Association between CASP8 –652 6N Del Polymorphism (rs3834129) and Colorectal Cancer Risk: Results from a Multi-Centric Study

Pardini, Barbara; Verderio, Paolo; Pizzamiglio, Sara; Nici, Carmela; Maiorana, Maria Valeria; Naccarati, Alessio; Vodičková, Ľudmila; Vymetalková, Veronika; Veneroni, Silvia; Daidone, Maria Grazia; Ravagnani, Fernando; Bianchi, T; Bujanda, Luís; Carracedo, Ángel; Castells, Antoni; Ruíz-Ponte, Clara; Morreau, Hans; Howarth, Kimberley; Jones, Angela; Castellví–Bel, Sergi; Li, Li; Tomlinson, Ian; Wezel, Tom van; Vodička, Pavel; Radice, Paolo; Peterlongo, Paolo

doi:10.1371/journal.pone.0085538

Cited by 8 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There were several reports examining the contribution of caspase-8 rs3834129 in CRC risk in other populations. A multicentric study that included 6,733 CRC cases and 7,576 controls recruited from Spain, Italy, USA, England, Czech Republic and the Netherlands has indicated that rs3834129 was not associated with CRC risk (37). This is consistent with the study conducted by Xiao MS et al which included 305 CRC patients and 342 healthy Chinese controls (38).…”

Section: Discussionsupporting

confidence: 84%

Contribution of Caspase-8 Genotypes to Colorectal Cancer Risk in Taiwan

Hung

Gong

et al. 2019

Anticancer Res

View full text Add to dashboard Cite

Background/Aim: The aim of this study was to examine the role of caspase-8 rs3834129 polymorphism on colorectal cancer (CRC) risk in Taiwanese CRC patients and healthy controls. Materials and Methods: The caspase-8 rs3834129 (-652 6N insertion/deletion) polymorphic genotypes were analyzed in 362 patients with CRC and the same number of age-and gender-matched healthy subjects. The interaction of caspase-8 rs3834129 genotypes with personal behaviors and clinicopathological features were also examined. Results: The percentage of variants ID and DD for caspase-8 rs3834129 genotype were 37.6 and 5.8% in CRC group and 39.0 and 6.6% in the control group, respectively (p for trend=0.7987). The allelic frequency distribution analysis showed that caspase-8 rs3834129 D allele conferred a non-significant lower susceptibility for CRC compared with I allele (OR=0.92, p=0.5063). There was no obvious link between caspase-8 rs3834129 genotype and CRC risk among ever-smokers, non-smokers, non-alcohol drinkers or alcohol drinkers. No statistically significant correlation was observed between caspase-8 rs3834129 genotypic distribution and age, gender, tumor size, location or metastasis status. Conclusion: Overall, caspase-8 rs3834129 genotypes may not serve as predictors for CRC risk or prognosis.

show abstract

Section: Discussionsupporting

confidence: 84%

Contribution of Caspase-8 Genotypes to Colorectal Cancer Risk in Taiwan

Hung

Gong

et al. 2019

Anticancer Res

View full text Add to dashboard Cite

show abstract

“…As shown in Table 1 , 18 separate studies including a total of 15,086 patients and 16,374 controls were finally retrieved. Among them, there were 3 esophageal cancer studies [12 , 15 – 16] , 3 gastric cancers [12 , 15 , 17] and 12 colorectal cancers (including studies) [15 , 18 – 23] ( Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

A meta-analysis of caspase-8 -652 6N del polymorphism and digestive tract cancer risk

