Association Between Arterial Carbon Dioxide Tension and Outcome in Patients Admitted to the Intensive Care Unit After Coronary Artery Bypass Surgery

Choi, Jeong-Hyun; Lee, E. H.; Jang, Myung-Soo; Jeong, Dae-Hee; Kim, M. K.

doi:10.1097/01.sa.0000521733.95008.78

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“…In other clinical settings, and in contrast with the results of the present study, Choi et al, in a retrospective cohort study that included 1,011 patients who entered the intensive care unit after cardiac surgery found that only the combined exposure to hypocapnia and hypercapnia within 24 hours after cardiac surgery was independently associated with a higher risk of mortality at 30 days and late extubation. Exposure to hypocapnia or hypercapnia alone was not associated with the patient's outcome (13) .…”

Section: Wwwmedigraphicorgmxmentioning

confidence: 82%

“…Previous experimental studies have shown inconsistent results regarding the effects of the partial pressure of arterial carbon dioxide (PaCO 2 ) on the prognosis of patients undergoing surgery in other clinical settings. Although most studies have shown that hypercapnia increases myocardial blood flow above metabolic demands, the assessment of the effects of hypocapnia has yielded variable results (10)(11)(12)(13)(14)(15)(16) .…”

Section: Introductionmentioning

confidence: 99%

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Impacto de los valores de bióxido de carbono post-pinzamiento aórtico sobre la morbimortalidad postoperatoria en pacientes pediátricos sometidos a cirugía cardíaca

García-López¹,

Guedes-Nicolá²,

Soto-Dávila³

et al. 2022

Revista Mexicana De Anestesiología

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Inducing hypocapnia is a common practice during pediatric general anesthesia, even though it has not shown clear benefits. Objective: To compare the impact of carbon dioxide values after aortic impingement (< 32.7 vs ≥ 32.7 mmHg) on postoperative morbimortality among pediatric patients undergoing cardiac surgery. Material and methods: A case-control study included 90 pediatric patients undergoing cardiac surgery with cardiopulmonary bypass. The study cases consisted of 45 patients who died within 30 days of the postoperative period. Cases and controls were individually matched (1:1 ratio). Descriptive and inferential statistics (Mann-Whitney's U, Student's t and χ 2 tests) were used to analyze the results. A p < 0.05 was considered significant. A univariate analysis was also carried out. The strength of association between morbimortality and carbon dioxide values after aortic impingement was determined using the odds ratio. The data were processed using SPSS v-24.0. Results: The group with carbon dioxide values of < 32.7 mmHg after aortic impingement was associated with greater morbidity (OR 24.75;) and mortality (OR 22.47;.17) at 30 days. Conclusion: Pediatric patients undergoing cardiac surgery with carbon dioxide values of < 32.7 mmHg after aortic impingement showed higher postoperative morbimortality than those with carbon dioxide values of ≥ 32.7 mmHg. RESUMEN. Introducción:La hipocapnia es una práctica común durante la anestesia general pediátrica; sin embargo, a lo largo del tiempo no ha mostrado beneficios bien definidos. Objetivo: Comparar el impacto del bióxido de carbono post-pinzamiento aórtico (< 32.7 vs ≥ 32.7 mmHg) sobre la morbimortalidad postoperatoria en los pacientes pediátricos sometidos a cirugía cardíaca. Material y métodos: Se realizó un estudio de casos y controles que incluyó 90 pacientes pediátricos sometidos a cirugía cardíaca con derivación cardiopulmonar. Se consideraron casos 45 pacientes que fallecieron dentro de los 30 días del postoperatorio. Los controles fueron pareados en relación 1:1. Para su análisis se realizó estadística descriptiva e inferencial con U de Mann-Whitney, t de Student y χ 2 según fue el caso. Una p < 0.05 fue significativa. Se realizó un análisis univariado. La fuerza de asociación entre la morbimortalidad y los valores de bióxido de carbono post-pinzamiento aórtico se obtuvo mediante el odds ratio. Los datos fueron procesados mediante SPSS v-24.0. Resultados: El grupo con valores de bióxido de carbono post-pinzamiento aórtico < 32.7 mmHg se asoció con una mayor morbilidad a los 30 días

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Section: Wwwmedigraphicorgmxmentioning

confidence: 82%