Association between age at menarche and autistic traits in Turkish university students

Hergüner, Arzu; Hergüner, Sabri̇

doi:10.1002/ajhb.22739

Cited by 13 publications

(13 citation statements)

References 37 publications

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“…Two prior findings, association between early AAM and PD 1 , 2 and positive correlation between autistic traits and AAM, 31 would suggest finding lower autistic traits in women with PD, contrary to the results of this study. In our sample, AAM was lower in women with PD; however, this difference was not significant.…”

Section: Discussioncontrasting

confidence: 99%

“… 30 Recently, an association between higher autistic traits and delayed menarche was reported in nonclinical female university students. 31 Ingudomnukul et al 14 and Pohl et al 15 have demonstrated the relationship between autism and dysmenorrhea in clinically diagnosed ASD samples. The current study found a similar association in typically developing females.…”

Section: Discussionmentioning

confidence: 99%

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Autistic traits in women with primary dysmenorrhea: a case–control study

Toy¹,

Hergüner²,

S³

et al. 2016

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ObjectivesRecent studies have shown that women with autism spectrum disorder have higher rates of menstrual problems, including irregular menstrual cycles, unusually painful periods (dysmenorrhea), and excessive menstrual bleeding. In this study, we investigated the autistic traits in female university students with primary dysmenorrhea (PD).MethodsSeventy females with PD and 70 females without PD were enrolled in the study. The Autism Spectrum Quotient (AQ) was used to measure autistic traits and the Brief Symptom Inventory was used for evaluating anxiety and depression levels. The dysmenorrheal pain was assessed by visual analog scale (VAS), coded from 0 to 10. Weight and height were measured, and the body mass index was calculated.ResultsThere were no statistical differences between the groups in terms of age, duration of education, and body mass index. Women with PD had higher AQ – Total, and AQ – Attention Switching subscale scores than subjects without PD. Spearman analysis revealed that AQ – Total and AQ – Attention Switching scores were correlated with VAS. According to the linear regression analysis, VAS was predicted only by AQ – Attention Switching subscale.ConclusionOur findings showed an association between autistic traits and dysmenorrhea in typically developing females.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Autistic traits in women with primary dysmenorrhea: a case–control study

Toy¹,

Hergüner²,

S³

et al. 2016

NDT

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“…It is plausible that as the sample matures, other more relevant findings related to pubertal onset may emerge altering the interpretation of these findings. For example, some previous studies have found delayed pubertal onset [Harper & Collins, 1979;Herguner & Herguner, 2016;Knickmeyer et al, 2006;Whitehouse et al, 2011] or no differences in pubertal timing [May et al, 2017]. Therefore, results from the current study must be interpreted with reasonable caution.…”

Section: Discussionmentioning

confidence: 67%

Pubertal Timing During Early Adolescence: Advanced Pubertal Onset in Females with Autism Spectrum Disorder

et al. 2020

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Autism spectrum disorder (ASD) is characterized by impaired social communication and poor adaptation to change; thus, the onset of puberty may be a pivotal transition. This cross-sectional study measured pubertal timing to examine hypothesized differences for sex (female vs. male) and group (ASD vs. typical development [TD]). Participants included 239 children (137 ASD, 102 TD) between 10 and 13 years. The ASD group included 35 females and 102 males; the TDs included 44 females and 58 males. Pubertal onset measured by genital or pubic stage was investigated with linear regression using main effects of sex and age-by-sex interactions in TD and ASD groups and main effects of diagnosis and diagnosis-by-age interactions in males and females, controlling for body mass index, socioeconomic status, and race. In TD, examination of main effects for genital (penis/breast) stage showed no difference for male and female children (t = 1.33, P = 0.187, rdf = 92); however, there were significant differences in ASD (t = 2.70, P = 0.008, rdf = 121). For diagnosis modeled separately by sex, there was significantly earlier pubertal development in females with ASD (t = 1.97, P = 0.053, rdf = 70, but not males (t = 1.329, P = 0.186, rdf = 143). In addition, analysis of menses revealed females with ASD had significantly earlier onset than TD (t = −2.56, P = 0.018, rdf = 21). Examination of pubic stage revealed expected sex differences for TD (t = 2,674, P = 0.009, rdf = 91) and ASD (t = 3.482, P = 0.001, rdf = 121). Females with ASD evidence advanced pubertal onset relative to ASD males and TD females. Findings underscore the need for enhanced understanding of pubertal development in ASD, as differences may have significant psychological, social, physiological, and developmental consequences.

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“…Likewise, an increase in premenstrual syndrome has been observed in women with ASD (Obaydi and Puri, 2008; Hamilton et al, 2011), who are more likely to exhibit behavioral issues related to the onset of periods (Burke et al, 2009). In addition, delayed age of menarche seems to correlate with the severity of autistic traits (Hergüner and Hergüner, 2016). These findings lend support to the androgen theory of ASD, according to which elevated levels of testosterone during fetal development may contribute to the development of ASD.…”

Section: Domestic Traits In the Asd Phenotypementioning

confidence: 99%

Language Impairments in ASD Resulting from a Failed Domestication of the Human Brain

2016

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Autism spectrum disorders (ASD) are pervasive neurodevelopmental disorders entailing social and cognitive deficits, including marked problems with language. Numerous genes have been associated with ASD, but it is unclear how language deficits arise from gene mutation or dysregulation. It is also unclear why ASD shows such high prevalence within human populations. Interestingly, the emergence of a modern faculty of language has been hypothesized to be linked to changes in the human brain/skull, but also to the process of self-domestication of the human species. It is our intention to show that people with ASD exhibit less marked domesticated traits at the morphological, physiological, and behavioral levels. We also discuss many ASD candidates represented among the genes known to be involved in the “domestication syndrome” (the constellation of traits exhibited by domesticated mammals, which seemingly results from the hypofunction of the neural crest) and among the set of genes involved in language function closely connected to them. Moreover, many of these genes show altered expression profiles in the brain of autists. In addition, some candidates for domestication and language-readiness show the same expression profile in people with ASD and chimps in different brain areas involved in language processing. Similarities regarding the brain oscillatory behavior of these areas can be expected too. We conclude that ASD may represent an abnormal ontogenetic itinerary for the human faculty of language resulting in part from changes in genes important for the “domestication syndrome” and, ultimately, from the normal functioning of the neural crest.

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Association between age at menarche and autistic traits in Turkish university students

Abstract: These findings suggest that there may be a common developmental mechanism between delayed menarche and autistic traits, possibly through elevated levels of prenatal androgens.

Cited by 13 publications

References 37 publications

Autistic traits in women with primary dysmenorrhea: a case–control study

Autistic traits in women with primary dysmenorrhea: a case–control study

Pubertal Timing During Early Adolescence: Advanced Pubertal Onset in Females with Autism Spectrum Disorder

Language Impairments in ASD Resulting from a Failed Domestication of the Human Brain

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Association between age at menarche and autistic traits in Turkish university students

Abstract: These findings suggest that there may be a common developmental mechanism between delayed menarche and autistic traits, possibly through elevated levels of prenatal androgens.

Cited by 13 publications

References 37 publications

Autistic traits in women with primary dysmenorrhea: a case&ndash;control study

Autistic traits in women with primary dysmenorrhea: a case&ndash;control study

Pubertal Timing During Early Adolescence: Advanced Pubertal Onset in Females with Autism Spectrum Disorder

Language Impairments in ASD Resulting from a Failed Domestication of the Human Brain

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Autistic traits in women with primary dysmenorrhea: a case–control study

Autistic traits in women with primary dysmenorrhea: a case–control study