Association between aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism and susceptibility to colorectal cancer: a meta-analysis

et al. 2020

Sci Rep

the associations between genetic polymorphisms in ADH1B (rs1229984) and ALDH2 (rs671), alcohol consumption, the effect of a combination of the two polymorphisms, and breast cancer risk were studied in a population of East-Asian women. In this study, 623 breast cancer cases and 1845 controls, aged 40 or above, were included. The association between ALDH2 polymorphism and breast cancer risk was validated in 2143 breast cancer cases and 3977 controls. Alcohol consumption increased the risk of breast cancer regardless of ADH1B and ALDH2 genotypes. The rs671 polymorphism of ALDH2 was independently associated with increased breast cancer risk (oR = 1.27, 95% CI = 1.02-1.58 per increment of A). The ADH1B rs1229984 polymorphism, and combined effects of the rs671 and rs1229984 polymorphisms, did not reveal any significant association with breast cancer. Stratification by menopausal status revealed that rs671 gene polymorphisms were significantly associated with breast cancer only in postmenopausal women (oR = 1.45, 95% CI = 1.03-2.05 per increment of A). This is the first study to demonstrate an independent association between ALDH2 gene variants and breast cancer in Asian women. further studies are warranted to further elucidate the etiology of breast cancer as it relates to alcohol consumption in Asian women. open Scientific RepoRtS | (2020) 10:6564 | https://doi.population 12 , new studies exploring the associations and interactions among alcohol consumption, related ethanol-metabolizing genes, and breast cancer are warranted. Thus, in the present study, we investigated the association among genetic, functionally established single nucleotide polymorphisms (SNPs) in ADH1B (rs1229984) and ALDH2 (rs671), alcohol consumption, and their combined effects and breast cancer risk in an East-Asian population. Scientific RepoRtS |(2020) 10:6564 | https://doi. Statistical analysis.The relationship between alcohol consumption and breast cancer risk was assessed with a simple logistic regression and a multiple logistic regression adjusted for age at menarche, age at first full term pregnancy, age at menopause, body mass index, smoking status, and rs671/rs1229984 genotype. The relationship between rs671 genotype, rs1229984 genotype, and breast cancer risk was additionally assessed with a simple and a multiple logistic regression adjusted for age at menarche, age at first full term pregnancy, age at menopause, body mass index, smoking status, and alcohol consumption. To assess the association between each SNP and breast cancer, the codominant, dominant, and additive models were considered. In addition, the combined effects of rs671 and rs1229984 genotype on breast cancer were assessed. The ALDH2 and ADH1B genotypes and alcohol intake status were collectively studied to evaluate their combined effect on breast cancer risk. Stratified by ALDH2, ADH1B, and a combination of ALDH2/ADH1B genotypes, the association among alcohol consumption itself, daily alcohol intake, and breast cancer was evaluated with odds ratio (OR) and P-value. In ad...

Section: Discussionmentioning

confidence: 98%

Role of aldehyde dehydrogenases, alcohol dehydrogenase 1B genotype, alcohol consumption, and their combination in breast cancer in East-Asian women

Park

Kim

et al. 2020

Sci Rep

“…Such symptoms signify a buildup of toxic acetaldehyde in the body; toxic acetaldehyde that has been classified as a group one human carcinogen by the International Agency for Research on Cancer of the World Health Organization [12]. Malignancies associated with flushing include esophageal [13], gastric [14,15,16,17], colorectal [18,19,20], and stomach [21] cancers. Furthermore, researchers have stated that if moderate or heavy drinking flushers decreased their alcohol intake, more than 50% of esophageal squamous cell carcinomas could be prevented in East Asian samples [9].…”

