Association between aortic telomere length and cardiac post-transplant allograft function

Dlouhá, Dana; Vymetalova, Jevgenija; Hubacek, Jaroslav A.; Lánská, Věra; Málek, I

doi:10.1016/j.ijcard.2019.05.006

Cited by 2 publications

(3 citation statements)

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“…DSA binding to the allograft causes myocardial injury and allograft dysfunction predominantly through immune complex activation of the classical pathway of the complement cascade and thus is a significant risk for allograft failure, CAV, and poor survival [ 31 ]. We previously reported a relationship between shorter aortic telomere length and the development of CAV in heart transplant patients [ 23 ]. Recently, a higher risk of AMR development was also observed in patients undergoing OHT following mechanical circulatory support [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…Patients with chronic irreversible renal failure were contraindicated for orthotopic heart transplantation (OHT). Aortic biopsies of patients undergoing OHT were collected from January 2005 to December 2015 at the Institute for Clinical and Experimental Medicine in Prague as we described previously [ 22 , 23 ]. Briefly, aortic samples from 383 heart recipients (age 50.7 ± 11.9 years) and paired corresponding donors (age 38.7 ± 12.0 years) were obtained during OHT.…”

Section: Methodsmentioning

confidence: 99%

“…Analyses were performed with JMP 10 statistical software. ArTL values were available in 94.5% of all samples [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

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Posttransplant Complications and Genetic Loci Involved in Telomere Maintenance in Heart Transplant Patients

Dlouhá

Vymetalova

Novakova

et al. 2022

Genes

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Reaching critically short telomeres induces cellular senescence and ultimately cell death. Cellular senescence contributes to the loss of tissue function. We aimed to determine the association between variants within genes involved in telomere length maintenance, posttransplant events, and aortic telomere length in heart transplant patients. DNA was isolated from paired aortic samples of 383 heart recipients (age 50.7 ± 11.9 years) and corresponding donors (age 38.7 ± 12.0 years). Variants within the TERC (rs12696304), TERF2IP (rs3784929 and rs8053257), and OBCF1 (rs4387287) genes were genotyped, and telomere length was measured using qPCR. We identified similar frequencies of genotypes in heart donors and recipients. Antibody-mediated rejection (AMR) was more common (p < 0.05) in carriers of at least one G allele within the TERF2IP locus (rs3784929). Chronic graft dysfunction (CGD) was associated with the TERC (rs12696304) GG donor genotype (p = 0.05). The genetic risk score did not determine posttransplant complication risk prediction. No associations between the analyzed polymorphisms and telomere length were detected in either donor or recipient DNA. In conclusion, possible associations between donor TERF2IP (rs3784929) and AMR and between TERC (rs12696304) and CGD were found. SNPs within the examined genes were not associated with telomere length in transplanted patients.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%