Association between biochemical hyperandrogenism
parameters and modified Ferriman-Gallwey score
in patients with hirsutism in Basrah (Southern Iraq)

Hussein, Rudha Naser; Hamdi, Khalil I.; Mansour, Abbas Ali

doi:10.5114/ada.2021.108907

Cited by 5 publications

(5 citation statements)

References 15 publications

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“…The cut-off of total Testosterone = ≤57.7 ng/dl. In group A, the total Testosterone was 79.42±17.40 and in the group, B was 79.90±15.39 8 . Total follicles in group A,=13.06±0.68 and in group B=13.33± 0.48, cut-off value = ≥12 and coinciding the study done by Wongwananuruk et al 15 .…”

Section: Resultsmentioning

confidence: 88%

“…2) Clinical or biochemical hyperandrogenism (Ferriman-Gallwey score ≥8 or Total testosterone ≥ 50ng/dL). 3) Polycystic ovaries on ultrasound ≥12 antral follicles measuring 2-9 mm in diameter or ovarian volume >10 mL in at least 1 ovary by trans-abdominal ultrasound 8 .…”

Section: Methodsmentioning

confidence: 99%

“…Friedewald's equation estimated very low-density lipoprotein (VLDL). 13 Clinical hyperandrogenism was evaluated by modified Ferriman-Gallwey (mFG) score which indicates terminal hairs on nine body areas; upper lip, chin, chest, upper back, lower back, upper abdomen, lower abdomen, arms and thigh, ≥8 is considered hirsutism 8 . All the variables were evaluated before and after three months.…”

Section: Methodsmentioning

confidence: 99%

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Outcomes of Pioglitazone and Metformin on Anthropometric, Metabolic and Endocrine variables in POS

Khan¹,

Arslaan²,

Pahore³

et al. 2023

PJMHS

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Aim: To evaluate the outcomes of Pioglita zone and Metformin on anthropometric, metabolic and endocrine variables in PCOS. Methods: This randomized controlled trial was executed at Pharmacology Department of Bahria University Medical and Dental College in collaboration with Mamji Hospital Karachi from September 2018 to March 2019. Eighty PCOS infertile patients as per Rotterdam 2003 criteria,aged 20-40 years were enrolled. They were divided into two groups of 40 patients each by using computer generated numbers. All patients had fasting insulin levels of >9 μU/mL, serum glucose levels ≥126 mg/dl and suffering from oligomenorrhoea or amenorrhoea. Group A received Tablet Pioglitazone 30 mg once daily and group B was given tablet Metformin 500 mg for three months along with lifestyle changes. Results: Sixty-one participants completed the study. Anthropometric variables included weight, BMI and W/H ratio. Metformin treated group reduced more weight and BMI as compared to Pioglitazone. Metabolic variables included glycaemic indices, lipid profile and hs-CRP estimation. Pioglitazone group improved glycaemic indices more compared to Metformin. Serum progesterone level was significantly increased in Pioglitazone group (5.20±1.18) than Metformin group. Pioglitazone produced more ovulation in comparison to Metformin. Hence it is proved that it is better option in those patients who are unable to tolerate Metformin and cannot continue treatment for infertility. Conclusion: Pioglitazone group produced highly significant increase in serum progesterone level indicating ovulation and improved insulin resistance than the metformin group. Keywords: Female infertility, ovulation induction, Metformin, Pioglitazone, polycystic ovarian syndrome

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Section: Resultsmentioning

confidence: 88%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Outcomes of Pioglitazone and Metformin on Anthropometric, Metabolic and Endocrine variables in POS

Khan¹,

Arslaan²,

Pahore³

et al. 2023

PJMHS

View full text Add to dashboard Cite

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“…Hirsutism can be quantified by the androgen level based on the hirsutism score (Ferriman-Gallwey/modified Ferriman-Gallwey) and is the most commonly used clinical diagnostic criterion for hyperandrogenism. Relevant study has shown that the severity of hirsutism is correlated with biochemical hyperandrogenism markers, and hirsutism score has a stronger correlation with FT level, but a lesser extent to TT level ( 33 ). It is speculated that the severity of hirsutism depends mainly on the bioavailable circulating and FT.…”

Section: Discussionmentioning

confidence: 99%

Metformin combined with spironolactone vs. metformin alone in polycystic ovary syndrome: a meta-analysis

Zeng,

Zhang,

Huang

et al. 2023

Front. Endocrinol.

