Association between Administration of Systemic Corticosteroids and the Recovery of Olfactory and/or Gustatory Functions in Patients with COVID-19: A Prospective Cohort Study

Gamil, Yasmine; Ismail, Radwa; Abdou, Ahmed; Shabaan, Alshaimaa Ahmed; Hamed, Mohamed G.

doi:10.3889/oamjms.2022.8599

Cited by 5 publications

(3 citation statements)

References 21 publications

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“…Gamil et al [ 40 ] conducted a prospective cohort study to confirm the effect of systemic corticosteroids on COVID-19-associated taste disorders. Among a total of 80 study participants (female: 51.3%, age: 18–67 years), 67 COVID-19 patients who were diagnosed with the RT-PCR test and who presented with ageusia were recruited.…”

Section: Resultsmentioning

confidence: 99%

Treatments of COVID-19-Associated Taste and Saliva Secretory Disorders

Tsuchiya

2023

Dentistry Journal

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Since the worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, treating taste and saliva secretory disorders associated with coronavirus disease 2019 (COVID-19) has become a critical issue. The aim of the present study was to update information on treatments applicable to such oral symptoms and discuss their pathogenic mechanisms. The literature search indicated that different treatments using tetracycline, corticosteroids, zinc, stellate ganglion block, phytochemical curcumin, traditional herbal medicine, nutraceutical vitamin D, photobiomodulation, antiviral drugs, malic acid sialagogue, chewing gum, acupuncture, and/or moxibustion have potential effects on COVID-19-associated ageusia/dysgeusia/hypogeusia and xerostomia/dry mouth/hyposalivation. These treatments have multiple modes of action on viral cellular entry and replication, cell proliferation and differentiation, immunity, and/or SARS-CoV-2 infection-induced pathological conditions such as inflammation, cytokine storm, pyroptosis, neuropathy, zinc dyshomeostasis, and dysautonomia. An understanding of currently available treatment options is required for dental professionals because they may treat patients who were infected with SARS-CoV-2 or who recovered from COVID-19, and become aware of their abnormal taste and salivary secretion. By doing so, dentists and dental hygienists could play a crucial role in managing COVID-19 oral symptoms and contribute to improving the oral health-related quality of life of the relevant patients.

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Section: Resultsmentioning

confidence: 99%

Treatments of COVID-19-Associated Taste and Saliva Secretory Disorders

Tsuchiya

2023

Dentistry Journal

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“…A sample calculation (STATA V16.0) performed using data from a previous study showed that a total of 32 patients would need to be included for a study power of 80% at an alpha of 0.05. However, this study included a total of 36 patients (18 in each group) to account for any possible dropouts [ 18 ].…”

Section: Methodsmentioning

confidence: 99%

Diode laser in management of loss of taste sensation in patients with post-COVID syndrome: a randomized clinical trial

Shabaan

Kassem²,

Mahrous

et al. 2023

BMC Oral Health

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Objective Loss of taste (ageusia) is a symptom observed following recovery from COVID-19 infection. The loss of taste and smell sensation may negatively affect patients’ quality of life (QoL). The present study aimed to evaluate the effectiveness of the Diode Laser in managing loss of taste sensation in patients with post-COVID syndrome versus the placebo. Material and method The study sample was 36 patients who complained of persistent loss of taste sensation following COVID-19. The patients were randomly assigned to one of the two groups according to the received treatment: Group I (laser treatment) and Group II (light treatment), with each patient receiving a diode laser treatment or placebo from the same operator. Taste sensation was subjectively measured after treatment for four weeks. Results The results demonstrated a significant difference between both groups regarding taste restoration after one month (p = 0.041), with Group II having a significantly higher percentage of cases 7 (38.9%) with partial taste restoration. In contrast, a significantly higher proportion of Group I 17 cases (94.4%) had complete taste restoration (p < 0.001). Conclusion The present study concluded that using a Diode laser 810 nm aided in a more rapid recovery from loss of taste dysfunction.

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“…Gamil et al [67] conducted a prospective cohort study to confirm the effect of systemic corticosteroid on COVID-19-associated taste disorders. Among a total of 80 study participants (female: 51.3%, age: 18-67 years), 67 COVID-19 patients who were diagnosed by the RT-PCR test and presented with ageusia were recruited.…”

Section: Treatment With Corticosteroid and Outcomementioning

confidence: 99%

Treatments of COVID-19-Associated Taste and Saliva Secretory Disorders

Tsuchiya¹

2023

Preprint

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Since the worldwide spread of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), treating taste and saliva secretory disorders associated with coronavirus disease 2019 (COVID-19) has become one of the most critical issues in the COVID-19 era. The aim of the present study was to update information on treatments being applicable to such oral symptoms and discuss their pathogenic mechanisms. Promising treatments include different types of methods using tetracycline, corticosteroid, zinc, stellate ganglion block, phytochemical curcumin, traditional herbal medicine, nutraceutical vitamin D, photobiomodulation, antiviral drug, malic acid sialagogue, chewing gum, acupuncture, and/or moxibustion. At present, however, fully validated treatments are still lacking for COVID-19-associated ageusia/dysgeusia/hypogeusia and xerostomia/dry mouth/hyposalivation. An appropriately selected treatment and oral healthcare should be provided to COVID-19 patients and survivors suffering from taste and saliva secretory disorders. Understanding of currently available treatment options is required for dental profes-sionals because they not only experience patients who were infected with SARS-CoV-2 or recov-ered from COVID-19 but first become aware of their abnormal taste and salivary secretion. By doing so, dentists and dental hygienists can play a crucial role in managing COVID-19-associated oral symptoms and contribute to improving the oral health-related quality of life of the relevant dental patients.

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Association between Administration of Systemic Corticosteroids and the Recovery of Olfactory and/or Gustatory Functions in Patients with COVID-19: A Prospective Cohort Study

Cited by 5 publications

References 21 publications

Treatments of COVID-19-Associated Taste and Saliva Secretory Disorders

Treatments of COVID-19-Associated Taste and Saliva Secretory Disorders

Diode laser in management of loss of taste sensation in patients with post-COVID syndrome: a randomized clinical trial

Treatments of COVID-19-Associated Taste and Saliva Secretory Disorders

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