Association between abnormal glycolipid level and cognitive dysfunction in drug-naïve patients with bipolar disorder

Qiu, Yan; Li, Sujuan; Teng, Ziwei; Tan, Yuxi; Xu, Xuelei; Yang, Min; Zhao, Ziru; Liu, Jieyu; Tang, Hui; Xiang, Hui; Chen, Jindong; Wang, Bolun; Wu, Haishan

doi:10.1016/j.jad.2021.10.100

Cited by 12 publications

(13 citation statements)

References 51 publications

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“…It was suggested to promote cell apoptosis and repress glycolipid metabolism pathway through inhibiting the expression of hexokinase 2 and ATP citrate lyase, the key enzymes related to glycolipid metabolism ( Dong et al, 2021 ). Given that the abnormal glycolipid metabolism was associated with cognitive dysfunction ( Arend et al, 2018 ; Qiu et al, 2022 ), the changes in the expression of mm9_circ_009789, mm9_circ_004229, Prkcb and Zbtb4 in our POCD model suggests that the PKC signaling pathway, neural cell apoptosis and glycolipid metabolism pathway may be regulated by mm9_circ_009789 and mm9_circ_004229-associated-ceRNA networks and involved in age-related POCD neuropathogenesis. Another target of mmu-miR-298-5P, Syngap1, was downregulated instead of upregulated in our POCD model, which may because it was powerfully affected by other ways of gene expression regulation rather than mmu-miR-298-5P.…”

Section: Discussionmentioning

confidence: 97%

Characterization of circRNA-Associated-ceRNA Networks Involved in the Pathogenesis of Postoperative Cognitive Dysfunction in Aging Mice

Zhang

Lin

Yang

et al. 2022

Front. Aging Neurosci.

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Postoperative cognitive dysfunction (POCD) is a clinical entity associated with declined cognitive function following surgery. It occurs more frequently in elderly patients. Recent studies have shown that circRNA-associated-ceRNA networks, constructed based on interactions between circRNA-miRNA and miRNA-mRNA, provide key insight into the molecular mechanisms underlying the pathogenesis of several neurological diseases. However, the mechanism of POCD remains undetermined. In this study, laparotomies were performed under isoflurane anesthesia on young (2-month-old) and aging (17-month-old) male C57BL/6 mice. The results showed that the aging mice were more likely than the young mice to develop POCD. Subsequently, differentially expressed circRNAs, miRNAs, and mRNAs were characterized by RNA sequencing the hippocampi of young and aging mice under control and surgery conditions. Six circRNAs, 6 miRNAs, and 203 mRNAs were identified to construct the circRNA-associated-ceRNA network for the control condition, while 13 circRNAs, 8 miRNAs, and 189 mRNAs were used for the circRNA-associated-ceRNA network for the surgery condition. Further Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of these two networks revealed that the circRNA-associated-ceRNA networks are involved in POCD pathogenesis though modulating the Wnt and VEGF signaling pathways, as well as neural processes associated with long-term synaptic depression and synaptic transmission. In particular, the mmu-miR-298-5P regulatory pathway identified in this study’s mouse model suggests that mm9_circ_009789- and mm9_circ_004229-associated-ceRNA networks as closely related to the occurrence of POCD through regulating PKC signaling pathway, neural cell apoptosis and glycolipid metabolism pathway. These findings provide possible insight into the role of the circRNA-associated-ceRNA networks, helping to unravel the complexity of the molecular pathogenesis of POCD.

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Section: Discussionmentioning

confidence: 97%

Characterization of circRNA-Associated-ceRNA Networks Involved in the Pathogenesis of Postoperative Cognitive Dysfunction in Aging Mice

Zhang

Lin

Yang

et al. 2022

Front. Aging Neurosci.

