects numerical chromosomal abnormalities, which have been reported in thyroid cancer, and lung, esophageal, gastric and colon cancers [27][28][29]. Thus, aneuploidy of CEP 8 examined by CEP8-iFISH can be used to detect CTCs.…”

Section: Discussionmentioning

confidence: 94%

Circulating Tumor Cells Correlate with Clinicopathological Features and Outcomes in Differentiated Thyroid Cancer

Qiu¹,

Wei²,

Sun³

et al. 2018

Cell Physiol Biochem

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Background/Aims: As biomarkers, circulating tumor cells (CTCs) from solid tumors can predict metastases and prognoses, and help monitor treatment efficacy. However, conventional CellSearch methods have low sensitivity to differentiated thyroid cancer (DTC) CTCs. In this study, for the first time, we used negative enriching (NE) immunofluorescence–in situ hybridization (iFISH) of chromosome 8 to capture and identify CTCs in DTC patients; and investigated how CTCs correlate with clinicopathological factors and prognosis in DTC patients with distant metastases (DM). Methods: In this prospective study, we enrolled 72 patients with DTC before they underwent ¹³¹I treatment, and 30 healthy controls (HC). Their CTCs were measured in 7.5 ml peripheral blood using the NE–iFISH technique. CTC was defined by the aneuploidy. Results: We detected CTCs in 62 (86.1%) of the 72 subjects with DTC. The mean number of CTCs in patients with DTC with DM (DM⁺) was significantly higher than in the HC group (P< 0.001) and DTC patients without DM (DM^-; P=0.0016). We found CTCs ≥ 5 was significantly associated with DM⁺ DTC (P=0.009; sensitivity: 64.3%; specificity: 83.8%); CTCs ≥ 7 was related to poor response to ¹³¹I treatment (sensitivity: 73.7 %; specificity: 69.6 %), and was also associated with worse prognosis in DM⁺ DTC (P< 0.001). Conclusion: We found CTCs ≥ 5 to be a potential predictive index for DM⁺ DTC; and CTCs ≥7 as a possible indicator of poor response to ¹³¹I treatment and worse prognosis in DM⁺ DTC.

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“…In recent years, an increasing number of studies have confirmed that lncRNA CCAT2 SNPs are associated with susceptibility to multiple diseases. For example, rs6983267 polymorphisms are associated with significantly increased risk for prostate cancer in Asians (Zhu et al, ) and increased the susceptibility of ovarian cancer in Han Chinese women (Han et al, ). However, some other studies have revealed that rs6983267 showed a negligible association with breast cancer risk (Y. Zhang et al, ), and He et al () did not find a significant association between rs6983267 polymorphism and gastric cancer risk in a Chinese population.…”

Section: Discussionmentioning

confidence: 99%

The lncRNA CCAT2 rs6983267 G allele is associated with decreased susceptibility to recurrent miscarriage

Che

Huang²,

Fang³

et al. 2019

Journal Cellular Physiology

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Genetics might play various roles in susceptibility to recurrent miscarriage, and previous studies suggest that some gene polymorphisms might be associated with abortion and breast cancer onset. Colon cancer-associated transcript 2 (CCAT2) is a novel long noncoding RNA (lncRNA) transcript that might be correlated with susceptibility to multiple cancers, including breast cancer.However, whether lncRNA CCAT2 polymorphisms are related to susceptibility to recurrent miscarriage is unclear. We genotyped two lncRNA CCAT2 polymorphisms (rs6983267 and rs3843549) in 248 patients with recurrent miscarriage and 392 controls through a TaqMan real-time polymerase chain reaction assay, and the strength of each association was evaluated via 95% confidence intervals (CIs) and odds ratios (ORs). Our results showed that the rs6983267 G allele in lncRNA CCAT2 was associated with decreased susceptibility to recurrent miscarriage (TG vs. TT: adjusted OR = 0.603; 95% CI = 0.420-0.866; p = 0.0062; GG/TG vs. TT: adjusted OR = 0.620; 95% CI = 0.441-0.873; p = 0.0061). The combined analysis of the two protective polymorphisms (rs3843549 AA and rs6983267 TG/GG) revealed that individuals with two unfavorable alleles exhibited a lower risk of recurrent miscarriage than those with no or only one unfavorable allele (adjusted OR = 0.531; 95% CI = 0.382-0.739). Moreover, the decreased risk associated with the two protective alleles was most obvious in women aged less than 35 years (OR = 0.551; 95% CI = 0.378-0.8803; p = 0.0019) and in women with two to three miscarriages (adjusted OR = 0.466; 95% CI = 0.318-0.683; p < 0.0001). In conclusion, our study indicates that the rs6983267G allele might contribute to a decreased risk of recurrent miscarriage in the South Chinese population.

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Association between 8q24 rs6983267 polymorphism and cancer susceptibility: a meta-analysis involving 170,737 subjects

Cited by 14 publications

References 97 publications

Inherited Follicular Epithelial-Derived Thyroid Carcinomas: From Molecular Biology to Histological Correlates

Inherited Follicular Epithelial-Derived Thyroid Carcinomas: From Molecular Biology to Histological Correlates

Circulating Tumor Cells Correlate with Clinicopathological Features and Outcomes in Differentiated Thyroid Cancer

The lncRNA CCAT2 rs6983267 G allele is associated with decreased susceptibility to recurrent miscarriage

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