Association Between Arterial Stiffness and New-Onset Heart Failure: The Kailuan Study

Abstract

BACKGROUND: Arterial stiffness (AS) was associated with heart failure (HF) in previous studies based on specific populations with small samples and the effects of age and blood pressure on AS were not taken into account. Whether AS was independently associated with new-onset HF in community dwellers has not been fully investigated to date. METHODS: Individuals who participated in health evaluations and underwent synchronized brachial-ankle pulse wave velocity (baPWV) screening in 2010 to 2019 were included. They were free of HF and atrial fibrillation at baseline. The participants were allocated to 3 groups according to their baPWV values. Normal AS was defined as baPWV <1400 cm/s, borderline AS was defined as 1400≤baPWV<1800 cm/s, and elevated AS was defined as baPWV ≥1800 cm/s. Cox proportional hazard regression was used to calculate hazard ratios with 95% CIs of new-onset HF across different AS groups. RESULTS: A total of 40 064 participants were enrolled with a mean age of 48.81±12.67 years. During a mean 5.53 years of follow-up, 411 participants developed HF. Compared with the normal AS group, the hazard ratio (95% CI) for incident HF was 1.97 (1.36–2.86) for the borderline AS group and 2.24 (1.49–3.38) for the elevated AS group in the multivariable-adjusted model. For each 1 SD (359 cm/s) increase in baPWV, the hazard ratio (95% CI) for new-onset HF was 1.10 (1.02–1.20). CONCLUSIONS: AS was positively associated with a higher risk of new-onset HF independently of traditional risk factors, with a dose-responsive effect.

Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence

“…Increases in large elastic artery stiffness (i.e., increased aortic PWV and intrinsic mechanical wall stiffness) with aging is a major independent predictor of age‐associated clinical CVD (Vasan et al., 2022 ), impaired glucose tolerance (Zheng et al., 2023 ), kidney dysfunction (Ford et al., 2010 ), cognitive impairment (Thorin‐Trescases et al., 2018 ), and diabetic retinopathy (An et al., 2021 ). Fisetin supplementation reduced arterial stiffness (aortic PWV) in old wild‐type mice by reducing aortic intrinsic mechanical wall stiffness.…”

Association of Abnormal Lung Function and Its Subtypes With Arterial Stiffness: A Longitudinal Cohort Study

“… 24 Longitudinal cohort studies based on the general Chinese population have shown that borderline arterial stiffness (1400 ≤baPWV <1800 cm/s) is an independent risk factor for the onset of heart failure. 25 Another study showed that baPWV >1400 cm/s was significantly associated with coronary heart disease and stroke, 26 suggesting that baPWV at >1400 cm/s can reflect CVD risk at an earlier stage. Therefore, the present study defined elevated arterial stiffness as baPWV ≥1400 cm/s.…”

Assessment of Subclinical Atherosclerosis in Asymptomatic People In Vivo: Measurements Suitable for Biomarker and Mendelian Randomization Studies

“…Moreover, recent data indicate that pulse wave velocity may be an important predictor of future heart failure. 141 Therefore, as for abnormally high ABI, aortic stiffness may not reflect the presence of subclinical atherosclerosis, and any association with cardiovascular events or CVD may result from other mechanisms. A variety of other tests such as retinal vessel caliber and skin autofluorescence also cannot be used to infer the presence of subclinical atherosclerosis.…”