Association between Asthma and Autism Spectrum Disorder: A Meta-Analysis

Zheng, Zhen; Zhang, Li; Zhu, Tingting; Huang, Jingsheng; Qu, Yi; Mu, Dezhi

doi:10.1371/journal.pone.0156662

Cited by 36 publications

(45 citation statements)

References 31 publications

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“…the presence of more than 1 chronic physical condition) in people with mental illness. Nonetheless, some recent large scale multi-national studies have demonstrated that people with SMI 41,48 , CMDs 49,50 and SUDs 18,51 are at greatly increased risk of physical multimorbidity, right from illness onset. 52 Multimorbidity occurs from a relatively young age in people with mental illness 41,52 , and greatly increases personal and economic burden associated with chronic conditions, while also reducing life expectancy.…”

Section: Post-traumatic Stress Disordermentioning

confidence: 99%

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The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness

Firth

Siddiqi

Koyanagi

et al. 2019

The Lancet Psychiatry

1,040

1,093

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Executive SummaryThe poor physical health of people with mental illness is a multi-faceted, transdiagnostic, and global problem. Physical health disparities are observed across the entire spectrum of mental illnesses, in low, middle-and high-income countries. This stems from both a heightened risk of physical diseases in people with mental illness, along with their reduced access to adequate healthcare. The high rates of physical comorbidities (and typically-poor clinical management of this) drastically reduces life expectancy, and also increases the personal, social and economic burden of illness across the lifespan.This Commission has brought together an international team of researchers, clinicians, and key stakeholders from various backgrounds and professionally / personally-relevant experience, in order to summarize advances in understanding on this topic, and present clear directions for health promotion, clinical care and future research. The breadth and multifactorial nature of physical health disparities across the range of mental health diagnoses poses an almost limitless number of potential considerations. Therefore, rather than attempting to cover all of the different possible combinations of physical-mental comorbidities individually, the aim of this Commission was to: (i) establish highlypertinent aspects of physical health-related morbidity and mortality which apply transdiagnostically, (ii) highlight the common modifiable factors driving these disparities, (iii) present actions and initiatives for health policy and clinical services to address these issues, and (iv) identify promising areas for future research towards discovering novel solutions. This was addressed across 5 different Parts of the Commission: Parts 1 and 2 determined the scope, priorities and key targets for physical health improvement across multiple mental illnesses. Parts 3, 4 and 5 discussed emerging strategies and produced recommendations for improving physical health outcomes in people with mental illness. Leaders and contributors for each Part are shown in the Appendix (pg.1) . Part 1: 'Its more than premature mortality'Part 1 identified almost 100 systematic reviews/meta-analyses examining the prevalence of physical comorbidities in mental illness. Around 70% of the meta-research focused on cardiometabolic diseases; consistently reporting that mental illnesses were associated with 1.4-to 2-fold increased risk for obesity, diabetes and cardiovascular diseases compared to the general population. Although mostly studied in 'severe mental illness' ('SMI', and particularly psychotic disorders), the prevalence of cardiometabolic diseases was similarly elevated across a broad range of other diagnoses, including substance use disorders (SUDs), and 'common mental disorders' ('CMDs', such as depression and anxiety). Part 2: Key modifiable factors in health behaviours and health servicesPart 2 built on the findings of Part 1 with a hierarchal evidence synthesis of modifiable risk factors for physical diseases in mental illness. The bu...

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Section: Post-traumatic Stress Disordermentioning

confidence: 99%

“…16,17 Risk of asthma is also increased in autism. 18 In bulimia, there is a marked increase in risk of diabetes (OR 3.45) and in anorexia, the risk is significantly decreased (OR 0.71). 19 The risk of osteoporosis is increased over twelve-fold in the latter.…”

