Association Between Blood Lead Level With High Blood Pressure in US (NHANES 1999–2018)

Huang, Zhongdong

doi:10.3389/fpubh.2022.836357

Cited by 34 publications

(26 citation statements)

References 26 publications

(27 reference statements)

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“…In these four Asian countries, the average blood Pb concentration was 1.44 (3.61) µg/L, higher than the plasma Pb levels (median: 0.94 µg/L; 25th-75th percentile: 0.60-1.47) of participants in our study. And Pb level in our study is also lower compared with reported in previous studies, in which Pb level was associated with higher BP [17,29]. We found no relationship between plasma Pb concentrations and BP may be due to the low plasma Pb levels of the participants in this study.…”

Section: Discussioncontrasting

confidence: 75%

Association joint exposure to zinc, arsenic, cadmium, and lead with blood pressure

Hao

Huang

et al. 2023

Preprint

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Background Previous studies have demonstrated the adverse effect of single metal on blood pressure (BP) by oxidative stress, however, few studies investigated the joint effect of multi-metals co-exposure on BP. We aimed to estimate the association between multi-metal co-exposure and BP. Methods 2,764 residents living in heavy metal-contaminated areas of China for at least 5 years were recruited from August 2016 to July 2017 in this study. The average concentration of plasma zinc (Zn) and lead (Pb) and urine arsenic (As) and cadmium (Cd) were measured using an inductively coupled plasma mass spectrometer. The Ordinary least squares (OLS) linear regression and Bayesian kernel machine regression (BKMR) were utilized to assess the effect of the metals on systolic blood pressure (SBP) and diastolic blood pressure (DBP). All the metals were naturally log-transformed and As and Cd in urine were adjusted for urine creatinine levels. Results A total of 1,859 participants (58.40 ± 13.42 years old, 40.02% men) were included in the final analysis. The OLSlinear analyses showed that Zn and As were positively associated with SBP and DBP, while Cd was negatively associated with SBP and DBP. In the BKMR, we found a significantly positive joint effect of the metal mixture on BP when all the metal concentrations were above their medians. We also found the effects of the interaction between As and Zn on BP. Conclusions In conclusion, our study showed that multi-metal co-exposures caused an increase in BP in the population. Further prospective studies with larger sample sizes are necessary to validate this finding.

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Section: Discussioncontrasting

confidence: 75%

Association joint exposure to zinc, arsenic, cadmium, and lead with blood pressure

Hao

Huang

et al. 2023

Preprint

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“…It is the same as the previous published researches on the analysis of NHANES database ( 14 ), participants meeting one or more of the following criteria were considered to have hypertension: (1) average SBP ≥ 140 mmHg or average DBP ≥ 90 mmHg; (2) individuals with prescribed antihypertensive medications; (3) self-reported hypertension. The criteria of 140/90 mmHg refers to the guideline of International Society of Hypertension ( 15 ).…”

Section: Methodsmentioning

confidence: 99%

Associations between novel anthropometric measures and the prevalence of hypertension among 45,853 adults: A cross-sectional study

Kong²,

Shi³

et al. 2022

Front. Cardiovasc. Med.

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AimsTraditional anthropometric measures, including body mass index (BMI), are insufficient for evaluating the risk of hypertension. We aimed to investigate the association between novel anthropometric indices and hypertension risk in a large population in the United States.MethodsForty-five thousand eight hundred fifty-three participants from the National Health and Nutrition Examination Survey (NHANES) (1999–2018) were enrolled. Social demographic information, lifestyle factors, blood biochemical measurements and anthropometric indices, including body weight, body mass index (BMI), waist circumference, waist-to-height ratio (WtHR), conicity index (CI), a body shape index (ABSI), body roundness index (BRI) and lipid accumulation product (LAP) were collected. Multivariable logistic regression and restricted cubic spline were adopted to investigate the associations between hypertension risk and anthropometric indices. We also performed receiver operating characteristic (ROC) curve analyses to further evaluate the discriminatory powers of anthropometric measurements for screening hypertension risk. Moreover, participants were randomly assigned to the training group and the validation group in a ratio of 3 to 1. A nomogram model based on anthropometric measures was established and validated in the training group and validation group, respectively.ResultsAll of the anthropometric measurements investigated were positively and independently associated with the hypertension risk. Among all anthropometric indices, per-SD increment in ABSI had the highest OR (OR: 3.4; 95% CI: 2.73–4.24) after adjusting for age, sex, race/ethnicity, education, smoking, drinking, diabetes, and eGFR. Moreover, results from restricted cubic splines revealed the non-linear association between anthropometric measurements and hypertension risk. In ROC analyses, CI had superior discriminatory power for hypertension (area under the curve: 0.71; 95% CI: 0.706–0.715; optimal cutoff value: 1.3) compared with other indices. Nomogram model based on age, sex, diabetes, CI and LAP showed favorable predicting ability of hypertension risk with an AUC (95% CI) in training group of 80.2% (79.7–80.6%), and the AUC (95% CI) in validation group was 79.5% (78.3–80.1%). Meanwhile, calibration plot showed good consistency.ConclusionsAnthropometric measurements including BMI, WtHR, CI, ABSI, BRI and LAP are closely associated with hypertension risk in the present study. For better prevention and treatment of hypertension, more attention should be paid to anthropometric indices, especially novel anthropometric indices.

