Association between C reactive protein level and depressive symptoms in an elderly Korean population: Korean Social Life, Health and Aging Project

Song, Bo; Lee, Ju Mi; Choi, Wungrak; Youm, Yoosik; Chu, Sang Hui; Park, Yeong Ran; Kim, Hyeon Chang

doi:10.1136/bmjopen-2014-006429

Cited by 31 publications

(29 citation statements)

References 34 publications

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“…Our findings are consistent with prior population-based studies that found no significant association between CRP and depression independent of BMI 12 15. Our findings also align with other studies that found no association between CRP and depression independent of other covariates related to depression, including antidepressant use and chronic illness 10 11 13 16 27…”

Section: Discussionsupporting

confidence: 92%

Association between C Reactive Protein and Depression in a Population of Healthy Adults: The Cooper Center Longitudinal Study

Khan

Léonard

DeFina

et al. 2020

Journal of Investigative Medicine

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The relationship between depression and inflammation is currently a topic of much interest. Previous studies have produced mixed results regarding the association between depression and high-sensitivity C reactive protein (hs-CRP). The aim of this report was to determine the association between hs-CRP and depression in a large sample of healthy adults. This is a cross-sectional study of 26,638 healthy adults seen for preventive medical examinations between December 2000 and August 2018 at the Cooper Clinic in Dallas, Texas. Multivariable logistic regression was used to evaluate the association between hs-CRP levels and depressive symptoms as measured by the 10-item Center for Epidemiologic Studies Depression Scale. Covariates included race, age, education, smoking history, alcohol use, menopausal status, body mass index (BMI), and medication use. The Hs-CRP level demonstrated a weakly positive association with depressive symptoms (OR 1.06 per mg/L, 95% CI 1.03 to 1.09 for women; OR 1.05 per mg/L, 95% CI 1.02 to 1.09 for men) that became insignificant when controlling for BMI in women (OR 1.02 per mg/L, 95% CI 0.98 to 1.05) and men (OR 1.02 per mg/L, 95% CI 0.98 to 1.05). Adjusting for antidepressant and statin use did not affect the association between hs-CRP and depressive symptoms in women (OR 0.99 per mg/L, 95% CI 0.96 to 1.03) or men (OR 1.01 per mg/L, 95% CI 0.97 to 1.05). Levels of hs-CRP were not associated with depression independent of BMI in a predominantly white, male population of higher socioeconomic status. This finding suggests that associations between hs-CRP and depression may be explained by obesity, which warrants further investigation into shared pathways between obesity and depression.

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Section: Discussionsupporting

confidence: 92%

Association between C Reactive Protein and Depression in a Population of Healthy Adults: The Cooper Center Longitudinal Study

Khan

Léonard

DeFina

et al. 2020

Journal of Investigative Medicine

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“…However, most studies support a positive association between CRP and depressive symptoms both in men and women. [ 11 – 18 , 36 , 37 ] The mechanisms for the association between CRP and depressive symptoms are unclear, but various hypotheses have been develop to explain the relationship since CRP cannot cross the blood-brain barrier, and directly affect emotion regulating area in the brain. [ 21 ]…”

Section: Discussionmentioning

confidence: 99%

“…Similar evidences of the positive associations have been found in other studies. [ 11 – 18 ] However, contradictory evidences have been found in several studies. Chaiton et al, [ 19 ] Douglas et al, [ 20 ] and Au et al [ 21 ] found no significance association between CRP and depressive symptoms in the general population.…”

Section: Introductionmentioning

confidence: 99%

No association between C-reactive protein and depressive symptoms among the middle-aged and elderly in China