Song

Fang

et al. 2019

J Biomed Res

View full text Add to dashboard Cite

Caspase-8 (CASP8) is one key regulator of apoptosis of T lymphocytes and is encoded by the CASP8 gene. It has been reported that the six-nucleotide deletion polymorphism (-652 6N del) of the CASP8 gene had effect on some cancer risk. Few studies explored the association between CASP8 gene polymorphism and digestive tract cancer risk. To evaluate the association between the CASP8 -652 6N del polymorphism and the risk of digestive tract cancer, we conducted this meta-analysis. We found that CASP8-652 6N del polymorphism was associated with a significantly reduced risk of digestive tract cancer in the co-dominant model (del/del vs. ins/ins: OR= 0.82, 95%CI= 0.72-0.95; del/ins vs. ins/ins: OR= 0.92, 95%CI= 0.87-0.97; dominant model (del/ins+ del/del vs. ins/ins: OR= 0.91, 95%CI= 0.87-0.96, recessive model: del/del vs. del/ins+ ins/ins: OR= 0.85, 95%CI= 0.75-0.97). In the stratified analysis by cancer types, we found that all genetic models had protective effect on gastric cancer. Similar results were observed for colorectal cancer under heterozygote comparison and dominant model, but not under homozygote comparison or recessive model. In addition, a significantly decreased risk was found on esophageal cancer for most genetic models, except heterozygote comparison. When stratified by ethnicity and source of control, an evidently decreased risk was identified in the Asian populations and population-based studies. In conclusion, there exists an association between the CASP8 -652 6N del polymorphism and reduced digestive cancer risk, especially among Asians and population-based studies.

show abstract

“…Further biochemical assays illustrated that this variant might lead to decreased apoptotic reactivity of T lymphocytes upon cancer cells stimulation. A multi-centric study conducted by Pardini et al indicated that rs3834129 was not associated with CRC risk in the full data set 21 . This study recruited 6,733 CRC cases and 7,576 controls by six different centers located in Spain, Italy, USA, England, Czech Republic and the Netherlands collaborating to the international consortium COGENT (Colorectal cancer GENeTics).…”

Section: Discussionmentioning

confidence: 97%

CASP8 rs3834129 (-652 6N insertion/deletion) Polymorphism and Colorectal Cancer Susceptibility: An Updated Meta-Analysis

Yin

et al. 2018

J. Cancer

View full text Add to dashboard Cite

CASP8 rs3834129 polymorphism (-652 6N insertion/deletion) is a genetic alteration which might affect the apoptosis pathway caspase enzyme. The impaired caspase enzyme would lead to the change of cancer risk. By now, the role of CASP8 rs3834129 polymorphism has been widely investigated. However, the relationship of this genetic variant on colorectal cancer (CRC) susceptibility still remains inconsistent. Therefore, we further investigated the role of rs3834129 polymorphism on CRC risk. Eligible published studies were retrieved from EMBASE, PubMed, CNKI and WANFANG database updates to March 2018. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the relationship strengths. In general, we successfully retrieved 13 studies (8 publications) involving 13058 cases and 14418 controls. The meta-analysis results demonstrated that rs3834129 polymorphism was associated with a decreased CRC risk in heterozygous model (ID vs. II: OR = 0.94, 95% CI = 0.88-0.99), but not the homozygous and allele models. Furthermore, significantly decreased risk was also found among Asian (ID vs. II: OR = 0.86, 95% CI = 0.76-0.98), and high quality score group (ID vs. II: OR = 0.90, 95% CI = 0.81-1.00) in the stratified analyses. Taken together, we showed that CASP8 rs3834129 polymorphism influences CRC susceptibility in a weak impact manner. More case-control studies are warranted to validate such relationship.

show abstract

Association between CASP8 –652 6N Del Polymorphism (rs3834129) and Colorectal Cancer Risk: Results from a Multi-Centric Study

Cited by 8 publications

References 19 publications

Contribution of Caspase-8 Genotypes to Colorectal Cancer Risk in Taiwan

Contribution of Caspase-8 Genotypes to Colorectal Cancer Risk in Taiwan

A meta-analysis of caspase-8 -652 6N del polymorphism and digestive tract cancer risk

CASP8 rs3834129 (-652 6N insertion/deletion) Polymorphism and Colorectal Cancer Susceptibility: An Updated Meta-Analysis

Contact Info

Product

Resources

About