Association Between Cardiac Valvular Calcification and Serum Fetuin-A Levels in Renal Transplant Recipients

Koçyiğit, İsmail; Ünal, Aydın; Elçik, Deniz; Korkar, Hafsa; Şen, Ahmet; Yaşan, Mustafa; Sipahioğlu, Murat Hayri; Tokgöz, Bülent; Oymak, Oktay

doi:10.1016/j.transproceed.2015.04.008

Cited by 12 publications

(5 citation statements)

References 27 publications

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“…It is not known if KT reverses valvular calcification. Kocyigit et al examined the prevalence of aortic and mitral valve calcification in KT recipients [86]. Of 89 KT recipients examined, only 14 patients had no evidence of valvular calcification.…”

Section: A L V U L a R H E A R T D I S E A S E I N T H E K I D N E Y T R A N S P L A N T R E C I P I E N Tmentioning

confidence: 99%

Cardiovascular disease in the kidney transplant recipient: epidemiology, diagnosis and management strategies

Rangaswami

Mathew

Parasuraman

et al. 2019

Nephrology Dialysis Transplantation

151

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Section: A L V U L a R H E A R T D I S E A S E I N T H E K I D N E Y T R A N S P L A N T R E C I P I E N Tmentioning

confidence: 99%

Cardiovascular disease in the kidney transplant recipient: epidemiology, diagnosis and management strategies

Rangaswami

Mathew

Parasuraman

et al. 2019

Nephrology Dialysis Transplantation

151

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“…Present study showed that patients with high Fetuin-A, high Lp(a) and low MGP should seek early examination and diagnosis for CAVD. A study conducted by Kocyigit et al showed that compared with patients without valve calcification, the level of serum Fetuin-A in patients with aortic valve calcification was significantly higher [ 13 ]. Di Minno et al analyzed 2283 patients with aortic stenosis and 1549 healthy people.…”

Section: Discussionmentioning

confidence: 99%

Impact of Fetuin-A, Lp(a), matrix gla protein and macrophage density on calcific aortic valve disease: a clinical study

Liu

Xie

2022

Lipids Health Dis

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Background Calcific aortic valve disease (CAVD) has a substantial and increasing burden in the ageing population with occult onset.Present study aimed to assess association of clinical characteristics of these patients and occurrence of CAVD. Methods Patients diagnosed with CAVD and those receiving healthy medical examination in our hospital from January 2019 to February 2021 were enrolled in this retrospective study. Clinical characteristics, ultrasonic indicators, serological indicators and histology of CAVD were collected and compared among different groups. Logistic regression and Pearson correlation analysis was used to explore relationship between these indexes and occurrence of CAVD. Results DBP, SBP, LVESD, LVEDD, IVS, PW, AV Vmax, TC, TG, LDL-C, Fetuin-A, Lp(a) in severe group were higher than mild, moderate and control groups (P<0.05), while those indexes of patients in moderate group were higher than that in mild and controlled groups (P<0.05). Besides, theses indexes of patients in mild group were also higher than that of controlled one (P<0.05). However, LVEF, HDL-C and MGP of patients in severe group was the lowest (P<0.05), while those in moderate group were lower than mild and controlled groups. Moreover, these indexes in mild group were also lower than control group (P<0.05). In Logistic regression analysis, MGP, Fetuin-A and Lp(a) were all independently associated with occurrence of CAVD (P<0.05). In Pearson correlation analysis, Fetuin-A and Lp(a) were positively correlated with progression of the disease, while MGP and macrophage density were negatively correlated with it. Conclusions Fetuin-A, MPG and Lp(a) were independently associated with the occurrence of CAVD, and they might be potential predictors for diagnosis of this disease.

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“…The initial search revealed 14 studies that were potentially relevant. After a comprehensive full-text screening, nine studies were selected [ 2 , 3 , [6] , [7] , [8] , [9] , [10] , [11] , [12] ], including 3,280 patients with CAVD and 7,505 patients as controls. The Newcastle-Ottawa scale for bias assessment was utilized to determine the quality of the included studies.…”

Section: Methodsmentioning

confidence: 99%

Fetuin-A levels in association with calcific aortic valve disease: A meta-analysis

Larik

2023

Atherosclerosis Plus

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Association Between Cardiac Valvular Calcification and Serum Fetuin-A Levels in Renal Transplant Recipients

Cited by 12 publications

References 27 publications

Cardiovascular disease in the kidney transplant recipient: epidemiology, diagnosis and management strategies

Cardiovascular disease in the kidney transplant recipient: epidemiology, diagnosis and management strategies

Impact of Fetuin-A, Lp(a), matrix gla protein and macrophage density on calcific aortic valve disease: a clinical study

Fetuin-A levels in association with calcific aortic valve disease: A meta-analysis

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