Association between Antenatal Antibiotic Exposure and Bronchopulmonary Dysplasia: A Systematic Review and Bayesian Model-Averaged Meta-Analysis

Abstract

<b><i>Introduction:</i></b> Antenatal antibiotic exposure has been suggested as a risk factor for bronchopulmonary dysplasia (BPD). We aimed to summarize the evidence from randomized controlled trials (RCTs) and observational studies on this potential association. <b><i>Methods:</i></b> PubMed/Medline and Embase databases were searched. BPD was classified as BPD28 (supplemental oxygen during 28 days or at postnatal day 28), BPD36 (supplemental oxygen at 36 weeks postmenstrual age), BPD36 or death, and BPD-associated pulmonary hypertension (BPD-PH). Bayesian model-averaged (BMA) meta-analysis was used to calculate Bayes factors (BFs). The BF<sub>10</sub> is the ratio of the probability of the data under the alternative hypothesis (H<sub>1</sub>) over the probability of the data under the null hypothesis (H<sub>0</sub>). <b><i>Results:</i></b> We included 6 RCTs and 27 observational studies (126,614 infants). Regarding BPD28, BMA showed that the evidence in favor of H<sub>0</sub> (lack of association with antenatal antibiotics) was weak for the RCTS (BF<sub>10</sub> = 0.506, 6 studies) and moderate for the observational studies (BF<sub>10</sub> = 0.286, 10 studies). Regarding BPD36, the evidence in favor of H<sub>0</sub> was moderate for the RCTs (BF<sub>10</sub> = 0.127, 2 studies) and weak for the observational studies (BF<sub>10</sub> = 0.895, 14 studies). Evidence in favor of H<sub>0</sub> was also weak for the associations with BPD36 or death (BF<sub>10</sub> = 0.429, 2 studies) and BPD-PH (BF<sub>10</sub> = 0.384, 2 studies). None of the meta-analyses showed evidence in favor of H<sub>1</sub>. <b><i>Conclusions:</i></b> The currently available evidence suggests a lack of association between antenatal antibiotics and BPD. However, our results should not be interpreted as an argument for widespread use of antibiotics in the setting of preterm delivery.