Association Between Atopic Dermatitis and Autism Spectrum Disorder: A Systematic Review and Meta-analysis

Tsai, Tsung Yu; Chao, Yuan Chen; Hsieh, Cheng Yu; Huang, Yu Chen

doi:10.2340/00015555-3501

Cited by 15 publications

(7 citation statements)

References 11 publications

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“…A previous meta-analysis reported a bidirectional relationship between AD and ASD [72]. A positive association was suggested based on the comparisons of ASD prevalence between patients with AD and healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Associations of Atopic Dermatitis with Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

Cheng,

Lu,

Wang

et al. 2023

Dermatology

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Background: Atopic dermatitis (AD) shares similarities with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) regarding pathogenesis involving neuroinflammation and genetics. Nevertheless, evidence on the associations of AD with ADHD and/or ASD is inconclusive. This study aimed to systematically examine the existing evidence on the associations between AD, ADHD, and ASD. Methods: The Meta-Analysis of Observational Studies in Epidemiology guideline was followed. We searched MEDLINE, Embase, Cochrane Library, and Web of Science databases from their respective inceptions to March 4, 2022. Observational studies providing adjusted estimates and/or prevalences for ADHD and ASD in patients with AD were enrolled. A random-effects model meta-analysis was conducted to calculate pooled odds ratios (ORs) and confidence intervals (CIs). Subgroup analyses according to AD severity, age, geographic location, and study design were performed. Results: Overall, a total of 24 studies with 71,373,639 subjects were enrolled. Our meta-analysis demonstrated significant associations of AD with ADHD (pooled OR: 1.28; 95% CI: 1.18–1.40) and ASD (pooled OR: 1.87; 95% CI: 1.30–2.68). Subgroup analyses revealed that the associations for ADHD were the most prominent in studies evaluating severe AD patients as well as in studies focusing on school-age children and adolescents. Among patients with AD, the pooled prevalence of ADHD was 6.6%, and the respective prevalence of ASD was 1.6%. Conclusion: The evidence to date suggests significant associations of AD with ADHD and ASD. Psychiatric consultation and an interdisciplinary approach would benefit patients with AD presented with behavioral symptoms suggestive of ADHD or ASD.

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Section: Discussionmentioning

confidence: 99%

Associations of Atopic Dermatitis with Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

Cheng,

Lu,

Wang

et al. 2023

Dermatology

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“…But these drugs risk side effects [45]. However, evidence suggests a pathogenic role of inflammation in the development of autism, evidenced by increased cytokine levels in both the circulation and the brain, altered distribution of both B and T cells in autistic individuals, and increased prevalence of autism in individuals with inflammatory skin disorders [46][47][48][49]. Interestingly, mothers with eczema/psoriasis increase the risk of autism for their kids (adjusted OR = 1.39, 95% CI: 1.00-1.95) [50], suggesting pathogenic role of inflammation in autism.…”

Section: Resultsmentioning

confidence: 99%

Alterations in Epidermal Biophysical Properties in Autistic Children

Wang¹,

Li²,

Wang³

et al. 2023

Skin Pharmacol Physiol

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Autism is a neurodevelopmental disorder. Individuals with autism can exhibit multiple neurological symptoms such as deficit in social communication, restricted interests and repetitive behaviors. Recent study showed that murine model of autism displays an increased transepidermal water loss (TEWL) and dry skin. But whether epidermal functions are also altered in children with autism is unknown. In the present study, TEWL, stratum corneum hydration and skin surface pH were compared between children with autism (N=56) and normal controls (N=48). Our results showed that children with autism exhibited lower stratum corneum hydration levels, higher TEWL and elevated skin surface pH in comparison to normal controls (p<0.0001 for all). These results demonstrate that children with autism exhibit epidermal dysfunction.

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“…This study, like Billeci's previous one, demonstrates a significant correlation between atopic dermatitis and ASD. Further research is needed on the possibility of a joint pathogenesis between atopic dermatitis and ASD (Tsai, 2020).…”

Section: Discussionmentioning

confidence: 99%

Health status of people with autism spectrum disorder

Koceski

Trajkovski²

2021

AIA

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Purpose The aim of this study is to determine what changes occur in the health status of people with autism spectrum disorder (ASD) compared to neurotypical controls. Design/methodology/approach The authors performed a comparative analysis of data collected from 72 subjects with ASD and 75 neurotypical controls aged 3–24 years using the Rochester Health Status Survey IV (RHSS-IV). A structured individual interview was conducted to compare the health status of subjects in Macedonia. Findings A majority of people with ASD take vitamins, supplements and use recommended drug therapies compared to the neurotypical population and experience a larger number of side effects (p = 0.000). Compared to people with neurotypical development, children with ASD have a higher prevalence of oral ulcers (31.9% vs 17.3%; p = 0.039), changes in neurological health status – epilepsy (19.4% vs 2.7%; p = 0.001) and ADD/ADHD (only persons with ASD-19.4%; p = 0.000); respiratory diseases – angina (30.5% vs 8%; p = 0.000), rhinitis and/or sinusitis (40.3% vs 17.3%; p = 0.02); changes in the gastrointestinal system – constipation (31.9% vs 10.6%; p = 0.02), intestinal inflammation (19.4% vs 8%; p = 0.043), permeable intestines (only persons with ASD – 13.9%; p = 0.000) and the presence of the fungus Candida albicans (19.4% vs 4%; p = 0.043); psychiatric disorders – sleep problems (only in people with ASD – 18%; p = 0.000) and tics (6.9% vs 2.6%; p = 0.25) and skin diseases – eczema/allergic skin rash (36.1% vs 18.7%; p = 0.02). Originality/value Many children with ASD have health problems. These findings support and complement the professional literature on their mutual causality.

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Association Between Atopic Dermatitis and Autism Spectrum Disorder: A Systematic Review and Meta-analysis

Abstract: Fig. 1. Study flow diagram. Selection of studies included in the present systematic review and meta-analysis.

Cited by 15 publications

References 11 publications

Associations of Atopic Dermatitis with Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

Associations of Atopic Dermatitis with Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

Alterations in Epidermal Biophysical Properties in Autistic Children

Health status of people with autism spectrum disorder

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