Association between Air Pollution and the Development of Rheumatic Disease: A Systematic Review

Sun, Gavin R.; Hazlewood, Glen; Bernatsky, Sasha; Kaplan, Gilaad G.; Eksteen, Bertus; Barnabe, Cheryl

doi:10.1155/2016/5356307

Cited by 51 publications

(35 citation statements)

References 26 publications

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“…It has been reported that the immunotoxicity of PM plays an important role in the innate immune system and in cellular or humoral immunity [ 21 ]. Ambient PM 2.5 -related skin damage might be caused by activating the innate immune system.…”

Section: Discussionmentioning

confidence: 99%

Effects of Ambient Fine Particles PM2.5 on Human HaCaT Cells

Qiao

Kang

Jiang

et al. 2017

IJERPH

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The current study was conducted to observe the effects of fine particulate matter (PM2.5) on human keratinocyte cell line (HaCaT) cells. The potential mechanism linking PM2.5 and skin was explored. HaCaT cells were cultured and then accessed in plate with PM2.5. Cell viability was tested by Cell Counting Kit-8. The mRNA and protein expression of Filaggrin, Loricrin, Involucrin, and Repetin were analyzed. The levels of Granulocyte-macrophage Colony Stimulating Factor, Thymic Stromal Lymphopoietin, Tumor Necrosis Factor-α, Interleukin-1α, and Interleukin-8 were detected in the supernatant of the HaCaT cell with enzyme-linked immunosorbent assay kits. Cell viability decreased with the increase in PM2.5. Compared with the control group, the protein expression of Filaggrin, Repetin, Involucrin, and Loricrin showed different expression patterns in PM2.5 treatment groups. The level of Tumor Necrosis Factor-α, Thymic Stromal Lymphopoietin, Interleukin-1α, and Interleukin-8 significantly increased in the cells treated with PM2.5. Ambient PM2.5 may increase the risk of eczema and other skin diseases. The relative mechanism may be associated with the impairment of the skin barrier and the elevation of inflammatory responses.

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Section: Discussionmentioning

confidence: 99%

Effects of Ambient Fine Particles PM2.5 on Human HaCaT Cells

Qiao

Kang

Jiang

et al. 2017

IJERPH

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“…asthma, chronic bronchitis, rhinitis) [ 3 ]. Recent evidence supports associations with diabetes [ 21 ], rheumatic diseases [ 22 ], cognitive functioning [ 23 ] and neurodegenerative diseases [ 24 ]. Furthermore, gases such as the secondary pollutant ozone are related to all-cause, circulatory and respiratory mortalities [ 3 , 25 ] as well as chronic respiratory diseases such as asthma [ 3 ].…”

Section: Interactions Between Climate Air Pollution and Healthmentioning

confidence: 97%

The Interplay of Climate Change and Air Pollution on Health

Orru

Ebi

Forsberg

2017

Curr Envir Health Rpt

329

162

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Purpose of ReviewAir pollution significantly affects health, causing up to 7 million premature deaths annually with an even larger number of hospitalizations and days of sick leave. Climate change could alter the dispersion of primary pollutants, particularly particulate matter, and intensify the formation of secondary pollutants, such as near-surface ozone. The purpose of the review is to evaluate the recent evidence on the impacts of climate change on air pollution and air pollution-related health impacts and identify knowledge gaps for future research.Recent FindingsSeveral studies modelled future ozone and particulate matter concentrations and calculated the resulting health impacts under different climate scenarios. Due to climate change, ozone- and fine particle-related mortalities are expected to increase in most studies; however, results differ by region, assumed climate change scenario and other factors such as population and background emissions.SummaryThis review explores the relationships between climate change, air pollution and air pollution-related health impacts. The results highly depend on the climate change scenario used and on projections of future air pollution emissions, with relatively high uncertainty. Studies primarily focused on mortality; projections on the effects on morbidity are needed.

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“…Air pollutants are part of the environmental components resulting from dust storms and fossil fuel combustion, which determine RA symptoms and worsen the overall disease. Additionally, gases such as SO 2 , NO 2 , carbon monoxide (CO), and O 3 are the other main pollutants that cause RA [8]. More in general, extensive investigations have been performed by several researchers about the impact of ambient air pollution on human health [9,10].…”

Section: Introductionmentioning

confidence: 99%

Influence of Ambient Air Pollution on Rheumatoid Arthritis Disease Activity Score Index

Alsaber

Pan

Al‐Herz

et al. 2020

IJERPH

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Rheumatoid arthritis (RA) is a chronic autoimmune of an unknown etiology. Air pollution has been proposed as one of the possible risk factors associated with disease activity, although has not been extensively studied. In this study, we measured the relationship between exposure to air pollutants and RA activity. Data on RA patients were extracted from the Kuwait Registry for Rheumatic Diseases (KRRD). Disease activity was measured using disease activity score with 28 examined joints (DAS-28) and the Clinical Disease Activity Index (CDAI) during their hospital visits from 2013 to 2017. Air pollution was assessed using air pollution components (PM 10 , NO 2 , SO 2 , O 3 , and CO). Air pollution data were obtained from Kuwait Environmental Public Authority (K-EPA) from six different air quality-monitoring stations during the same period. Multiple imputations by the chained equations (MICE) algorithm were applied to estimate missing air pollution data. Patients data were linked with air pollution data according to date and patient governorate address. Descriptive statistics, correlation analysis, and linear regression techniques were employed using STATA software. In total, 1651 RA patients with 9875 follow-up visits were studied. We detected an increased risk of RA using DAS-28 in participants exposed to SO 2 and NO 2 with β = 0 . 003 (95% CI: 0.0004–0.005, p < 0 . 01 ) and β = 0 . 003 (95% CI: 0.002–0.005, p < 0 . 01 ), respectively, but not to PM 10 , O 3 , and CO concentrations. Conclusively, we observed a strong association between air pollution with RA disease activity. This study suggests air pollution as a risk factor for RA and recommends further measures to be taken by the authorities to control this health problem.

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Association between Air Pollution and the Development of Rheumatic Disease: A Systematic Review

Cited by 51 publications

References 26 publications

Effects of Ambient Fine Particles PM2.5 on Human HaCaT Cells

Effects of Ambient Fine Particles PM2.5 on Human HaCaT Cells

The Interplay of Climate Change and Air Pollution on Health

Influence of Ambient Air Pollution on Rheumatoid Arthritis Disease Activity Score Index

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