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AimsDue to its high heterogenicity and unclear etiology, there is currently no specific treatment for polycystic ovary syndrome (PCOS). Metformin, as an insulin sensitizer, combined with spironolactone, an antiandrogen medication, may exert complementary effects on PCOS. We therefore performed a meta-analysis of trials in which metformin combined with spironolactone was applied to treat PCOS to evaluate the efficacy and safety of the combination therapy.MethodsWe retrieved the PubMed, Embase, Scopus, Cochrane Library, CNKI, CBM, Wangfang, and VIP databases for literatures published from their inception to December 16, 2022 on the effects of metformin combined with spironolactone in the treatment of PCOS. Inclusion criteria according to P.I.C.O.S criteria were: PCOS patients, metformin combined with spironolactone interventions, metformin alone control group, and randomized controlled trials with the following outcome data: body mass index (BMI), hirsutism score, luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone (TT), fasting blood glucose (FBG), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), and side effects including nausea, vomiting, diarrhea and drug withdrawal.ResultsOur results revealed that metformin combined with spironolactone significantly reduced BMI and TT, but that it exerted no significant effects on hirsutism score, or on FSH or LH concentrations. Combined treatment also resulted in a significant diminution in FBG and insulin resistance using the HOMA-IR when the interventional time was greater than 6 months. In addition, the combination did not have a higher occurrence of adverse reactions than metformin alone.ConclusionCompared with metformin alone, metformin combined with spironolactone therapy may be more effective in reducing BMI and serum androgen levels, but the combination showed no significant effect on the hirsutism score or gonadotropin hormone levels, and was not associated with an elevation in side-effects. Moreover, when the treatment course was greater than 6 months, combination therapy reduced FBG and improved insulin resistance more effectively than metformin alone. However, more research is needed to determine the most effective course of treatment.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022355515.

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“…The gold standard for estimating the density of terminal hairs at nine distinct body locations is presently the (mFG) score 17 . The nine androgen-sensitive body areas include the upper lip, chin, chest, upper and lower back, upper and lower abdomen, upper arm, and thigh [14].…”

Section: Chart 1: Prevalence Ratios Of Global Pool and Different Coun...mentioning

confidence: 99%

Comparison of Modified Ferriman-Gallwey Score and Biochemical Parameters in the Estimation of the Prevalence of Idiopathic Hirsutism Among Women in the Kurdistan Region

Jarallah,

Adil,

Palani

2023

Baghdad J. Biochem. Appl. Biol. Sci.

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The word "hirsutism" describes the development of terminal hairs at androgen-controlled body locations in women, which has distress and adverse psychosocial affects. The diagnosis of hirsutism is the key point in the treatment of unwanted hair growth in women’s body. Present study aimed to evaluate the modified Ferriman-Gallwey (mFG) score and the biochemical hyperandrogenism parameters among Iraqi hirsute women and their association with hirsutism in outpatients clinics in Kalar city, Garmian region, Iraq. This was a cross-sectional study of 100 hirsute women were collected from the outpatients clinic and 26 healthy women in Kalar city. After detailed history taking by using structured questionnaire, physical examination, and the relevant investigations were done, the scoring of hirsutism was indexed according to (mFG) scoring system. Moreover, sera of hormonal markers were measured; which included 17-hydroxyprogesterone (17-OHP), total testosterone (TT), free testosterone (FT), dehydroepiandrosterone (DHEA), s. prolactin, and thyroid stimulating hormone (TSH). No statistically significant differences were found in the median of the sex and related hormones between control subjects and the hirsutism group. Likewise, there were no significant relation between hormonal markers and the rate of hirsutism. While, an intrinsic statistical association was seen between the mFG score with the hirsutism and the rate of hirsutism. Our findings imply that the mFG score system is a significance screening tool and has tremendous importance and utility in establishing the diagnosis of hirsutism.

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Association between biochemical hyperandrogenism parameters and modified Ferriman-Gallwey score in patients with hirsutism in Basrah (Southern Iraq)

Cited by 5 publications

References 15 publications

Outcomes of Pioglitazone and Metformin on Anthropometric, Metabolic and Endocrine variables in POS

Outcomes of Pioglitazone and Metformin on Anthropometric, Metabolic and Endocrine variables in POS

Metformin combined with spironolactone vs. metformin alone in polycystic ovary syndrome: a meta-analysis

Comparison of Modified Ferriman-Gallwey Score and Biochemical Parameters in the Estimation of the Prevalence of Idiopathic Hirsutism Among Women in the Kurdistan Region

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