Association between aortic stiffness and left ventricular function in inflammatory bowel disease

Aslan, Abdullah Nabi; Sarı, Cenk; Sarı, Sevil Özer; Yürekli, Öykü Tayfur; Baştuğ, Serdal; Sivri, Serkan; Ersoy, Osman; Bozkurt, Engin

doi:10.5603/cj.a2016.0008

Cited by 20 publications

(21 citation statements)

References 30 publications

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“…2, Panel BeC). It is known that increased arterial stiffness leads to an early return of the reflected waves and augmentation of late systolic pressure, increased workload of the left ventricle and left ventricular hypertrophy [6]. Whether arterial stiffening is associated with eccentric or concentric left ventricular hypertrophy in patients with MetS is not clear.…”

Section: Discussionmentioning

confidence: 99%

“…We previously suggested that at least a part of the cardiovascular risk reported in patients with chronic inflammation could be mediated by an increase in aortic stiffness [3]. Aortic stiffness and reflected waves are increased in patients with chronic high-grade inflammation [4,5] and associated with left ventricular function [6]. An increase in aortic stiffness has been also reported in patients with MetS [7,8].…”

Section: Introductionmentioning

confidence: 97%

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Inflammation and ventricular-vascular coupling in hypertensive patients with metabolic syndrome

Zanoli

Pino

Terranova

et al. 2018

Nutrition, Metabolism and Cardiovascular Diseases

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Background and aims: Metabolic syndrome (MetS) is currently considered to raise the risk for type 2 diabetes and cardiovascular events. It has been suggested that part of this risk excess may be due to a cluster of additional factors associated with MetS. We aimed to investigate the role of inflammation on the ventricular-vascular coupling in patients with MetS. Methods and results: We enrolled a total of 227 hypertensive patients (106 with MetS and 121 without MetS) matched for age and gender. Aortic pulse wave velocity (aPWV), intima-media thickness (IMT) and high sensitivity C-reactive protein (CRP) increased according to the number of MetS components. Patients with MetS showed increased aPWV (11.5 AE 3.7 vs. 10.3 AE 2.5 m/s, P Z 0.03) compared with controls. In a model adjusted for age, sex, heart rate and mean blood pressure, aPWV resulted increased in patients with CKD (beta 1.29 m/s, 95%CI 0.61e1.96 m/s, P < 0.001) and MetS (beta 0.89 m/s, 95%CI 0.28e1.51 m/s, P Z 0.005). After additional adjustment for CRP and IMT, the slope of aPWV was respectively reduced by 16% and 62%, suggesting that inflammation and intima-media thickening could contribute to aortic stiffening in patients with MetS. In these patients, aPWV was also associated with left-ventricular mass index (beta 0.79 g/m 2.7 , 95%CI 0.05e1.52 g/m 2.7 , P Z 0.05). Conclusion: MetS is characterized by an inflammation-dependent acceleration in cardiovascular ageing. This pattern of pathophysiological abnormalities may contribute to amplify the burden of cardiovascular risk in patients with MetS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Inflammation and ventricular-vascular coupling in hypertensive patients with metabolic syndrome

Zanoli

Pino

Terranova

et al. 2018

Nutrition, Metabolism and Cardiovascular Diseases

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“…We previously proposed that this apparent contradiction, reported as “inflammatory bowel disease paradox,” could be at least in part explained by the chronic inflammation and consequent arterial stiffening . In this regard, a significant relationship between aortic stiffness and left ventricular systolic and diastolic dysfunction in patients with IBD has recently been reported . Here, we aimed to perform an individual participant data (IPD) meta‐analysis to determine whether patients with IBD have an increased aPWV after adjustment for major confounders, and to test whether inflammation is associated with aortic stiffening in this setting.…”

Section: Introductionmentioning

confidence: 99%

Inflammation and Aortic Stiffness: An Individual Participant Data Meta‐Analysis in Patients With Inflammatory Bowel Disease

