Association between ABO and Rhesus Blood Group Systems among Confirmed Human T Lymphotropic Virus Type 1-Infected Patients in Northeast Iran

Ayatollahi, Hossein; Rafatpanah, Houshang; Khayyami, Masoud; Sayyadpour, D.; Ravarian, M.; Sadeghian, Mohammad Hadi; Izadi, Nabiallah; Khoob, Mahdi Khabbaz

doi:10.1089/aid.2008.0002

Cited by 11 publications

(6 citation statements)

References 23 publications

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“…Similarly studies carried out in Enugu by Nneli and colleagues [ 38 ] and in Adamawa State by Abdulazeez and colleagues [ 39 ] indicated that HIV positivity was more predominant among group O subjects. Similarly, a study to investigate the distribution of ABO and Rhesus blood group types in 984 randomly selected human T lymphotropic virus-1(HTLV-1)-infected blood donors observed that donors who are AB+ have increased risk of HTLV-1 infection [ 40 ]. The reason for this predisposition may be genetic or it may also be due to the fact that blood group O is the most prevalent ABO blood groups among blacks and Caucasians.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of p24 antigen among a cohort of HIV antibody negative blood donors in Sokoto, North Western Nigeria - the question of safety of blood transfusion in Nigeria

Erhabor¹,

Mohammed²,

Zama³

et al. 2014

Pan Afr Med J

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IntroductionBlood transfusions remain a substantial source of HIV in SSA particularly among children and pregnant women. Aims and objectives: This aim of this retrospective study was to investigate the prevalence of p24 antigen among HIV antibody seronegative blood donors in Sokoto, North West Nigeria.MethodsA total of 15,061 HIV antibody negative blood donors with mean age and age range (29.2 ± 8.18 and 18-50 years) were screened for p24 antigen between January 2010 to July 2013 using the Diapro Diagnostic immunoassay kit for P24 antigen (King Hawk Pharmaceuticals Beijing China).ResultsThe overall prevalence of p24 antigen among the HIV antibody negative donors sample was 5.84%. The yearly prevalence was 9.79, 8.12, 2.7 and 2.84% respectively in 2010, 2011, 2012 and 2013. Of the total number of blood donor tested, 14,968 (99.38%) were males while 93 (0.62%) were females. The prevalence of P24 antigen was significantly higher among male blood donors 873 (5.8%) compared to females 7(0.05%), (p= 0.001). P24 positivity was significantly higher among blood group O blood donors compared to A, B and AB donors (494 (3.29%) compared to 184 (1.89%), 196 (1.30%) and 6 (0.04%)) respectively, p = 0.001). The prevalence of P24 antigen was significantly higher among Rhesus positive blood donors compared to Rhesus negative (807 (5.36%) versus 73 (0.48%), p =0.001).ConclusionBlood transfusion in Nigeria is associated with increased risk of HIV transmission. There is the urgent need to optimize the screening of blood donors in Nigeria by the inclusion of p24 antigen testing into the blood donor screening menu. The Nigerian government urgently need to adopt the WHO blood safety strategies to reduce the risk of transmission of HIV through blood transfusion.

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Section: Discussionmentioning

confidence: 99%

Prevalence of p24 antigen among a cohort of HIV antibody negative blood donors in Sokoto, North Western Nigeria - the question of safety of blood transfusion in Nigeria

Erhabor¹,

Mohammed²,

Zama³

et al. 2014

Pan Afr Med J

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“…Other infectious diseases, such as Chagas’ disease and dengue fever, have a more aggressive and symptomatic course in AB-group individuals [22, 23]. Infection with HTLV-1 has also been more frequently observed in blood group AB [24]. A higher proportion of HIV-infected AB-group individuals could therefore develop symptoms earlier in life, which would consequently exclude them from blood donation.…”

Section: Discussionmentioning

confidence: 99%

The Higher Frequency of Blood Group B in a Brazilian Population with HIV Infection

Onsten¹,

Callegari-Jacques²,

Goldani³

2013

TOAIDJ

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Objective:To analyze the frequency of and odds for and against HIV infection based on ABO blood type in a large sample of blood donors.Background:Coevolution between pathogens and hosts may explain the ABO system of polymorphisms. HIV-infected cells add ABO(H) blood group antigens to the viral envelope. Naturally occurring antibodies against ABO(H) antigens that are present in normal human sera are able to neutralize ABO-expressing HIV in vitro. Blood donors are ideal for studying blood groups and HIV infection in vivo because all donors are routinely typed and tested.Methods:All blood donors who donated blood between 1994 and 2010 were tested for HIV (ELISA antibody tests and Western blot test or immunofluorescence testing) and were ABO typed (direct and reverse grouping tests). HIV infection based on the ABO blood group was analyzed using the chi-square test and game theory.Results:The total number of examined blood donors during this period was 271,410, of whom 389 were infected with HIV. B-group donors were more infected than non-B donors (p= 0.006).Conclusions:A more restricted antigen recognition capacity of anti-Galα1-3Gal in blood groups AB and B and a weaker antigen-binding capacity of anti-A antibodies may contribute to a higher frequency of HIV infection in blood group B.

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“…in subjects of northeast Iran. [20] It is obvious that more attention to quality control programs in blood banking laboratory is necessary especially for determination of weak D positive RBCs and reporting of D negative blood group. Furthermore antibody screening should be performed for Rh (D, C and E) antigens as the most common alloantibodies in all of the patients from the start of transfusion to reduce transfusion complications.…”

Section: Discussionmentioning

confidence: 99%

Alloimmunization among transfusion-dependent thalassemia patients

Sadeghian¹,

Keramati²,

Badiei³

et al. 2009

Asian J Transfus Sci

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Background:Thalassemia is a common hemoglobin disorder in Iran and one of the major public health problems. Although blood transfusions are lifesavers for thalassemia patients, they may be associated with some complications especially erythrocyte alloimmunization. The purpose of this study was to investigate the prevalence of red blood cell alloantibodies and to determine types of these antibodies among multiple-transfused thalassemic patients.Materials and Methods:A total of 313 thalassemia patients in the northeast of Iran, who received regular blood transfusion, were included in this study. Screening of antibodies was performed on fresh serum of all patients and then antibodies were identified in patients’ serum that had positive antibody screening test using a panel of recognized blood group antigens.Results:We identified 12 alloantibodies in 9 patients (2.87%) that all were against Rhesus (Rh) blood group antigens (D, C, E). Three patients developed 2 antibodies, and others had one antibody. The most common alloantibodies were Anti-D (88.88%) and followed by Anti-C and Anti-E. Higher frequency of alloimmunization was observed in female, Rh negative and splenectomized patients.Conclusion:This study showed that evaluation of the packed cells for Rh (C, E) from the start of transfusion can be helpful in decreasing the rate of alloantibody synthesis.

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Association between ABO and Rhesus Blood Group Systems among Confirmed Human T Lymphotropic Virus Type 1-Infected Patients in Northeast Iran

Cited by 11 publications

References 23 publications

Prevalence of p24 antigen among a cohort of HIV antibody negative blood donors in Sokoto, North Western Nigeria - the question of safety of blood transfusion in Nigeria

Prevalence of p24 antigen among a cohort of HIV antibody negative blood donors in Sokoto, North Western Nigeria - the question of safety of blood transfusion in Nigeria

The Higher Frequency of Blood Group B in a Brazilian Population with HIV Infection

Alloimmunization among transfusion-dependent thalassemia patients

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