Association between α1‑antitrypsin and acute coronary syndrome

Abstract

α1-antitrypsin (AAT) is a protein released as part of the anti-inflammatory response. It regulates the activity of serine proteinases and has a crucial role in the pathogenesis of acute coronary syndrome (ACS). The present study aimed to examine its role in patients with ACS. The plasma samples of 117 patients were collected at the Cardiology Department of the Affiliated Hospital of Youjiang Medical University (Baise, China). These included 46 cases of ACS (who met the diagnostic criteria for ACS and had ≥50% luminal stenosis of any coronary vessel), 35 cases of stable angina (SA; with ≥50% luminal stenosis of any coronary vessel but in a stable condition) and 36 normal healthy controls (subjects with no luminal stenosis in their coronary arteries). Plasma AAT protein concentrations were measured by ELISA and clinical data were collected. The plasma levels of AAT protein in patients with ACS were lower than those in controls and cases of SA (P<0.05), and the levels tended to decrease with the number of coronary artery lesions involved. There were no significant associations of the expression of plasma AAT protein and the number of diseased vessels in patients or the degree of stenosis. There was no correlation between the plasma protein levels of AAT and Gensini scores of patients with ACS. In conclusion, the plasma AAT protein levels in patients with ACS may contribute to the occurrence and development of coronary artery disease.

Sesamol attenuates bleomycin‐induced pulmonary toxicity and fibrosis in experimental animals

“…Many authors have also reported that inhibition of ERK pathway leads to amelioration of pulmonary fibrosis. [52] In line with the above reported data, it was observed in our study that administration of BLM increased the expression of ERK1/2 protein in experimental animals. Activated ERK levels were significantly reduced on treatment with sesamol as compared to BLM treated group (p < 0.001).…”

Analysis on the Multimedia Information Retrieval Algorithm Based on Enterprise Correlation Financial Analysis under the Background of Big Data

“…For big information such as fnancial accounting, simple classifcation methods can no longer meet the needs of users. Terefore, some scholars give a classifcation method according to the information labeling in the relational database to carry out labeling and classifcation so as to facilitate the public search, compared with traditional classifcation [17]. Te advantages and disadvantages of crowd classifcation are shown in Table 4.…”

Ceramides and pro-inflammatory cytokines for the prediction of acute coronary syndrome: a multi-marker approach

“…Emerging evidence suggests that an upregulated inflammatory response and abnormal metabolism of specific lipid molecules play significant roles in the formation, rupture and subsequent development of ACS. In addition to established traditional lipid biomarkers, such as low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C) and triglycerides (TGs), several metabolomic and lipidemic indicators, including ceramides and apolipoproteins, have been implicated in the occurrence and progression of ACS [ 3 – 5 ].…”