Association between angiotensin-converting enzyme I/D polymorphism and sepsis: A meta-analysis

Abstract

Our meta-analysis confirmed that the angiotensin-converting enzyme I/D polymorphism was associated with sepsis risk. However, the angiotensin-converting enzyme I/D polymorphism was not associated with sepsis mortality.

The association of angiotensin-converting enzyme gene polymorphism with respiratory distress syndrome in premature neonates

“…These findings matched with our results that there is no relationship between ACE polymorphism and sepsis. Also, Hou et al 23 elucidated no association between the I/D genotype and infant mortality, which enhances our results. However, during sepsis, ACE activity is decreased with the blood pressure.…”

“…19 Our findings are in line with those of Sivasli et al 14 , who reported that D/D and D-alleles were significantly higher in premature neonates without RDS than in neonates with RDS (43.5% and 68.5% vs. 26.8% and 47.6%, p<0.05), which suggested that D/D and D-alleles are protective factors from RDS in premature neonates. In contrast, Yimenicioglu et al 1 23 observed that D/D was a protective factor for sepsis in both the adult and pediatric populations in their meta-analysis study, and ACE inhibitor drugs may be harmful to patients with sepsis. These findings matched with our results that there is no relationship between ACE polymorphism and sepsis.…”

Relationship between angiotensin‐converting enzyme gene polymorphism and respiratory distress syndrome in premature neonates

“…Genotyping control quality was assessed by (i) analysing the correlation between the original and the duplicate genotype in 10% of the samples randomly chosen; and (ii) assessing the Hardy–Weinberg equilibrium .…”

Clinical Assays in Sepsis: Prognosis, Diagnosis, Outcomes, and the Genetic Basis of Sepsis

“…In ventilated low birth weight infants the ACE insertion/deletion (I/D) polymorphism does not have a significant effect on the incidence or outcome of sepsis [210,211]. Studies and meta-analyses showed that carriers of I allele (D/I genotype and I/I genotype) were at increased sepsis risk [212][213][214], but the polymorphism is not associated with outcome in critically ill septic patients [214,215]. With regard to ARDS, the data of Villar et al [216] do not support an association of the ACE gene I/D polymorphism with susceptibility or mortality in severe sepsis or with sepsisinduced ARDS in Spanish patients, but Cardinal-Fernandez et al demonstrated that the presence of the allele D of the ACE gene is associated with ARDS in patients with severe sepsis [217].…”

“…-Insertion/deletion (I/D) polymorphism does not have an effect on the incidence or outcome of sepsis in ventilated low birth infants [210,211] -Carriers of the I allele at increased sepsis risk [212][213][214] -I polymorphism not associated with outcome in critically ill septic patients [214][215][216] -The presence of the D allele is associated with ARDS in patients with severe sepsis [217] Sepsis…”