Association between Bone Mineral Density and Fat Mass Independent of Lean Mass and Physical Activity in Women Aged 75 or Older

Abstract

(1) Osteoporosis and sarcopenia are frequent pathologies among the geriatric population. The interlink between these two diseases is supported by their common pathophysiology. The aim is to explore the relationship between bone mineral density (BMD) and body composition in women aged 75 or older. (2) From January 2016 to December 2019, women aged 75 or older of Caucasian ethnicity, who were addressed to perform a biphoton absorptiometry (DXA), were included in this observational study. Femoral neck T-score, lean mass, fat mass, and physical performances were measured. (3) The mean age of 101 patients included was 84.8 (±4.9) years old. Osteoporosis was present in 72% of patients. According to EWGSOP criteria, 37% of patients were sarcopenic. Osteosarcopenia was present in 34% of patients. The femoral neck T-score was significantly associated with fat mass (β = 0.02, 95% CI (0.01; 0.03), p < 0.05) in multivariable analysis. Osteosarcopenic patients had significantly lower fat mass (16.2 kg (±6.8) vs. 23.1 kg (±10.8), p < 0.001) and body mass index (BMI) (20.7 kg/m2 (±2.8) vs. 26.7 kg/m2 (±5.6), p < 0.001). (4) In postmenopausal women, fat mass is estimated to provide hormonal protection. While osteosarcopenia is described as a lipotoxic disease, fat mass and BMI would appear to protect against the risk of osteosarcopenia. This raises questions about the relevance of BMI and DXA.

Global epidemiological features and impact of osteosarcopenia: A comprehensive meta‐analysis and systematic review

“…Sixty-three of the 66 studies reported the prevalence of osteosarcopenia. For related factors of osteosarcopenia, six studies 15,25,[28][29][30][31] reported an association between frailty and osteosarcopenia, six 16,29,[32][33][34][35] reported age, while four 16,30,34,35 reported gender and four 16,30,35,36 reported malnutrition. In terms of outcome, seven 12,[37][38][39][40][41][42] reported data on fractures, three 37,39,41 on falls, and five 14,24,37,40,43 on mortality.…”

Nghiên cứu mối liên quan giữa mật độ xương với khối mỡ, khối nạc, nồng độ leptin, adiponectin huyết thanh ở người trên 40 tuổi có hội chứng chuyển hóa

“…Gợi ý sự lắng đọng chất béo android và tỷ lệ chất béo android/gynoid không có lợi, thậm chí có thể có hại cho xương và phân bố chất béo gynoid tốt hơn android [3]. Marie Mathieu (2021), Tscore CXĐ có liên quan thuận đáng kể với khối lượng mỡ (β=0,02, 95%CI: 0,01-0,03, p<0,05) trong phân tích đa biến. Bệnh nhân giảm MĐX có khối lượng mỡ thấp hơn đáng kể (16,2 ± 6,8kg) so với (23,1 ± 10,8kg), p<0,001 [8].…”

“…Marie Mathieu (2021), Tscore CXĐ có liên quan thuận đáng kể với khối lượng mỡ (β=0,02, 95%CI: 0,01-0,03, p<0,05) trong phân tích đa biến. Bệnh nhân giảm MĐX có khối lượng mỡ thấp hơn đáng kể (16,2 ± 6,8kg) so với (23,1 ± 10,8kg), p<0,001 [8].…”