Association between calcitriol and paricalcitol with oxidative stress 					in patients with hemodialysis

Yeter, Hasan Haci; Korucu, Berfu; Bali, Elif Burcu; Derici, Ülver

doi:10.1024/0300-9831/a000641

Cited by 3 publications

(3 citation statements)

References 31 publications

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“…Data on calcitriol was not measured in our study. However, most dialysis patients need supplementation of calcitriol, or other forms of active vitamin D. Use of active vitamin D in patients with dialysis is suggested to decrease oxidative stress and inflammation and decrease CVD risk [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Vitamin D Deficiency among Hemodialysis Patients in Palestine: A Cross-Sectional Study

Nazzal

Hamdan

Natour

et al. 2021

International Journal of Nephrology

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Introduction. The level of vitamin D status and its relationship to kidney function and liver function among patients with and without type 2 diabetes were not studied among Palestinian hemodialysis patients before. The aim of this study was to assess the status of vitamin D in hemodialysis patients with and without type 2 diabetes and its determinants. Methods. Data were collected on 163 patients on hemodialysis therapy in the Nephrology Department at Najah National University Hospital. Information on age, sex, plasma 25 (OH)D, serum calcium, serum phosphate, parathyroid hormone, dialysis period, hypertension, diabetes, ALT, AST, albumin, alkaline phosphates, and BMI was obtained from the medical records. Data were analyzed using SPSS. Findings. The mean level of 25 (OH)D was 17.3 ± 10.5 ng/ml. Only 12.9% of subjects had 25 (OH)D levels >30 ng/ml, whereas 65% had levels between 10 and 30 ng/ml; the remaining 22.1% were severely vitamin D deficient (<10 ng/ml). Vitamin D deficiency was more prevalent among females. It was not related to PTH, calcium, kidney, or liver function tests. Conclusion. Vitamin D deficiency is highly prevalent among patients on hemodialysis with or without DM2.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Vitamin D Deficiency among Hemodialysis Patients in Palestine: A Cross-Sectional Study

Nazzal

Hamdan

Natour

et al. 2021

International Journal of Nephrology

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“…Paricalcitol is an active vitamin D analog that has non-hypercalcemic effects. Paricalcitol use in hemodialysis patients is associated with as much increase in antioxidant parameters as with active vitamin D (Yeter et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Can Paricalcitol Increase the Effectiveness of N-Acetylcysteine in Contrast Induced Acute Kidney Prophylaxis in Rats? A Biochemical and Histopathological Study

et al. 2022

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N-Acetylcysteine (NAC) is used for contrast induced acut kidney injury (CI-AKI) prophylaxis because of its antioxidant effects. Paricalcitol, which has reno-protective effects, is likely to provide a more effective prophylaxis when added to NAC treatment. The study was designed based on this hypothesis. The study was organised to include 4 groups each consisting of 7 rats. Group 1 was the control group, and Group 2 included rats with CI-AKI. Rats in Group 3 were administered NAC at a dose of 100 mg/kg via oral gavage once a day for 5 days. Rats in group 4 were administered paricalcitol at a dose of 0.4 mcg/kg once a day for 5 days in addition to NAC. CI-AKI was induced after the treatments in both groups. The study was terminated on the sixth day. Samples were collected from the rats' sera and kidney tissues to study oxidant and antioxidant parameters; kidney function tests were also studied. There were significant differences between the contrast nephropathy group (Group 2) and NAC and NAC+paricalcitol groups with respect to serum urea and creatinine levels. When the same groups were compared regarding oxidant (TOS-MDA) and antioxidant (TAC-Paraoxonase) parameters, we observed that the oxidant parameters increased in serum and kidney tissue samples with NAC use, and that effect was strengthened by the addition of paricalcitol to NAC treatment. However, despite increased antioxidant effectiveness, we observed no decrease in urea and creatinine levels when paricalcitol was added for CI-AKI in rats. There was no significant difference between Group 3 and Group 4. Paricalcitol provides a more potent antioxidant effect in both serum and kidney tissue samples when added to NAC treatment in rats with CI-AKI. Despite increased antioxidant parameters, however, paricalcitol does not provide a significant decrease in urea and creatinine levels.

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“…Previous studies documented that serum vitamin D levels were negatively correlated with serum IL-6 levels in stroke individuals or patients with different states of acute or chronic in ammation [12,13].…”

Section: Introductionmentioning

confidence: 97%

Interleukin-6 and vitamin D serum levels in patients with obstructive sleep apnea syndrome before and after long-term continuous positive airway pressure treatment

Kotsiou

Siachpazidou

Pastaka

et al. 2020

Preprint

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Background: Hypoxia induces the production of adipocyte-derived mediators such as IL-6 in obstructive sleep apnea syndrome (OSAS). Low serum 25-hydroxyvitamin D (25(OH)D) levels have been linked to OSAS susceptibility. No data exist to assess whether there has been a correlation between vitamin D and IL-6 serum levels. The effect of CPAP therapy on IL-6 or 25(OH)D levels has yet to be investigated sufficiently in OSAS. We aimed at determining the serum levels of 25(OH)D and IL-6 in OSAS patients compared to non-apneic controls, investigating a possible correlation between 25(OH)D and IL-6 levels and evaluating the changes in IL-6 and 25(OH)D concentrations after twelve months of CPAP therapy in OSAS patients.Methods: 15 OSAS patients diagnosed by polysomnography and 15 non-apneic controls were included in the study. Serum IL-6 and 25(OH)D levels were measured before and after twelve-month CPAP therapy in the whole population and OSAS group, respectively.Results: IL-6 levels were significantly elevated in the OSAS group than the controls. IL-6 levels were positively correlated with OSAS severity, nocturnal hypoxemia, and body mass index (BMI). No difference was detected in 25(OH)D serum levels between groups. We found no correlation between IL-6 and 25(OH)D serum levels in two groups. No effect on IL-6 or 25(OH)D levels was detect after one year of effective CPAP therapy in OSAS patients.Conclusions: IL-6 levels were correlated with OSAS severity, hypoxemia, and BMI. No correlation between 25(OH)D and IL-6 levels and no effect of long-term CPAP on biomarkers were found in OSAS patients.

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Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

Cited by 3 publications

References 31 publications

Prevalence of Vitamin D Deficiency among Hemodialysis Patients in Palestine: A Cross-Sectional Study

Prevalence of Vitamin D Deficiency among Hemodialysis Patients in Palestine: A Cross-Sectional Study

Can Paricalcitol Increase the Effectiveness of N-Acetylcysteine in Contrast Induced Acute Kidney Prophylaxis in Rats? A Biochemical and Histopathological Study

Interleukin-6 and vitamin D serum levels in patients with obstructive sleep apnea syndrome before and after long-term continuous positive airway pressure treatment

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