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“…We found that triglycerides and LDL cholesterol were associated with increased obesity in BD, consistent with previous studies showing an association between obesity and blood lipid-related parameters in the general population ( 46 ). Triglycerides were much higher in drug-naïve BD patients and BD patients taking medications than in healthy controls, and triglycerides were found to be associated with cognitive dysfunction and worse cognitive flexibility in BD ( 47 ). Triglycerides were the most accurate factor to identify individuals with greater cognitive impairment from among patients with severe mental disorders ( 48 ).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and associated factors of obesity and overweight in Chinese patients with bipolar disorder

et al. 2022

Front. Psychiatry

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ObjectDespite abundant literature demonstrating a high prevalence of obesity and overweight in people with bipolar disorder (BD), little is known about this topic in China. Therefore, we assessed the prevalence and associated factors of obesity and overweight among inpatients with BD in our hospital, one of the largest public psychiatric hospitals in China.MethodsIn this retrospective, cross-sectional study, 1,169 inpatients ≥18 years with BD during 2019 were included. Obesity was defined as having a BMI ≥25 kg/m2, and overweight was defined as having a BMI from 23 kg/m2 to <25 kg/m2. Binary logistic regression analysis was performed to identify factors associated with obesity and overweight.ResultsThe prevalence of obesity and overweight was 21.0% and 32.2% in patients with BD, respectively. Compared to patients with overweight and normal weight, patients with obesity were older, had a longer duration of BD and a longer length of hospital stay, had a higher prevalence of diabetes and hypertension, and had a higher level of all metabolic indices, except for HDL cholesterol. Binary logistic regression analysis showed that duration of BD, uric acid, alanine aminotransferase (ALT), triglyceride, and LDL cholesterol were significantly associated with obesity, and male sex and uric acid level were significantly associated with overweight (p < 0.05).ConclusionsObesity and overweight were fairly prevalent in Chinese BD patients, and several factors were related to obesity and overweight. The results of the present study call for the need to implement early screening, prevention and interventions for obesity and overweight in patients with BD in China.

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“…It has also been found that BD-related microbiota, such as Citrobacter spp. and Phascolarctobacterium spp., can synthesize corresponding neuroactive metabolites, which are potential markers associated with hallmarks of functional connectivity in brain networks, and imply abnormal cognitive function, emotion regulation, and interoception (Li et al, 2022). In studies of ASD, when gut microbiota from human donors with ASD were transplanted into germ-free mice, their brains showed alternative splicing of ASD-related genes that induced signature autistic behaviors.…”

Section: Il-6mentioning

confidence: 99%

“…Recent studies also suggest that elevated levels of fasting blood glucose and triglyceride may be associated with cognitive dysfunction in BD patients. Improving glucose and lipid metabolism in BD patients may help improve some specific areas of cognitive function ( Qiu et al, 2022 ). In ASD subjects, the rate of glucose metabolism in parietal, prefrontal motor and eye areas and amygdala was decreased, which may be related to cognitive tasks ( Mitelman et al, 2018 ).…”

Section: Metabolism and Microbiome-gut-brain Axismentioning

confidence: 99%

Cognitive impairment in psychiatric diseases: Biomarkers of diagnosis, treatment, and prevention

Wang

Meng

Liu

et al. 2022

Front. Cell. Neurosci.

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Psychiatric diseases, such as schizophrenia, bipolar disorder, autism spectrum disorder, and major depressive disorder, place a huge health burden on society. Cognitive impairment is one of the core characteristics of psychiatric disorders and a vital determinant of social function and disease recurrence in patients. This review thus aims to explore the underlying molecular mechanisms of cognitive impairment in major psychiatric disorders and identify valuable biomarkers for diagnosis, treatment and prevention of patients.

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Association between abnormal glycolipid level and cognitive dysfunction in drug-naïve patients with bipolar disorder

Cited by 12 publications

References 51 publications

Characterization of circRNA-Associated-ceRNA Networks Involved in the Pathogenesis of Postoperative Cognitive Dysfunction in Aging Mice

Characterization of circRNA-Associated-ceRNA Networks Involved in the Pathogenesis of Postoperative Cognitive Dysfunction in Aging Mice

Prevalence and associated factors of obesity and overweight in Chinese patients with bipolar disorder

Cognitive impairment in psychiatric diseases: Biomarkers of diagnosis, treatment, and prevention

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