Association between APOE polymorphisms and mesial temporal lobe epilepsy with hippocampal sclerosis

Abstract

To evaluate the hypothetical link between apolipoprotein E (APOE) polymorphisms and mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) and whether presence of APOE epsilon4 allele shortens the latent period between febrile seizures and epilepsy. A further interest is whether presence of APOE epsilon4 allele has an impact on severity of the disease. Forty-seven patients with MTLE-HS were compared with 62 controls. APOE polymorphisms were determined from lymphocytes by standard methods. Eight patients (17%) and 10 controls (16.1%) were demonstrated to have one APOE epsilon4 allele. There was not any statistically significant difference in APOE epsilon4 frequency between patients and controls (P > 0.05). There was not any difference statistically according to onset age of epilepsy and the presence of APOE epsilon4 allele within patient group. APOE epsilon4 polymorphisms did not influence the severity of epilepsy. APOE epsilon4 polymorphisms had no impact on outcome after surgery. Patients with bilateral memory deficits, bilateral hippocampal atrophy and with bilateral epileptiform interictal EEG transients, were independently compared with patients having unilateral features and there were not any statistically significant differences. This study has found no association between APOE epsilon4 polymorphisms and presentation of MTLE-HS in a group of Turkish patients.

Correlation between tumor-related seizures and molecular genetic profile in 103 Chinese patients with low-grade gliomas: A preliminary study

“…A few inherited syndromes for focal seizures have been reported [23,24], and an increasing number of susceptibility candidate genes have been brought forward for focal seizures during recent years [25]. Particularly, the apolipoprotein E (ApoE) was shown as a susceptibility candidate gene for temporal lobe epilepsy located on 19q13 by several studies [26,27]. To sum up, we assume that some of the susceptibility candidate genes associated with focal seizures may contribute to tumor-related seizures also in patients with…”

Association of refractory complex partial seizures with a polymorphism of ApoE genotype

“…It has been reported that apolipoprotein E polymorphism is not associated with the development of major seizure disorders including temporal lobe epilepsy [23][24][25]. Moreover, the inheritance of the ApoE ε4 allele is associated with increased risk of late posttraumatic seizures [26] and with earlier onset of temporal lobe epilepsy [27].…”

Biomarkers to Predict Alcohol Withdrawal Seizures - A Review of Current Literature

“…Regarding epileptic seizures, it has been observed that ApoE polymorphism is not associated with the development of major seizure disorders including temporal lobe epilepsy [51][52][53]. Nevertheless, studies reported an earlier onset of chronic temporal lobe epilepsy [54] as well as increased risk of late posttraumatic seizures [55] in patients carrying the ApoE4 genotype.…”