Association between Angiotensin I-Converting Enzyme Gene Polymorphism and Hypertension in Selected Individuals of the Bangladeshi Population

Morshed, M. Monzur; Khan, Haseena; Akhteruzzaman, Sharif

doi:10.5483/bmbrep.2002.35.3.251

Cited by 47 publications

(38 citation statements)

References 16 publications

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“…The frequency of this genotype among hypertensives in the current study (17.18%) was higher than that found for Malaysian and Bangladeshi individuals (10.76% and 11.40%, respectively); however, a Chinese population had a lower frequency. [27][28][29] The insertion and deletion alleles were significantly related to hypertension in the current study, which correlates with the findings of a similar North Indian study. 15 A positive correlation has been reported between various obesity variables like BMI and WHR, including oxidative stress markers such as reduced erythrocyte glutathione.…”

Section: Discussionsupporting

confidence: 82%

Association of Angiotensin-Converting Enzyme and Glutathione S-Transferase Gene Polymorphisms with Body Mass Index among Hypertensive North Indians

Rizvi

Raza

Siddiqi

et al. 2015

SQUMJ

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abstract:Objectives: This study aimed to examine the association of angiotensin-converting enzyme (ACE) and glutathione S-transferase (GST) gene polymorphisms with body mass index (BMI) in hypertensive North Indians. Methods: This case-control study was carried out between May 2013 and November 2014 at the Era's Lucknow Medical College & Hospital, Lucknow, India, and included 378 subjects divided into three groups. One group constituted 253 hypertensive individuals (sustained diastolic blood pressure of >90 mmHg and systolic blood pressure of >140 mmHg) who were subcategorised according to normal (<25 kg/m 2 ) or high (≥25 kg/m 2 ) BMI. The third group consisted of 125 age-, gender-and ethnically-matched normotensive controls with a normal BMI. Gene polymorphisms were evaluated by polymerase chain reaction. The genotypic and allelic frequency distribution among both groups were analysed. Results: A significant difference was found between GST theta 1-null and GST mu 1-positive genotype frequencies among the hypertensive overweight/obese individuals and controls (P = 0.014 and 0.033, respectively). However, no difference was observed in the frequency of ACE polymorphisms. ACE insertion/insertion genotype (P = 0.006), insertion and deletion alleles (P = 0.007 each) and GST theta 1-null and GST theta 1-positive genotypes (P = 0.006 each) were found to differ significantly between hypertensive cases and controls, regardless of BMI. Conclusion: ACE and GST gene polymorphisms were not associated with BMI but were significantly associated with hypertension among the studied group of North Indians.

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Section: Discussionsupporting

confidence: 82%

Association of Angiotensin-Converting Enzyme and Glutathione S-Transferase Gene Polymorphisms with Body Mass Index among Hypertensive North Indians

Rizvi

Raza

Siddiqi

et al. 2015

SQUMJ

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“…In 1998, Chowdhury et al found no association between ACE insertion/deletion (I/D) polymorphism and HTN in Bangladeshi population 29 whereas in 2002, Morshed et al 30 noted positive association between the two. Among the three ACE I/D variants, the DD genotype was associated with the highest value of both mean systolic and mean diastolic blood pressure (P ≤ 0.05) in men.…”

Section: Angiotensin-converting Enzyme Gene Polymorphismmentioning

confidence: 99%

“…In the overall population, blood pressure was highest in DD, intermediate in I/D, and the least in II subjects. 30 Further research is needed to clarify the issue.…”

Section: Angiotensin-converting Enzyme Gene Polymorphismmentioning

confidence: 99%

Hypertension in Bangladesh: a review

Islam

Majumder

2012

Indian Heart Journal

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A B S T R A C THypertension (HTN) is an increasingly important medical and public health problem. In Bangladesh, approximately 20% of adult and 40-65% of elderly people suffer from HTN. High incidence of metabolic syndrome, and lifestyle-related factors like obesity, high salt intake, and less physical activity may play important role in the pathophysiology of HTN. The association of angiotensin-converting enzyme (ACE) gene polymorphism and low birth weight with blood pressure has been studied inadequately. Studies have found relationship between mass arsenic poisoning and HTN. Hypovitaminosis D presumably plays role in the aetiopathogenesis of HTN in Bangladeshi population. South Asians appear to respond to antihypertensive therapy in a similar manner to the Whites. The latest National Institute for Health and Clinical Excellence guideline advocates a calcium-channel blocker as step 1 antihypertensive treatment to people aged ≥ 55 years and an ACE inhibitor or a low-cost angiotensin-II receptor blocker for the younger people. Calcium-channel blockers and beta-blockers have been found to be the most commonly prescribed antihypertensive drugs in Bangladesh. Non-adherence to the standard guidelines and irrational drug prescribing are likely to be important. On the other hand, non-adherence to antihypertensive treatment is quite high. At the advent of the new millennium, we are really unaware of our real situation. Large-scale, preferably, nation-wide survey and clinical research are needed to explore the different aspects of HTN in Bangladesh.

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“…The association between angiotensin converting enzyme (ACE) gene polymorphism and blood pressure has been studied inadequately in Bangladeshi population. 65,66 In 2002, Morshed et al found positive association between ACE insertion/ deletion (I/D) polymorphism and hypertension in Bangladeshi population. Among the three ACE I/D variants, the DD genotype was associated with the highest value of both mean systolic and mean diastolic blood pressure (p = <0.05) in men.…”

Section: Ethnicity and Geneticsmentioning

confidence: 99%

Cardiovascular Disease in Bangladesh: A Review

2017

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Abstract:Like elsewhere, cardiovascular disease (CVD) is an increasingly important cause of morbidity and mortality in Bangladesh. Over the past few decades, because of epidemiological transition, the prevailing disease pattern in this country changed from predominantly communicable to predominantly non-communicable disease, CVD contributes to the latter a lot. Actually, CVD particularly coronary artery disease (CAD) is getting epidemic proportion day by day. Hypertension and heart failure are on the rise, whereas the prevalence of acute rheumatic fever is declining. However, despite some efforts, reliable data concerning various aspects of CVD is inadequate at present. The current prevalence of hypertension, CAD, rheumatic fever and rheumatic heart disease and stroke may be 20-25%, 4-6%, <1/1000, 0.3-1.0% respectively. Besides conventional risk factors for different CVD, genetic predisposition and some novel issues like high salt intake, arsenicosis, hypovitaminosis D and air pollution may play important role in the aetiopathogenesis of CVD in this population. Formulation of appropriate policy and more emphasis on preventive strategy may help combat CVD in Bangladesh.

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Association between Angiotensin I-Converting Enzyme Gene Polymorphism and Hypertension in Selected Individuals of the Bangladeshi Population

Cited by 47 publications

References 16 publications

Association of Angiotensin-Converting Enzyme and Glutathione S-Transferase Gene Polymorphisms with Body Mass Index among Hypertensive North Indians

Association of Angiotensin-Converting Enzyme and Glutathione S-Transferase Gene Polymorphisms with Body Mass Index among Hypertensive North Indians

Hypertension in Bangladesh: a review

Cardiovascular Disease in Bangladesh: A Review

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