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“…Meanwhile, the cross-section involving Chinese and American participants across all age-stage population demonstrated that the obesity-diabetes association significantly decreased with aging, indicating that the modification of diabetes might be closer in adults than older people (40). In a previous study, the positive association between Pb and blood pressure, not hypertension, was determined (41). Therefore, the group with continuous blood pressure increase was a potentially sensitive subpopulation in this relationship chain.…”

Section: Discussionmentioning

confidence: 88%

Association between blood lead levels and hyperlipidemiais: Results from the NHANES (1999–2018)

Zhang

Liu

Zhang

et al. 2022

Front. Public Health

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BackgroundResearch on the association between blood lead (Pb) and lipid biomarkers have yielded inconsistent results, and epidemiological studies on blood Pb levels and hyperlipidemia are scarce. The present study aimed to examine the association between blood Pb levels and hyperlipidemia in adults from the National Health and Nutrition Examination Survey (NHANES).MethodsA total of 43,196 participants in the NHANES from 1999 to 2018 were included in the final analysis. Hyperlipidemia was determined based on the National Cholesterol Education Program guidelines. Blood Pb levels were assessed using inductively-coupled plasma mass spectrometry. Weighted multivariable logistic regression analysis and subgroup analysis were conducted to determine the correlation between blood Pb levels and hyperlipidemia.ResultsIn the multivariable logistic regression model, high blood Pb levels were significantly associated with hyperlipidemia after adjusting for confounders (OR 1.41; 95%CI: 1.18–1.67). Furthermore, elevated blood Pb levels were associated with an increased risk of hyperlipidemia across the four quartile (Q) groups (Q1: OR 1.00; Q2: OR 1.16 [95%CI: 1.04–1.29]; Q3: OR 1.39 [95%CI: 1.21–1.59]; and Q4: OR 1.33 [95%CI: 1.15–1.54]; P for trend <0.05). Significant moderating effects were found in the subgroup analysis stratified by age, education, hypertension, and diabetes (P < 0.05). In sensitivity analysis, the ORs for hyperlipidemia across the quartiles of blood Pb levels were 1.00, 1.17 (95%CI: 1.05–1.30), 1.42 (95%CI: 1.24–1.62), and 1.38 (95%CI: 1.19–1.60) for Q1, Q2, Q3, and Q4, respectively (P for trend <0.001) after removing adults with arteriosclerotic cardiovascular disease, and the ORs were 1.00, 1.13 (95%CI: 1.01–1.25), 1.38 (95%CI: 1.21–1.56), and 1.32 (95%CI: 1.16–1.52) for Q1, Q2, Q3, and Q4, respectively (P for trend <0.001) after including pregnant women.ConclusionThe current study showed a positive association between blood lead levels and hyperlipidemia.

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Association Between Blood Lead Level With High Blood Pressure in US (NHANES 1999–2018)

Cited by 34 publications

References 26 publications

Association joint exposure to zinc, arsenic, cadmium, and lead with blood pressure

Association joint exposure to zinc, arsenic, cadmium, and lead with blood pressure

Associations between novel anthropometric measures and the prevalence of hypertension among 45,853 adults: A cross-sectional study

Association between blood lead levels and hyperlipidemiais: Results from the NHANES (1999–2018)

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