Zhang

et al. 2018

Medicine

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The depressive symptoms have been associated with increased disabilities, and the depressive symptoms-related elevation of high C-reactive protein (CRP) has been proposed as a possible mechanism. We examined the relations between CRP and depressive symptoms among the middle-aged and elderly in China.A longitudinal sample of the middle-aged and elderly (4404 men and 5055 women) who were interviewed in the 2011 China Health and Retirement Longitudinal Study was used. A multivariate logistic regression analysis was used to examine the effects of sociodemographic characteristics, lifestyle, activity status, physical exercise, systolic blood pressure, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides, body mass index (BMI), and CRP levels on depressive symptoms.The mean age in the study was 60.26 years [standard deviation (SD) ± 9.25; 46.56% men]. The mean CPR level was 2.79 mg/L (range, 0.01–178.10; SD ± 7.80). Depression scores ranged from 0 to 30 with a mean 8.65 (SD ± 6.33). The prevalence of depressive symptoms was 38.49% in the total population, 31.04% in men and 44.99% in men. Compared with baseline CRP levels (≤1.00 mg/L), the depressive symptoms are only weakly correlated with CRP levels among women [CRP 1.01–3.00 mg/L: odds ratio (OR) = 0.85, 95% confidence interval (CI) = 0.73–0.98; CRP 3.01–10.00 mg/L: OR = 1.25, 95% CI = 1.03–1.51; CRP >10 mg/L: OR = 1.41, 95% CI = 1.06–1.88]. After adjusting for age, education, marital status, hukou, residence, cigarette smoking, alcohol drinking, eating meals, activity status, major accidental injury, diseases, health status, physical exercise, systolic blood pressure, LDL, HDL, triglycerides, and BMI, depressive symptoms were not associated with subsequent high CPR levels among the middle-aged and elderly (CRP 1.01–3.00 mg/L: OR = 0.93, 95% CI = 0.83–1.03; CRP 3.01–10.00 mg/L: OR = 0.95, 95% CI = 0.82–1.10; CRP >10 mg/l: OR = 1.11, 95% CI = 0.88–1.39).Our data do not support an association between CRP and depressive symptoms in both middle-aged and elderly men and women among china.

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“…Even if not significantly different in the descriptive analyses, all of the above-mentioned variables were entered into the multiple logistic regression models for insomnia because we assumed that each variable could affect the other variables. Because marked sex differences were found in previous studies of our KSHAP sample, 24 25 26 27 28 we evaluated interaction effects between sex and all other variables by adding interaction terms into the regression model to maximize the number of independent variables.…”

Section: Methodsmentioning

confidence: 99%

Factors Associated with Insomnia among the Elderly in a Korean Rural Community

Kim

Joo

Baek

et al. 2017

Psychiatry Investig

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ObjectiveSleep disturbance is common in the elderly, which is result from multi-factorial causes encompassing socio-demographic, behavioral, and clinical factors. We aimed to identify factors associated with insomnia among the elderly in a rural community in South Korea, a country with a rapidly growing aged population.MethodsThis cross-sectional study used the data from the second wave of the Korean Social life, Health and Ageing Project, which is a cohort study of individuals living in a typical rural community in South Korea. Socio-demographic, behavioral, and clinical characteristics were obtained through face-to-face interviews. Various factors suspected to be associated with insomnia were compared between elderly participants with and without insomnia, and multiple logistic regression analyses were conducted to identify independent risk factors for insomnia.ResultsWe found that 32.4% of 509 participants (72.8±7.7 years old) had insomnia. Female sex [odds ratio (OR)=2.19], low education level (OR=2.44), current smoking (OR=2.26), number of chronic diseases (OR=2.21 for 2–3 chronic diseases; OR=2.06 for 4 or more chronic diseases), and depression (OR=2.53) were independently associated with insomnia.ConclusionWe found that sex, education, chronic disease, and depression independently increase the risk of insomnia of the elderly in a Korean rural community. To overcome the elderly's insomnia, interventions should target modifiable factors such as depression. To promote active aging, longitudinal studies of factors associated with insomnia among the elderly should be performed in different regions and communities.

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Association between C reactive protein level and depressive symptoms in an elderly Korean population: Korean Social Life, Health and Aging Project

Cited by 31 publications

References 34 publications

Association between C Reactive Protein and Depression in a Population of Healthy Adults: The Cooper Center Longitudinal Study

Association between C Reactive Protein and Depression in a Population of Healthy Adults: The Cooper Center Longitudinal Study

No association between C-reactive protein and depressive symptoms among the middle-aged and elderly in China

Factors Associated with Insomnia among the Elderly in a Korean Rural Community

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