Association Between Bone Mineral Density, Bone Turnover Markers, and Serum Cholesterol Levels in Type 2 Diabetes

Yang, Yibing; Liu, Guangwang; Zhang, Yao; Xu, Guo; Yi, Xilu; Liang, Jing; Zhao, Chengcheng; Liang, Jun; Ma, Chao; Ye, Yangli; Yu, Mi; Qu, Xinhua

doi:10.3389/fendo.2018.00646

Cited by 23 publications

(14 citation statements)

References 51 publications

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“…Epidemiological and clinical research revealed constructive outcomes of isoflavone utilization over bone with the danger of building up a few osteoporosis. (6) This study aims to examine the impact of Red clover oil on bone healing in rats histomorphometrically.…”

Section: Introductionmentioning

confidence: 99%

Histomorphometric evaluation of the effects of local application of red cloveroil (trifolium pratense) on bone healing in rats

Al-Ghaban¹,

Jasem²

2020

J Bagh Coll Dent

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Background: Red clover oil (Trifolium pratense) has isoflavones bunches which have estrogen-like exercises and may establish an option in contrast to hormone substitution treatment. The present study investigated the impact of Red clover oil on bone healing in rats by histomorphometric study. Materials and Methods: Intra bony defect was performed in right femur of thirty six healthy male albino rats. Then these rats were randomly divided into three groups (12 rats each): one control and 2 experimental groups. For control, the bony defect was left for normal healing; for the experimental (S) group, the defect was treated with hemostatic absorbable gelatin sponge; and for experimental (RS) group, the bony defect was treated with 0.2 ml red clover oil and covered by haemostatic absorbable gelatin sponge. Six rats from each group were sacrificed at 2 and 4 weeks intervals. Histomorphometric analysis was performed on H&E bone section of all the studied groups which includes counting of bone cells (osteoblasts, osteocytes and osteoclasts), trabecular number, trabecular area and bone marrow space area. Results: Histomorphometric results of bone cells revealed that the combination group stimulated larger numbers of osteoblasts and osteocytes than in sponge and control group. Number of new bone trabeculae, trabecular area and bone marrow space area showed higher mean values in combination groups than others. Highly significant differences between groups were observed in all histomorphometric parameters throughout all durations. Conclusion: Red clover oil stimulated larger numbers of osteoblasts and osteoclasts, indicating increased bone remodeling especially at 2 weeks interval as compared with sponge and control groups. Key words: Bone defect, Red clover, Rats.

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Section: Introductionmentioning

confidence: 99%

Histomorphometric evaluation of the effects of local application of red cloveroil (trifolium pratense) on bone healing in rats

Al-Ghaban¹,

Jasem²

2020

J Bagh Coll Dent

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“…The relationship between blood lipid metabolism and bone mineral density has been widely studied in the general population; there are some potential mechanisms of serum lipid on bone metabolism. Oxysterols should be removed by HDL-C from peripheral tissues, and osteoblasts' differentiation is inhibited by LDL oxidation products, so cholesterol, HDL-C, and LDL-C can direct progenitor MSCs (mesenchymal stem cells) to undergo lipogenic instead of osteogenic differentiation and induce RANKL-(receptor activator of nuclear factor-kB ligand-) dependent osteoclastic differentiation, and our results also showed their negative effects on osteogenic differentiation [11,12]. Trimpou et al [13] observed necrosis of the femoral head under an electron microscope and found that the number and size of fat cells increased significantly, indicating that lipid metabolism may play an important role in the formation of bone geometry.…”

Section: Discussionmentioning

confidence: 51%

Triglyceride Can Predict the Discordance between QCT and DXA Screening for BMD in Old Female Patients

Wang

Yang

2020

Disease Markers

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Summary. Bone mineral density (BMD) data and biochemical indexes of the elderly women in the cadre department were analyzed retrospectively to find out the relationship between the biochemical indexes and the different screening results between dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT). Purpose. This study is aimed at exploring which indicator can predict the discordance between DXA and QCT. Methods. 192 female patients who took BMD screening tests by QCT and DXA were recruited, and the biomarkers were analyzed to study the relationship between the biomarkers and the discordance of two BMD screening methods. Results. There are 42, 78, and 72 female patients in the normal, osteopenia, and osteoporosis groups defined by DXA and 6, 54, and 132 female patients in the corresponding group defined by QCT. DXA was less sensitive than QCT. Cholesterol (CHO) and triglyceride (TG) were all negatively correlated with the discordance between these two methods. When TG > 0.89 mmol/L, the QCT result would be the same as the DXA’s; otherwise, there should be discordance between QCT and DXA. Conclusions. Triglyceride can be used to predict the discordance between QCT and DXA, and clinicians can evaluate patients’ DXA results based on patient triglyceride or cholesterol results as a supplement to QCT results.

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“…Numerous studies investigated the association between cholesterol and BMD in the general population, but conclusions were inconsistent. In most studies, a higher level of cholesterol was found to be associated with an increased risk of osteoporosis or a lower BMD ( 5 – 8 ). A non-association between cholesterol and BMD was also reported ( 9 – 11 ).…”

Section: Discussionmentioning

confidence: 99%

High cholesterol and low triglycerides are associated with total lumbar bone mineral density among adults aged 50 years and over: The NHANES 2017–2020

et al. 2022

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BackgroundThe association between cholesterol and triglycerides with the lumbar bone mineral density (BMD) was widely investigated, but the results remained conflicting. This study aimed to investigate the relationship between total cholesterol, triglycerides, and total lumbar BMD in adults.Materials and methodsThis cross-sectional study included 1,985 individuals aged 50 years and over. The data on total cholesterol, triglycerides, total lumbar BMD, and other covariates were obtained from the National Health and Nutritional (NHANES) between 2017 and March 2020 pre-pandemic. Multivariate logistic regression models were utilized to investigate the association between cholesterol, triglycerides, and total lumbar BMD. Smooth curve fittings and generalized additive models were also used to analyze the potential non-linearity.ResultsA total of 901 men and 1,084 women with a mean age of 63.02 ± 8.72 years (age 50–80 years) were included in this study. In multivariate regression analysis, the association between cholesterol and total lumbar BMD was negative (β = −0.026, 95% CI: −0.033, −0.020). This relationship still existed after adjusted for gender and race (β = −0.018, 95% CI: −0.025, −0.012) and fully adjusted for all covariates (β = −0.022, 95% CI: −0.029, −0.015). The association between triglycerides and total lumbar BMD was positive (β = 0.024, 95% CI: 0.017, 0.031). This relationship still existed after adjusted for gender and race (β = 0.021, 95% CI: 0.015, 0.028) and fully adjusted for all covariates (β = 0.021, 95% CI: 0.014, 0.028). In threshold effect analysis, the relationship between triglycerides and total lumbar BMD was an inverted U-shaped curve with the inflection point at 2.597 mmol/L.ConclusionHigh levels of total cholesterol and relatively low levels of triglycerides are significantly associated with the total lumbar BMD in adults aged 50 years and over.

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Association Between Bone Mineral Density, Bone Turnover Markers, and Serum Cholesterol Levels in Type 2 Diabetes

Cited by 23 publications

References 51 publications

Histomorphometric evaluation of the effects of local application of red cloveroil (trifolium pratense) on bone healing in rats

Histomorphometric evaluation of the effects of local application of red cloveroil (trifolium pratense) on bone healing in rats

Triglyceride Can Predict the Discordance between QCT and DXA Screening for BMD in Old Female Patients

High cholesterol and low triglycerides are associated with total lumbar bone mineral density among adults aged 50 years and over: The NHANES 2017–2020

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