Association between attention deficit hyperactivity disorder and asthma: a systematic review and meta-analysis and a Swedish population-based study

Cortese, Samuele; Sun, Shihua; Zhang, Junhua; Sharma, Esha; Chang, Zheng; Kuja‐Halkola, Ralf; Almqvist, Catarina; Larsson, Henrik; Faraone, Stephen V.

doi:10.1016/s2215-0366(18)30224-4

Cited by 126 publications

(119 citation statements)

References 39 publications

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“…In ADHD, asthma and obesity are increased. 16,17 Risk of asthma is also increased in autism. 18 In bulimia, there is a marked increase in risk of diabetes (OR 3.45) and in anorexia, the risk is significantly decreased (OR 0.71).…”

Section: Other Mental Disordersmentioning

confidence: 99%

The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness

Firth

Siddiqi

Koyanagi

et al. 2019

The Lancet Psychiatry

1,037

1,093

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Executive SummaryThe poor physical health of people with mental illness is a multi-faceted, transdiagnostic, and global problem. Physical health disparities are observed across the entire spectrum of mental illnesses, in low, middle-and high-income countries. This stems from both a heightened risk of physical diseases in people with mental illness, along with their reduced access to adequate healthcare. The high rates of physical comorbidities (and typically-poor clinical management of this) drastically reduces life expectancy, and also increases the personal, social and economic burden of illness across the lifespan.This Commission has brought together an international team of researchers, clinicians, and key stakeholders from various backgrounds and professionally / personally-relevant experience, in order to summarize advances in understanding on this topic, and present clear directions for health promotion, clinical care and future research. The breadth and multifactorial nature of physical health disparities across the range of mental health diagnoses poses an almost limitless number of potential considerations. Therefore, rather than attempting to cover all of the different possible combinations of physical-mental comorbidities individually, the aim of this Commission was to: (i) establish highlypertinent aspects of physical health-related morbidity and mortality which apply transdiagnostically, (ii) highlight the common modifiable factors driving these disparities, (iii) present actions and initiatives for health policy and clinical services to address these issues, and (iv) identify promising areas for future research towards discovering novel solutions. This was addressed across 5 different Parts of the Commission: Parts 1 and 2 determined the scope, priorities and key targets for physical health improvement across multiple mental illnesses. Parts 3, 4 and 5 discussed emerging strategies and produced recommendations for improving physical health outcomes in people with mental illness. Leaders and contributors for each Part are shown in the Appendix (pg.1) . Part 1: 'Its more than premature mortality'Part 1 identified almost 100 systematic reviews/meta-analyses examining the prevalence of physical comorbidities in mental illness. Around 70% of the meta-research focused on cardiometabolic diseases; consistently reporting that mental illnesses were associated with 1.4-to 2-fold increased risk for obesity, diabetes and cardiovascular diseases compared to the general population. Although mostly studied in 'severe mental illness' ('SMI', and particularly psychotic disorders), the prevalence of cardiometabolic diseases was similarly elevated across a broad range of other diagnoses, including substance use disorders (SUDs), and 'common mental disorders' ('CMDs', such as depression and anxiety). Part 2: Key modifiable factors in health behaviours and health servicesPart 2 built on the findings of Part 1 with a hierarchal evidence synthesis of modifiable risk factors for physical diseases in mental illness. The bu...

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Section: Other Mental Disordersmentioning

confidence: 99%

The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness

Firth

Siddiqi

Koyanagi

et al. 2019

The Lancet Psychiatry

1,037

1,093

View full text Add to dashboard Cite

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“…Comorbidity with allergic and autoimmune disorders such as atopic eczema, allergic rhinitis and asthma is another factor that could increase the risk for ADHD and future research may lead to a better understanding of the mechanisms underlying the observed comorbidity [38,[42][43][44]. In a meta-analysis and a large-scale genome-wide association study (GWAS), associations between asthma and ADHD were found in both children and adults [45,46]. Also, patients with ADHD and asthma had similar brain region dysfunctions and higher levels of cytokines and IgE compared to healthy children, resulting in alterations to the regions in the brain associated with emotional and behavioural control [38,42,47].…”

Section: Inflammation and The Relationship With Adhdmentioning

confidence: 99%

Antioxidants as a Potential Target against Inflammation and Oxidative Stress in Attention-Deficit/Hyperactivity Disorder

et al. 2020

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Psychostimulants and non-psychostimulants are the medications prescribed for the treatment of attention-deficit/hyperactivity disorder (ADHD). However, several adverse results have been linked with an increased risk of substance use and side effects. The pathophysiology of ADHD is not completely known, although it has been associated with an increase in inflammation and oxidative stress. This review presents an overview of findings following antioxidant treatment for ADHD and describes the potential amelioration of inflammation and oxidative stress using antioxidants that might have a future as multi-target adjuvant therapy in ADHD. The use of antioxidants against inflammation and oxidative conditions is an emerging field in the management of several neurodegenerative and neuropsychiatric disorders. Thus, antioxidants could be promising as an adjuvant ADHD therapy.

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“…For the years of parents going out and the grades of left-behind children, r was calculated by the same method, using two groups at both ends because they are continuous variables. We use Cohen's guidance to explain the effect size, where r is at least 0.10 = small, 0.30 = medium, and 0.50 = large (Cairns, Yap, Pilkington, & Jorm, 2014;Cohen, 1992).Because of the heterogeneity among the studies, we use the random effect model to analyse the data (Cortese et al, 2018). I 2 was used to assess heterogeneity while Egger test and funnel plots to assess publication bias (Egger, Davey Smith, Schneider, & Minder, 1997;Egger, Smith, & Phillips, 1997).…”

Section: Discussionmentioning

confidence: 99%

What Really Matters for Social Adaptation Among Left-Behind Children in China? A Systematic Review and Meta-Analysis

Zhang¹,

Fang²

2019

WJE

Self Cite

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Compared with non-left-behind children, left-behind children in China have lower social adaptation and theunderlying reasons deserve further study. This systematic review and meta-analysis included 29 studies publishedbetween 2006 and 2019. Protective factors of Left-behind children's social adaptation were resilience (r=0.574),self-efficacy (r=0.538), emotional intelligence (r=0.421), self-esteem (r=0.404), positive coping (r=0.471),attachment (r=0.354) and social support (r=0.338) while risky factors were loneliness (r=- 0.453) and socialanxiety(r=-0.360). Age, birthplace, father/mother migration and the frequency of parent-child communication alsohave a certain impact on their social adaptation, but the effect size is relatively small. This study can provide someenlightenment for intervention programs and policy adjustment. More empirical studies focusing on influencingfactors for social adaptation of left-behind children will be needed in the future.

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Association between attention deficit hyperactivity disorder and asthma: a systematic review and meta-analysis and a Swedish population-based study

Abstract: Swedish Research Council and Shire International GmbH.

Cited by 126 publications

References 39 publications

The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness

The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness

Antioxidants as a Potential Target against Inflammation and Oxidative Stress in Attention-Deficit/Hyperactivity Disorder

What Really Matters for Social Adaptation Among Left-Behind Children in China? A Systematic Review and Meta-Analysis

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