Association between brain-derived neurotrophic factor levels and obstructive sleep apnea: a systematic review and meta-analysis

Khalaji, Amirmohammad; Behnoush, Amir Hossein; Shobeiri, Parnian; Saeedian, Behrad; Teixeira, Antônio Lúcio; Rezaei, Nima

doi:10.1007/s11325-022-02707-x

Cited by 14 publications

(9 citation statements)

References 47 publications

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“…Nevertheless, compared with the C-WISC scores of normal children in previous studies (25), the scores of PIQ, VIQ, and FIQ in the PS group were not significantly lower. However, this did not suggest that cognitive impairment does not exist in PS A few studies have looked at the relationship between BDNF and OSA in adults and showed conflicting results, as some have found a relationship between BDNF and OSA (26,27), whereas others reported no significant difference (28,29). In addition, the association between circulating levels of BDNF and children with SDB is also still unclear.…”

Section: Discussionmentioning

confidence: 94%

“…A few studies have looked at the relationship between BDNF and OSA in adults and showed conflicting results, as some have found a relationship between BDNF and OSA ( 26 , 27 ), whereas others reported no significant difference ( 28 , 29 ). In addition, the association between circulating levels of BDNF and children with SDB is also still unclear.…”

Section: Discussionmentioning

confidence: 99%

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Relationship between serum brain-derived neurotrophic factor and cognitive impairment in children with sleep-disordered breathing

Feng

Ma²,

Chen³

et al. 2023

Front. Pediatr.

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BackgroundAs an important neuroprotective factor, the brain-derived neurotrophic factor (BDNF) may have a key role in cognitive impairment in children with sleep-disordered breathing (SDB). The main aim of this study was to compare the levels of BDNF and tyrosine kinase receptor B (TrkB) in normal children and those with obstructive sleep apnea (OSA) and primary snoring (PS) and to explore a possible link between BDNF/TrkB, inflammation, and SDB with cognitive impairment in children.MethodsA total of 44 OSA children and 35 PS children who completed polysomnography between October 2017 and October 2019 were enrolled. At the same time, 40 healthy children during the same period were included as a control. Enzyme-linked immunosorbent assay was used to measure serum indices of BDNF, TrkB, interleukin-1beta (IL-1β), and tumor necrosis factor-alpha (TNF-α). Correlation and pooled analyses were performed between the cognitive scores and four serological indicators. Logistic regression was used to analyze the risk factors for cognitive impairment.ResultsSignificant differences were found in serum BDNF, TrkB, IL-1β, and TNF-α between the three groups (all P < 0.01). The serum BDNF and TrkB in the OSA and PS groups were lower than those in the control group, whereas the serum IL-1β and TNF-α were higher than those in the control group (all P < 0.05). Moreover, among these four indices, the strongest correlation was found between BDNF and the Chinese Wechsler Intelligence Scale (all P < 0.05). Logistic regression analysis revealed a correlation between OSA status, TrkB, and course of mouth breathing and cognitive status.ConclusionThe levels of serum BDNF and TrkB were related to cognitive impairment in children with SDB. Also, BDNF and TrkB could be used as noninvasive and objective candidate markers and predictive indices of cognitive impairment in children with SDB.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Relationship between serum brain-derived neurotrophic factor and cognitive impairment in children with sleep-disordered breathing

Feng

Ma²,

Chen³

et al. 2023

Front. Pediatr.

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“…To address this, researchers are exploring more easily measurable biomarkers to guide the diagnosis of OSA. [31][32][33][34][35] This study is one such effort, reviewing serum and plasma levels of endocan (ESM-1), a marker of endothelial damage in patients with severe and non-severe OSA and control groups. Endocan levels were increased in patients compared with controls, with a more pronounced increase in severe cases.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Role of Circulating Endocan Levels in Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis

et al. 2023

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Endocan, as an endothelial cell damage marker, plays role in several cardiovascular and non-cardiovascular diseases. This systematic review and meta-analysis evaluates the role of endocan as a potential diagnostic or prognostic biomarker for obstructive sleep apnea (OSA). International databases including PubMed, Embase, Web of Science, and Scopus were searched for relevant studies assessing endocan levels in OSA patients compared with healthy controls or within different severities or comorbidities of OSA. Random-effect meta-analysis was performed in order to calculate the standardized mean difference (SMD) and 95% confidence interval (CI) of serum/plasma endocan in all comparisons. A total of 10 studies were included in our systematic review, among which seven were used in meta-analysis. Meta-analysis showed that endocan levels were significantly higher in patients with OSA compared with healthy controls (SMD 1.29, 95% CI 0.64–1.93, P < .001) and this was not different between serum and plasma subgroups. However, there was no statistical difference between severe and non-severe OSA patients (SMD .64, 95% CI −.22 to 1.50, P = .147). Considerably, higher endocan levels in patients with OSA in comparison with non-OSA individuals might have clinical implications. This association warrants further research due to its potential use as a diagnostic and prognostic biomarker.

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“…Their result showed an increased BDNF in FM patients in comparison with healthy controls, which was independent of age, gender, and illness duration [ 47 ]. The serum BDNF has been investigated in several clinical manifestations of FM and also seems to be associated with some, such as depression, mood disorders, and dysfunctional eating behavior [ 41 , 61 – 63 ].…”

Section: Discussionmentioning

confidence: 99%

Brain-derived neurotrophic factor in fibromyalgia: A systematic review and meta-analysis of its role as a potential biomarker

Behnoush,

Khalaji,

Khanmohammadi

et al. 2023

PLoS ONE

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Background Fibromyalgia (FM) is a form of chronic pain disorder accompanied by several tender points, fatigue, sleeping and mood disturbances, cognitive dysfunction, and memory problems. Brain-derived neurotrophic factor (BDNF) is also a mediator of neurotrophin for many activity-dependent processes in the brain. Despite numerous research studies investigating BDNF in FM, contradictory results have been reported. Thus, we investigated the overall effect shown by studies to find the association between peripheral BDNF concentrations and its gene polymorphisms with FM. Methods A systematic search in online international databases, including PubMed, Cochrane Library, Embase, the Web of Science, and Scopus was performed. Relevant studies assessing BDNF levels or gene polymorphism in patients with FM and comparing them with controls were included. Case reports, reviews, and non-English studies were excluded. We conducted the random-effect meta-analysis to estimate the pooled standardized mean difference (SMD) or odds ratio (OR) and 95% confidence interval (CI). Results Twenty studies were found to be included composed of 1,206 FM patients and 1,027 controls. The meta-analysis of 15 studies indicated that the circulating BDNF levels were significantly higher in FM (SMD 0.72, 95% CI 0.12 to 1.31; p-value = 0.02). However, no difference between the rate of Val/Met carrier status at the rs6265 site was found (p-value = 0.43). Using meta-regression, the sample size and age variables accounted for 4.69% and 6.90% of the observed heterogeneity of BDNF level analysis, respectively. Conclusion Our meta-analysis demonstrated that FM is correlated with increased peripheral BDNF levels. This biomarker’s diagnostic and prognostic value should be further investigated in future studies.

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Association between brain-derived neurotrophic factor levels and obstructive sleep apnea: a systematic review and meta-analysis

Cited by 14 publications

References 47 publications

Relationship between serum brain-derived neurotrophic factor and cognitive impairment in children with sleep-disordered breathing

Relationship between serum brain-derived neurotrophic factor and cognitive impairment in children with sleep-disordered breathing

Diagnostic Role of Circulating Endocan Levels in Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis

Brain-derived neurotrophic factor in fibromyalgia: A systematic review and meta-analysis of its role as a potential biomarker

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