Association Between ABCA1 (R219K) Polymorphism and Lipid Profiles: A Meta-Analysis

Abstract

Background Conflicting evidence was found about the relationship between lipid profiles and R219K in adenosine triphosphate-binding cassette exporter A1 (ABCA1) gene. A meta-analysis was conducted to assess the effect of R219K on lipid level. Methods Multi-database literature search was performed in accordance with PRISMA guidelines. The effect of each study was expressed by standard mean difference (SMD) and 95% confidence interval and pooled by meta-analysis in a random-effects model. Sub-group and meta-regression analyses were also conducted to explore potential heterogeneity sources. Results Overall pooled effect showed that individuals with RR genotype had significantly lower HDLC level (SMD = -0.17 mmol/L, 95% CI: -0.22 ~ -0.12, z = -6.39, P < 0.001) than those with K allele. However, this effect mainly presented in Asians (SMD = -0.24 mmol/L, 95% CI: -0.32 ~ -0.17, z = 6.60, P < 0.001) rather than Caucasian populations, and the difference was significant (Q = 5.20, df = 1, P = 0.02). The relationship between R219K polymorphism and LDLC, TC, and TG levels was not determined. Conclusions R219K polymorphism in the ABCA1 gene was associated with HDLC level in Asian populations in the present meta-analysis. This correlation was not substantially affected by the age, gender or health condition of individuals.

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“…The K allele, which is associated with slower PD progression, also affects the lipid profile of those who carry the genotype. Compared to individuals carrying ABCA1 R219K RR or RK, ABCA1 R219K K genotype carriers have elevated high-density lipoprotein cholesterol and lower triglyceride levels [ 50 ]. It remains to be determined whether the differences in lipid profiles are responsible for clinical differences between these groups.…”