Zanoli

Boutouyrie

Fatuzzo

et al. 2017

JAHA

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BackgroundThe recent finding that aortic pulse wave velocity (aPWV) is increased in patients with inflammatory bowel disease may explain why the cardiovascular risk is increased despite the low prevalence of traditional cardiovascular risk factors. We aimed to test whether inflammation is associated with aortic stiffening in this setting after adjustment for major confounders and to perform subgroup analyses.Methods and ResultsA systematic literature search for aPWV in inflammatory bowel disease was performed using PubMed, Scopus, Web of Science, and Google Scholar databases (last accessed May 7, 2017). Inclusion criterion was peer‐reviewed publications on clinical studies reporting original data. This study followed the Preferred Reporting Items for Systematic Review and Meta‐Analyses of individual participant data 2015 guidelines. Data were provided for 4 cohorts in 3 countries (151 participants with ulcerative colitis, 159 with Crohn's disease, and 227 control patients). Using aPWV, cohort‐specific z scores were calculated after loge‐transform and combined in meta‐analysis to form pooled effects using a random‐effects model. Compared with controls, aPWV was increased in patients with Crohn's disease (mean difference 0.78 z score; 95% confidence interval, 0.56–1.00 z score [P<0.001]) and ulcerative colitis (mean difference 0.75 z score; 95% confidence interval, 0.52–0.97 z score [P<0.001]). In an outlier‐robust multivariate linear regression model adjusted for prespecified confounders, aPWV was associated with disease duration (years, β=0.05 z score; 95% confidence interval, 0.02–0.08 z score [P<0.001]) and white blood cell count (billion cells/L, β=0.07 z score; 95% confidence interval, 0.02–0.11 z score [P=0.002]) but not with markers of acute inflammation (C‐reactive protein and erythrocyte sedimentation rate), cardiovascular risk factors, and therapy.ConclusionsThe increased aPWV reported in patients with inflammatory bowel disease is associated with inflammation.Clinical Trial Registration URL: http://www.crd.york.ac.uk. Unique identifier: PROSPERO 2016: CRD42016053070.

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“…Cyanotic patients with congenital heart diseases are often characterized by increased arterial stiffness in comparison with healthy population 2 . There is a direct relationship between aortic stiffness and left ventricular systolic and diastolic dysfunction in patients with inflammatory bowel disease 3 . Eradication of hepatitis C virus infection causes a significant decline in liver stiffness -particularly in patients with high baseline level of inflammation or patients who received direct-acting antiviral agents 4 , 5 .…”

Section: Introductionmentioning

confidence: 99%

Assessment of nanoindentation in stiffness measurement of soft biomaterials: kidney, liver, spleen and uterus

Gotthardt

Gollasch

2020

Sci Rep

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Nanoindentation technology with high spatial resolution and force sensitivity is widely used to measure the mechanical properties of hard biomaterials and tissues. However, its reliability to analyze soft biomaterials and organs has not been tested. Here, we evaluated the utility of nanoindentation to measure the passive mechanical properties of soft biological specimen. Kidney, liver, spleen and uterus samples were harvested from C57BL/6 N mice. We assessed test–retest repeatability in biological specimen and hydrogel controls using Bland–Altman diagrams, intraclass correlation coefficients (ICCs) and the within-subject coefficients of variation (COVs). The results were calculated using Hertzian, JKR and Oliver & Pharr models. Similar to hydrogels, Bland–Altman plots of all biological specimen showed good reliability in stiffness test and retest examinations. In gels, ICCs were larger than 0.8 and COVs were smaller than 15% in all three models. In kidney, liver, spleen and uterus, ICCs were consistently larger than 0.8 only in the Hertzian model but not in the JKR and Oliver & Pharr models. Similarly, COVs were consistently smaller than 15% in kidney, liver, spleen and uterus only in the Hertzian model but not in the other models. We conclude that nanoindentation technology is feasible in detecting the stiffness of kidney, liver, spleen and uterus. The Hertzian model is the preferred method to provide reliable results on ex vivo organ stiffness of the biological specimen under study.

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Association between aortic stiffness and left ventricular function in inflammatory bowel disease

Abstract: (Cardiol J 2016; 23, 2: 202-210)

Cited by 20 publications

References 30 publications

Inflammation and ventricular-vascular coupling in hypertensive patients with metabolic syndrome

Inflammation and ventricular-vascular coupling in hypertensive patients with metabolic syndrome

Inflammation and Aortic Stiffness: An Individual Participant Data Meta‐Analysis in Patients With Inflammatory Bowel Disease

Assessment of nanoindentation in stiffness measurement of soft biomaterials: kidney, liver, spleen and uterus

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