Association between brominated flame retardants exposure and markers of oxidative stress in US adults: An analysis based on the National Health and Nutrition Examination Survey 2007–2016

Han, Lu; Wang, Qi

doi:10.1016/j.ecoenv.2023.115253

Cited by 9 publications

(5 citation statements)

References 48 publications

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“…It is important to note that variations in results may occur due to differences in the exposure stages (children vs. adults) ( 33 ), choice of statistical models, and any undetected covariates. In addition, BRFs have been demonstrated to be significantly correlated with numerous cardiovascular risk factors ( 23 , 34 – 36 ). For example, Lu et al ( 36 ) reported that BFR mixtures were found to have adverse effects on oxidative stress markers, with PBB153 being linked to elevated levels of bilirubin ( β : 0.042, 95% CI: 0.022, 0.063) and gamma-glutamyl transferase ( β : 0.042, 95% CI: 0.022, 0.063).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, BRFs have been demonstrated to be significantly correlated with numerous cardiovascular risk factors ( 23 , 34 – 36 ). For example, Lu et al ( 36 ) reported that BFR mixtures were found to have adverse effects on oxidative stress markers, with PBB153 being linked to elevated levels of bilirubin ( β : 0.042, 95% CI: 0.022, 0.063) and gamma-glutamyl transferase ( β : 0.042, 95% CI: 0.022, 0.063). A cross-sectional study observed that PBB153 heightened the risk of Metabolic syndrome significantly (OR: 2.38; 95% CI: 1.73, 3.30) ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…In addition, BRFs have been demonstrated to be significantly correlated with numerous cardiovascular risk factors (23,(34)(35)(36). For example, Lu et al (36) reported that BFR mixtures were found to have (17,38). And finally, BFRs can also stimulate the body to produce more reactive oxygen species and free radicals, resulting in increased levels of oxidative stress in the body, which may further damage vascular endothelial cells and cause cardiovascular disease (39).…”

Section: Discussionmentioning

confidence: 99%

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Single and combined association between brominated flame retardants and cardiovascular disease: a large-scale cross-sectional study

Yin,

Xu,

Zou

et al. 2024

Front. Public Health

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IntroductionThe single and combined association between brominated flame retardants (BFRs) and cardiovascular diseases (CVD) has remained unelucidated. This research aimed at exploring the associations between mixture of BFRs and CVD.MethodsThis research encompassed adult participants from the National Health and Nutrition Examination Survey in 2005–2016. The weighted quantile sum (WQS) model and quantile g-computation (QGC) model were applied to examine the combined effects of BFRs mixture on CVD.ResultsIn this research, overall 7,032 individuals were included. In comparison with the lowest quartile, the highest quartile of PBB153 showed a positive association with CVD, with odds ratio (OR) values and 95% confidence intervals (CI) of 19.2 (10.9, 34.0). Furthermore, the acquired data indicated that PBB153 (OR: 1.23; 95% CI: 1.02, 1.49), PBB99 (OR: 1.29; 95% CI: 1.06, 1.58), and PBB154 (OR: 1.29; 95% CI: 1.02, 1.63) were linked to congestive heart failure. PBB153 was also related to coronary heart disease (OR: 1.29; 95% CI: 1.06, 1.56). Additionally, a positive correlation between the BFRs mixture and CVD (positive model: OR: 1.23; 95% CI: 1.03, 1.47) was observed in the weighted quantile sum (WQS) model and the quantile g-computation (QGC) model.DiscussionTherefore, exposure to BFRs has been observed to heighten the risk of cardiovascular disease in US adults, particularly in the case of PBB153. Further investigation is warranted through a large-scale cohort study to validate and strengthen these findings.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Single and combined association between brominated flame retardants and cardiovascular disease: a large-scale cross-sectional study

Yin,

Xu,

Zou

et al. 2024

Front. Public Health

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“…The WQS analysis is a multivariate approach that evaluates the combined effect of all predictor variables on the outcome using a weighted index. The relative weight of each variable is used to determine its contribution to the overall exponential effect [ 15 ].…”

Section: Statistical Analysesmentioning

confidence: 99%

Synergistic Effects of Nutrients on Musculoskeletal Health in Gerontology: Understanding the Combined Impact of Macronutrients and Micronutrients

Liu,

Qian,

Shi

et al. 2024

Nutrients

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With the global aging population, addressing prevalent age-related conditions such as osteoporosis and sarcopenia is crucial. Traditional nutritional strategies focusing on single nutrients like calcium, vitamin D, or protein have limitations, prompting a nuanced exploration of the relationship between aging, nutrition, and musculoskeletal health. This cross-sectional study examines the complex interplay between dietary intake of macronutrients, common micronutrients, and water, as well as their association with musculoskeletal health in adults aged 50 to 80 years, using U.S. National Health and Nutrition Examination Survey data (NHANES). Employing multiple linear regression, restricted cubic splines, weighted quantile sum (WQS), and quantile-based g-computation (QGC) regression models, our initial analysis using the WQS model revealed that a one-quartile increase in mixed macronutrient intake was associated with a significant 0.009 unit increase in bone mineral density (BMD) and a 0.670 unit increase in grip strength, while a similar increase in mixed micronutrient intake showed a 0.007 unit increase in BMD and a 0.442 unit increase in grip strength. Our findings highlight the importance of a balanced dietary approach in promoting musculoskeletal health in the elderly, offering holistic strategies for overall well-being.

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Effect of brominated flame retardants exposure on liver function and the risk of non-alcoholic fatty liver disease in the US population

Chen,

Hu,

et al. 2024

Ecotoxicology and Environmental Safety

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Association between brominated flame retardants exposure and markers of oxidative stress in US adults: An analysis based on the National Health and Nutrition Examination Survey 2007–2016

Cited by 9 publications

References 48 publications

Single and combined association between brominated flame retardants and cardiovascular disease: a large-scale cross-sectional study

Single and combined association between brominated flame retardants and cardiovascular disease: a large-scale cross-sectional study

Synergistic Effects of Nutrients on Musculoskeletal Health in Gerontology: Understanding the Combined Impact of Macronutrients and Micronutrients

Effect of brominated flame retardants exposure on liver function and the risk of non-alcoholic fatty liver disease in the US population

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