Association Between Arterial Stiffness and Atherosclerosis

Popele, Nicole M. van; Grobbee, Diederick E.; Bots, Michiel L.; Asmar, Roland; Topouchian, Jirar; Reneman, Robert S.; Hoeks, Arnold P.G.; Kuip, Deidre A. M. van der; Hofman, Albert; Witteman, Jacqueline C. M.

doi:10.1161/01.str.32.2.454

Cited by 1,013 publications

(765 citation statements)

References 36 publications

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“…[2][3][4] In population-based studies, aortic stiffness is an independent predictor of cardiovascular outcomes after adjustment for traditional cardiovascular risk factors. [4][5][6][7] Arterial stiffness has been shown to predict coronary artery disease [8][9][10][11] and cardiovascular mortality in patients with essential hypertension, 12 end-stage renal disease 13,14 and impaired glucose tolerance and diabetes mellitus (DM). 15 Although there are many measures to quantify stiffness, none of them is a gold standard, but approximations.…”

Section: Introductionmentioning

confidence: 99%

Relationship between blood pressure parameters and pulse wave velocity in normotensive and hypertensive subjects: invasive study

et al. 2006

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Blood pressure (BP) is one of the most important contributing factors to pulse wave velocity (PWV), a classic measure of arterial stiffness. Although there have been many non-invasive studies to show the relation between arterial stiffness and BP, the results are controversial. The aim of this study is to evaluate the role of BP as an influencing factor on PWV using invasive method. We observed 174 normotensive and untreated hypertensive subjects using coronary angiography. Arterial stiffness was assessed through aorto-femoral PWV by foot-to-foot velocity method using fluid-filled system. And BP was measured by pressure wave at the right common femoral artery. From univariate analysis, age, diabetes mellitus (DM), hypertension, waist, waist-to-hip ratio, total cholesterol-tohigh-density lipoprotein cholesterol ratio, systolic BP (SBP), pulse pressure (PP) and mean arterial pressure (MAP) showed significant association with PWV. To avoid multiple colinearity among SBP, PP and MAP, we performed multiple regression analysis predicting PWV thrice. Age, DM and each BP were significantly and consistently correlated to PWV. In the first and third modules, compared to age, SBP and MAP were less strong predictors, respectively. However, PP was the stronger predictor than age and DM in the second module. Lastly, we simultaneously forced MAP and PP with other variables in the fourth multivariate analysis. Age, DM and PP remained significantly correlated with PWV, but the significance of MAP was lost. This is the first invasive study to suggest that PP has the strongest correlation with PWV among a variety of BP parameters.

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Section: Introductionmentioning

confidence: 99%

Relationship between blood pressure parameters and pulse wave velocity in normotensive and hypertensive subjects: invasive study

et al. 2006

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“…3 In recent years, researchers have used pulse wave analysis to show that arterial stiffness is associated with CVD, specifically atherosclerotic burden. 4 Arterial compliance decreases as the severity of atherosclerosis increases. 4 Importantly, changes in the compliance of small and large arteries precede (by years) the presence of plaques characteristic of atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

“…4 Arterial compliance decreases as the severity of atherosclerosis increases. 4 Importantly, changes in the compliance of small and large arteries precede (by years) the presence of plaques characteristic of atherosclerosis. 5 These changes are important early predictors of the risk of CVD and related events.…”

Section: Introductionmentioning

confidence: 99%

The effects of functional electrical stimulation leg cycle ergometry training on arterial compliance in individuals with spinal cord injury

et al. 2008

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Study design: A prospective intervention of functional electrical stimulation leg cycle ergometry (FES-LCE) of four women with spinal cord injury (SCI). Objective: To evaluate the effect of FES-LCE training on arterial compliance in individuals with chronic SCI of traumatic origin. Setting: Tertiary rehabilitation center in Canada. Methods: Large and small artery compliance were measured at the radial artery before and after a 3-month training program using FES-LCE. Results: There was no significant change in large artery compliance after FES-LCE (16.0 ± 4.2 to 16.8±6.1 ml mm Hg À1 Â 10, P ¼ NS). There was a marked (63%) increase in small artery compliance after the FES training program (4.2 ± 1.8 to 6.9 ± 3.2 ml mm Hg À1 Â 100, Po0.05).Conclusion: It appears that FES-LCE is effective in improving small artery compliance in females with SCI.

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“…[4][5][6] During the recent years, technological progress has enabled reliable measurement of vascular compliance, a means of assessing the early stages of vascular disease. One such technique, arterial pulse-wave contour analysis, involves quantifying the amount of arterial stiffening and can be regarded as a valid marker of generalized atherosclerosis 7,8, as well as a predictor of cardiovascular mortality. [9][10][11] Estimation of vascular compliance may serve as a surrogate end point for morbid risk and treatment benefit.…”

Section: Introductionmentioning

confidence: 99%

The effect of a rapid weight loss induced by laparoscopic adjustable gastric banding on arterial stiffness, metabolic and inflammatory parameters in patients with morbid obesity

et al. 2006

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Objective: To determine the effect of drastic weight loss on arterial compliance, inflammatory and metabolic parameters in patients with morbid obesity with and without cardiovascular risk factors who underwent laparoscopic adjustable gastric banding (LAGB). Design: Open prospective study, morbidly obese subjects divided into low-and high-risk group were evaluated before and 4 months after LAGB. Subjects: Forty-one Caucasian subjects aged between 16 and 55 years, with morbid (grade 3) obesity (20 low-risk and 21 highrisk subjects) who underwent LAGB and completed a 16-week follow-up. Measurments: Patients were evaluated at baseline and 4 months after LAGB for body mass index (BMI), arterial blood pressure (BP), metabolic factors including lipid profile, HbA1C, insulin, C-peptide, fibrinogen, hs-C reactive protein (CRP) and Homeostasis model assessment-insulin resistance (HOMA-IR). Arterial elasticity of large and small arteries was evaluated using pulse-wave contour analysis method (HDI CR 2000, Eagan, Minnesota) at baseline and after 4 months. Results: Body mass index reduction induced by LABG, from 43.5575.11 to 35.1074.87 in low-risk patients and from 42.9073.22 to 35.0073.24 in high-risk patients, significantly improved small artery elasticity (SAE) from 6.3072.74 to 7.2571.85, in morbidly obese patients with multiple cardiovascular risk factors (high-risk group). Improvement in SAE was accompanied by improvement of arterial BP, glucose and lipid metabolism, and reduction of CRP values. Conclusion: Although dramatic weight reduction induced by surgical intervention was associated with similar changes in body weight and significant improvement of metabolic and inflammatory parameters in two groups of obese patients, SAE improved only in high-risk patients.

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Association Between Arterial Stiffness and Atherosclerosis

Abstract: This population-based study shows that arterial stiffness is strongly associated with atherosclerosis at various sites in the vascular tree.

Cited by 1,013 publications

References 36 publications

Relationship between blood pressure parameters and pulse wave velocity in normotensive and hypertensive subjects: invasive study

Relationship between blood pressure parameters and pulse wave velocity in normotensive and hypertensive subjects: invasive study

The effects of functional electrical stimulation leg cycle ergometry training on arterial compliance in individuals with spinal cord injury

The effect of a rapid weight loss induced by laparoscopic adjustable gastric banding on arterial stiffness, metabolic and inflammatory parameters in patients with morbid obesity

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