Section: Introductionmentioning

confidence: 99%

Primary Reason for Drinking Among Current, Former, and Never Flushing College Students

et al. 2019

IJERPH

Alcohol consumption among individuals who experience a flushing response (reddening of the face, nausea, dizziness, headache, anxiety, and increased heartbeat) can result in serious health problems. However, studies on reasons for drinking among flushers, especially in the college context, are limited. Thus, this study investigated the association between primary reason for drinking and alcohol use among a nationally representative sample of current, former, and never flushing college students. The aim was to measure whether college students with current or former experience of facial flushing have different primary reasons for drinking compared to students with no experience of facial flushing. We surveyed and analyzed the data of 4590 students in a nationally representative sample of 82 colleges in South Korea. Multiple regression analysis was used to identify the association between primary reason for drinking and alcohol intake. Alcohol intake was measured using the Alcohol Use Disorders Identification Test (AUDIT). Among 1537 current (33.5%), 152 former (3.3%), and 2901 (63.2%) never flushers, mean AUDIT scores were 7.715 ± 5.434, 11.039 ± 6.405, and 10.465 ± 5.779, respectively. Current flushers had significantly higher AUDIT scores when drinking for pleasure (β = 2.696, p < 0.0001) or stress/depression (β = 2.578, p < 0.0001). Primary reasons for drinking were not associated with alcohol intake for former flushers. Never flushers had significantly higher AUDIT scores when drinking for pleasure (β = 2.696, p < 0.0001), stress/depression (β = 2.578, p < 0.0001), or boredom (β = 0.740, p = 0.029) than peer pressure. Our results suggest that former and never flushers consume higher amounts of alcohol on average than never flushers. For current flushers, drinking for pleasure or stress/depression may increase alcohol intake, while for never flushers, drinking for pleasure, stress/depression, as well as boredom may have the same effect.

“…For individuals with AFR, toxic acetaldehyde build-up can occur from the first sip of alcohol (Price et al, 2004) which is extremely dangerous as acetaldehyde build-up has been classified as a Group 1 human carcinogen by the International Agency for Research on Cancer of the World Health Organization (Salaspuro, 2011). Low-activity ALDH2 has been uniformly associated with various cancers including esophageal (Brooks et al, 2009, Cui et al, 2009, Gu et al, 2012, Liu et al, 2017, Matsuo et al, 2001, Wu et al, 2013, Yang et al, 2007, Yang et al, 2010, Yu et al, 2018, Zhang et al, 2010, gastric (Chen et al, 2016, Duell et al, 2012, Ghosh et al, 2017, Hidaka et al, 2015, Ishioka et al, 2018, Jiang et al, 2017, Wang et al, 2014, colorectal (Crous-Bou et al, 2013, Guo et al, 2013, Matsuo et al, 2006, Xinhua and Yanfei, 2017, Yang et al, 2009, Zhao et al, 2016, Zhong et al, 2016, and stomach (Matsuo et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Drinking motives and alcohol use among college students with the alcohol flush reaction

et al. 2018

Preprint

Background: This study investigated the relationship between drinking motives and alcohol use among a nationally representative sample of college students with the alcohol flush reaction (AFR).We surveyed and analyzed the data of 2,245 male and 2,326 female college students in a nationally representative sample of 82 colleges in South Korea. Methods:Of our study population, 725 males (32.3%) and 812 females (34.9%) reported to currently suffering from AFR. Multiple regression analysis was used to identify the association between drinking motives and drinking behavior, measured via the AUDIT.Results: Relative to drinking because of peer pressure, students drinking for pleasure (males: β = 2.622, p <.0001; females β = 2.769, p <.0001) or stress/depression (males: β = 2.479, p <.0001; females β = 2.489, p <.0001) had higher AUDIT scores. Among students drinking because of stress/depression, seniors (males: β = 3.603, p<.0001; females: β = 3.791, p = 0.000), smokers (males: β = 1.564, p = 0.000; females β = 1.816, p = 0.007) and/or liberal arts students (males: β = 6.1136, p<.0001; females β = 4.2105, p <.0001) consumed more alcohol than their peers. Relative to conformity motives, enhancement and coping motives were found to have a greater influence on alcohol intake among college students with alcohol flush reaction. Conclusion:Considering that the flush reaction can occur in AFR individuals after just one sip of wine, our results show that educators and policymakers must take action to deal with this problem.