Association between bone lead concentration and blood pressure among young adults

Abstract

These results suggest that substantial lead exposure during childhood can increase BP during young adulthood.

The Role of Exposure Versus Body Burden Data in Deriving Health Guidance Values∗

“…A number of studies suggest an association between blood/bone lead and small increases in blood pressure (Cheng et al, 2001;Gerr et al, 2002;Hu et al, 1996;Korrick et al, 1999;Rothenberg et al, 2002;Nawrot et al, 2002;Schwartz 1995;Staessen et al, 1994). Lead also affects kidney function; decreased glomerular filtration rate was observed consistently in populations with mean PbB levels <20 μg/dl, and two studies reported effects at PbB <10 μg/dl (Kim et al, 1996;Muntner et al, 2003).…”

Characterizing Golden Eagle Risk to Lead and Anticoagulant Rodenticide Exposure: A Review

“…Kidney function, evaluated by measurements of creatinine clearance rate was significantly higher in subjects with plumbism than in controls, but serum creatinine was not significantly different than in controls subjects. The results from these two studies (Gerr et al 2002;Hu 1991a) suggest the possibility that high childhood exposures to lead may contribute to higher blood pressure in adulthood. However, epidemiological studies of children have not found significant associations between increasing PbB and blood pressure (Factor-Litvak et al 1996;Friedlander 1981;Rogan et al 1978;Selbst et al 1993).…”

“…These studies suggest that bone lead levels may be predictors of certain health outcomes, including neurodevelopmental and behavioral outcomes in children and adolescents (Campbell et al 2000a;Needleman et al 1996Needleman et al , 2002Payton et al 1998); and hypertension and declines in renal function in adults Gerr et al 2002;Hu et al 1996aHu et al , 1998Korrick et al 1999;Rothenberg et al 2002a;Tsaih et al 2004). …”

“…Bone lead, a metric of cumulative or long-term exposure to lead, appears to be a better predictor of lead-induced elevations in blood pressure than PbB Gerr et al 2002;Hu et al 1996a;Korrick et al 1999;Rothenberg et al 2002a). In a recent prospective analysis of the Normative Aging Study, higher patellar lead levels, but not PbB, were associated with higher systolic blood pressure and abnormalities in electrocardiographic conduction (Cheng et al 1998).…”

“…A cross-sectional study of potential associations between blood and bone lead, and blood pressure in older adults was conducted as part of the longitudinal Baltimore Memory Study (Martin et al 2006 The potential effects of childhood exposure to lead on bone lead-blood pressure relationships in adulthood have been examined in a cohort study (Gerr et al 2002). The exposed cohort consisted of 251 people (ages 19-24 years in 1994), who resided in any of five towns near the former Bunker Hill smelter in Silver Valley, Idaho and were between the ages of 9 months and 9 years during the period [1974][1975], when uncontrolled emissions from the smelter resulted in contamination of the region and elevated PbB in local children.…”