Association between ACE1 and missed abortion: ACE1 promotes H2O2-induced trophoblast cell injury in vitro
Yi-dan Yan,
Wen-xia Ji,
Na Zhao
et al.
Abstract:The aim of this study was to evaluate the role of angiotensin-converting enzyme 1 (ACE1) in H2O2-induced trophoblast cell injury and the potential molecular mechanisms. Oxidative stress was modeled by exposing HTR-8/SVneo cells to 200 μM H2O2. Western blot and real-time quantitative PCR methods were used to detect protein and mRNA expression level of ACE1 in chorionic villus tissue and trophoblast HTR-8/SVneo cell. Inhibition of ACE1 expression was achieved by transfection with small interfering RNA. Then flow… Show more
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