Association between atherosclerosis and handgrip strength in non‐hypertensive populations in India and Japan

Abstract

AimAlthough several risk factors contribute to the development of sarcopenia, whether preclinical atherosclerosis contributes to the risk of sarcopenia is not established. The present cross‐sectional study aimed to investigate if there is an association between preclinical atherosclerosis and muscle strength among two ethnic populations.MethodsParticipants included individuals aged ≥40 years and enrolled in the third follow‐up examination of the Andhra Pradesh Children and Parents Study, India, and in the baseline assessments of the Nagasaki Islands Study, Japan. Preclinical atherosclerosis was evaluated by carotid intima‐media thickness, brachial‐ankle pulse wave velocity, cardio‐ankle vascular index. The association of carotid intima‐media thickness and pulse wave velocity/cardio‐ankle vascular index with handgrip strength (HGS) was analyzed separately in the sexes and for hypertensive status from the two cohorts using a multivariable linear regression model.ResultsData on a total of 1501 participants in India and 3136 participants in Japan were analyzed. Carotid intima‐media thickness was negatively associated with HGS in non‐hypertensive Indian men (B coefficient = −5.38, P = 0.036). Arterial stiffness was also associated with HGS in non‐hypertensive Indian men (B = −0.97, P = 0.001), but not in hypertensive Indian men. Same as Indian men, we found the significant associations between arterial stiffness and HGS in non‐hypertensive women in both India and Japan (B = −0.44, P = 0.020, B = −0.63, P = 0.016, respectively), but not in hypertensive women.ConclusionsThe negative association between preclinical atherosclerosis and HGS was dominantly found in non‐hypertensive participants. Geriatr Gerontol Int 2018; 18: 1071–1078.

Sarcopenia is associated with blood pressure variability in older patients with type 2 diabetes: A cross‐sectional study of the KAMOGAWA‐DM cohort study

“…29 In fact, the brachial-ankle pulse wave velocity of patients with sarcopenia was higher than that of patients without sarcopenia among the patients without the history of cardiovascular disease (2101.7 [SD 307.8] cm/s vs 1874.9 [343.4] cm/s, P = 0.021 by the Mann-Whitney U-test), which is the same as previous studies. 17,30 Taken together, sarcopenia is associated with blood pressure variability.…”

A cross-sectional study of the relationships between different components of sarcopenia and brachial ankle pulse wave velocity in community-dwelling elderly

“…HS are proved to be associated with all-cause mortality and cardiovascular mortality [18,19]. Hirotomo Yamanashi et al reported arterial stiffness was associated with HS in nonhypertensive populations, but not in hypertensive populations [20]. Whereas, a long-term study result showed that there was no relation between HS and arterial stiffness [21].…”

A cross-sectional study of the relationships between different components of sarcopenia and brachial ankle pulse wave velocity in community-dwelling elderly

“…HS are proved to be associated with all-cause mortality and cardiovascular mortality [18,19]. Hirotomo Yamanashi et al reported arterial stiffness was associated with HS in non-hypertensive populations, but not in hypertensive populations [20]. Whereas, a long-term study result showed that there was no relation between HS and arterial stiffness [21].…”