Association between accumulation of visceral fat and the combination of .BETA.3 adrenergic receptor Trp64Arg, .BETA.2 adrenergic receptor Arg16Gly and uncoupling protein 1 -3826A&gt;G polymorphisms detected by Smart Amplification Process 2

Tsunekawa, Katsuhiko; Yanagawa, Yoshimaro; Aoki, Tomoyuki; Morimura, Tadashi; Araki, Osamu; Ogiwara, Takayuki; Kawai, Yosuke; Mitani, Yuichiro; Lezhava, Alexander; Yanagawa, Masumi; Hayashizaki, Yoshihide; Murakami, Masami

doi:10.1507/endocrj.ej11-0148

Cited by 14 publications

(16 citation statements)

References 18 publications

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“…The association between UCP1 -3826A/G and UCP3 -55C/T and BMI was replicated in the current study. The association between UCP1 -3826A/G and BMI contradicts previous studies conducted in the Japanese population (Hayakawa et al, 1999;Kahara et al, 2002;Kotani et al, 2008;Tsunekawa et al, 2011) with the exception of two studies (Matsushita et al, 2003;Nakano et al, 2006). It is worth noting that in the latter two studies, such association was inconsistent.…”

contrasting

confidence: 56%

UCP2 I/D Modulated Change in BMI During a Lifestyle Modification Intervention Study in Japanese Subjects

Mutombo

Yamasaki²,

Shiwaku³

2013

Genetic Testing and Molecular Biomarkers

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Aim: Polymorphisms in uncoupling protein (UCP) genes have been strongly associated with energy expenditure and obesity. This study aimed at investigating the effects of UCP gene polymorphisms (UCP1 -3826A/G, UCP2A/V, UCP2 I/D, and UCP3 -55C/T) on change in body mass index (BMI) during a lifestyle modification program in Japanese subjects. Results: Intervention induced a significant decrease in energy intake ( -8.6% -17.0%) and a significant increase in energy expenditure (7.7% -7.4%). As a result, participants experienced a significant decrease in their BMI of -1.8% -2.7%. In a multivariate regression analysis, only UCP2 D/I among the selected UCP gene polymorphisms was associated with a change in BMI independent of the effects of gender, age, baseline BMI, changes in energy intake, and expenditure. Further regression analysis revealed that, in contrast to the DD genotype group, the DI + II genotype group showed no significant association between weight loss and change in energy expenditure suggesting this polymorphism altered the effects of this parameter on change in BMI. Conclusion: The study found UCP2 D/I to be associated with change in BMI by altering the effect of change in energy expenditure on change in BMI.

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contrasting

confidence: 56%

UCP2 I/D Modulated Change in BMI During a Lifestyle Modification Intervention Study in Japanese Subjects

Mutombo

Yamasaki²,

Shiwaku³

2013

Genetic Testing and Molecular Biomarkers

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“…43,44 Similarly, in another survey, an interaction was described between changes in fat mass and abdominal adiposity during a training program and ADRB3 polymorphism-Trp64Arg and ADRB2 polymorphism-Arg16Gly. 45 In a study by Tsunekawa et al, 46 significant differences were observed between combinations of the ADRB3 polymorphisms Trp64Arg, ADRB2 Arg16Gly, and uncoupling protein 1 UCP1-3826 A/G (mitochondrial, proton carrier) and hip/ waist ratio.…”

mentioning

confidence: 94%

What the Genetic Background of Individuals with Asthma and Obesity Can Reveal: Is β2-Adrenergic Receptor Gene Polymorphism Important?

Danielewicz

2014

Pediatric Allergy, Immunology, and Pulmonology

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“…Additionally, accurate amplification is achieved by reduction of nonspecific amplification using a unique asymmetrical primer set. Because the SmartAmp2 method is a simple and reliable method to detect mutations, it is often utilized in clinical settings, for example, for highly sensitive detection of the EGFR mutation in lung cancer [18], rapid and highly sensitive detection of the 2009 pandemic influenza A (H1N1) virus [19], and simple detection of multiple polymorphisms of the β 3AR , β 2AR , and UCP1 genes in many subjects [10]. Notably, the SmartAmp2 method enables us to analyze mutations using a drop of whole blood and the dried blood spot.…”

Section: Discussionmentioning

confidence: 99%

“…Participants were recruited from an ongoing health survey for the evaluation of metabolic syndrome and glucose tolerance in six areas in Gunma Prefecture, Japan: Maebashi City, Shibukawa City, Ogo Town, Gunma Town, Nakanojo Town, and Yoshioka Town [9, 10]. We studied 429 participants (156 men, aged 26–89 years; 273 women, aged 22–83 years) without a significant goiter who had not been found to have thyroid disease based on interviews concerning lifestyle habits and medical history.…”

Section: Methodsmentioning

confidence: 99%

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Frequency and Clinical Implication of the R450H Mutation in the Thyrotropin Receptor Gene in the Japanese Population Detected by Smart Amplification Process 2

Tsunekawa

Yanagawa

Aoki

et al. 2014

BioMed Research International

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In Japanese pediatric patients with thyrotropin (TSH) resistance, the R450H mutation in TSH receptor gene (TSHR) is occasionally observed. We studied the frequency and clinical implication of the R450H mutation in TSHR in the general population of Japanese adults using smart amplification process 2 (SmartAmp2). We designed SmartAmp2 primer sets to detect this mutation using a drop of whole blood. We analyzed thyroid function, antithyroid antibodies, and this mutation in 429 Japanese participants who had not been found to have thyroid disease. Two cases without antithyroid antibodies were heterozygous for the R450H mutation in TSHR. Thus, the prevalence of this mutation was 0.47% in the general population and 0.63% among those without antithyroid antibodies. Their serum TSH concentrations were higher than the average TSH concentration not only in subjects without antithyroid antibodies but also in those with antithyroid antibodies. The R450H mutation in TSHR is relatively common in the Japanese population and potentially affects thyroid function. The present study demonstrates that the SmartAmp2 method is useful to detect the R450H mutation in TSHR, which is one of the common causes of TSH resistance in the Japanese population.

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Association between accumulation of visceral fat and the combination of .BETA.3 adrenergic receptor Trp64Arg, .BETA.2 adrenergic receptor Arg16Gly and uncoupling protein 1 -3826A>G polymorphisms detected by Smart Amplification Process 2

Cited by 14 publications

References 18 publications

UCP2 I/D Modulated Change in BMI During a Lifestyle Modification Intervention Study in Japanese Subjects

UCP2 I/D Modulated Change in BMI During a Lifestyle Modification Intervention Study in Japanese Subjects

What the Genetic Background of Individuals with Asthma and Obesity Can Reveal: Is β2-Adrenergic Receptor Gene Polymorphism Important?

Frequency and Clinical Implication of the R450H Mutation in the Thyrotropin Receptor Gene in the Japanese Population Detected by Smart Amplification Process 2

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