Association between ACE gene polymorphism and carotid stenosisand and construction of related gene regulatory networks

Abstract

ObjectiveTo investigate the association between DD, ID and II genotypes of ACE gene and carotid stenosis, and to construct a network of ACE-related genes regulating carotid stenosis.ApproachesMeta-analysis was used to study the association between three genotypes DD, ID and II of carotid stenosis susceptibility gene ACE; functional annotation of ACE gene was conducted by GO analysis; and a network of ACE-related genes that regulate the mechanisms of carotid stenosis was established.ResultsMeta-analysis showed that DD and II genotypes of ACE gene were associated with carotid stenosis. GO analysis showed that the main biological processes involved in ACE include: the process of transforming angiotensinogen into mature angiotensin; angiotensin’s mediation of the brain's response to alcohol consumption and thirst control; any chemical reaction involving the regulation of angiotensin; and the process of catalyzing the release of a C-terminal dipeptide from a polypeptide chain. A network of ACE gene regulation of carotid stenosis was constructed in combination with KEGG analysis.ConclusionThe ACE gene is a susceptibility gene for carotid stenosis. Through the functional annotation and pathway analysis of ACE gene, an ACE gene-involved carotid stenosis regulatory mechanisms network was constructed.

Association analysis and expression level of ACE polymorphisms with egg-laying trait in Taihang chicken

“…As one of the important regulators, ACE plays an important function in lung tissues, and its homolog ACE2 is highly expressed in endothelial cells of the lung, contributing to the maintenance of normal function and development of nonadherence ( Gintoni et al, 2022 ). In the carotid artery, ACE is involved in the mechanism that regulates carotid stenosis and affects the regulation of the carotid artery to the brain ( He et al, 2019 ). In cardiac tissue, ACE alters the homeostasis of the local renin-angiotensin system and has a protective effect on the heart ( Bukowska et al, 2017 ).…”

miR-28-5p improved carotid artery stenosis by regulating vascular smooth muscle cell proliferation and migration

“…3 Nevertheless, the proliferation and migration of vascular smooth muscle cells (VSMCs) promoted the thickening of the local intima and accelerated the progression of asymptomatic CAS. 4 Therefore, diagnosis of patients at high risk of asymptomatic CAS in the early stage can contribute to the development of reasonable and effective treatment plans and reduce the risk of stroke. Although digital subtraction angiography is the gold standard for diagnosis of CAS, there is a risk of complications.…”