Section: Other Mental Disordersmentioning

confidence: 99%

The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness

Firth

Siddiqi

Koyanagi

et al. 2019

The Lancet Psychiatry

1,040

1,093

View full text Add to dashboard Cite

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“…ASD is a complex and heterogeneous disorder. Due to the social, cognitive, and behavioral limitations associated with ASD, individuals with ASD are found to be more likely to suffer from physical conditions such as obesity and gastrointestinal disorders [Bresnahan et al, ; Zheng et al, ], but not other medical conditions such as asthma and allergies [Lyall, Van de Water, Ashwood, & Hertz‐Picciotto, ; Zheng et al, ]. Furthermore, ASD is also often found to be comorbid with mental health disorders such as schizophrenia and attention deficit/hyperactivity disorder [Antshel, Zhang‐James, & Faraone, ; Panagiotidi, Overton, & Stafford, ].…”

Section: Introductionmentioning

confidence: 99%

Association between schizophrenia and autism spectrum disorder: A systematic review and meta‐analysis

2018

Self Cite

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Schizophrenia and autism spectrum disorder (ASD) are significant public health problems. Scientists have recently explored the association between schizophrenia and ASD, but the findings are inconsistent. Thus, we conducted a systematic review and meta-analysis of epidemiological studies to examine the association between schizophrenia and ASD. PubMed, Embase, and the Cochrane Library were used for literature searches to identify eligible studies published in English before October 2, 2017. Relevant studies estimating the association between schizophrenia and ASD were included. The meta-analysis of the prevalence of schizophrenia in individuals with ASD encompassed 1,950,113 participants and 14,945 individuals with ASD. A random-effects model was chosen to synthesize the effect sizes of individual studies. The prevalence of schizophrenia was significantly higher in individuals with ASD than in controls (odds ratio = 3.55, 95% confidence interval: 2.08-6.05, P < .001). Both sensitivity analysis and publication bias testing revealed that the findings were robust. The systematic review of the prevalence of ASD in individuals with schizophrenia encompassed 930 participants. The prevalence of ASD in individuals with schizophrenia ranged from 3.4 to 52%. The systematic review and meta-analysis showed a significant association between schizophrenia and ASD.Lay Summary: This systematic review and meta-analysis explored the association between schizophrenia and ASD. We found that the prevalence of schizophrenia was significantly higher in individuals with ASD than in controls and the prevalence of ASD in individuals with schizophrenia ranged from 3.4 to 52%. A comprehensive estimation of schizophrenia and ASD has important implications for the diagnosis, treatment, prognosis, and development of a fundamental understanding of these disorders.

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“…The overall prevalence of ASD is 1 in 68 children 11 . Additionally, ASD is co-morbid with mental health disorders such as anxiety disorder and attention deficit/hyperactivity disorder but not with medical condition such as asthma and allergy 12–15 . Since ASD is a serious public health problem, scientists have attempted to identify biomarkers to achieve an earlier diagnosis and enable earlier treatment.…”

Section: Introductionmentioning

confidence: 99%

Association among obesity, overweight and autism spectrum disorder: a systematic review and meta-analysis

Zheng

Zhang

et al. 2017

Sci Rep

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Obesity, overweight and autism spectrum disorder (ASD) remain serious public health problems. Although lots of studies have recently explored the association among obesity, overweight and ASD, the findings are inconsistent. Thus, we conducted a meta-analysis of epidemiological studies to examine the association among obesity, overweight and ASD. PubMed, Embase, and the Cochrane Library were used for literature searches to identify eligible studies published in English before November 15, 2016. Relevant studies estimating the association among obesity, overweight and ASD were included. Fifteen studies encompassing 49,937,078 participants and 1,045,538 individuals with ASD were included in this study. A random effects model was chosen to synthesize the effect sizes of individual studies. The prevalence of obesity was significantly higher in individuals with ASD than in controls (OR = 1.84, 95% confidence interval [CI]: 1.37–2.48, P < 0.001). However, the prevalence of overweight in individuals with ASD was not significantly different from that in controls (OR = 1.07, 95% CI: 0.83–1.38, P = 0.62). Both sensitivity analysis and publication bias testing revealed that the findings were robust. The meta-analysis showed a significant association between obesity and ASD. However, no significant association was identified between overweight and ASD.

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Association between Asthma and Autism Spectrum Disorder: A Meta-Analysis

Cited by 36 publications

References 31 publications

The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness

The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness

Association between schizophrenia and autism spectrum disorder: A systematic review and meta‐analysis

Association among obesity, overweight and autism spectrum disorder: a systematic review and meta-analysis

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