2021
DOI: 10.2147/dmso.s284998
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Association Between CDKAL1, HHEX, CDKN2A/2B and IGF2BP2 Gene Polymorphisms and Susceptibility to Type 2 Diabetes in Uttarakhand, India

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Cited by 13 publications
(5 citation statements)
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“… 16 Moreover, a significant relationship was observed among rs10440833 and T2DM risk under the recessive model in Indian. 30 For rs10946398, our study found that CC genotype was significantly associated with the increased risk of GDM, similar to the results of Zhang et al from another Chinese populations. 23 Zhang et al found that the insulin secretion index and insulin sensitivity index of CC genotype were significantly lower than those of AA genotype as well.…”
Section: Discussionsupporting
confidence: 91%
“… 16 Moreover, a significant relationship was observed among rs10440833 and T2DM risk under the recessive model in Indian. 30 For rs10946398, our study found that CC genotype was significantly associated with the increased risk of GDM, similar to the results of Zhang et al from another Chinese populations. 23 Zhang et al found that the insulin secretion index and insulin sensitivity index of CC genotype were significantly lower than those of AA genotype as well.…”
Section: Discussionsupporting
confidence: 91%
“…Our result show rs 1111875 polymorphism there is no significant difference between controls obese and patients obese genotype in any of the codominant, dominant, recessive, and additive model's genotypes. Some studies did not match our study in Dutch Breda cohort [22] southeast Iranian [14] In Potsdam, Germany [23], while our current study was identical to the study conducted in Uttarakhand, India [24]. Another study conducted on the Thai population showed no association between rs 1111875 located near gene HHEX and T2DM [25].…”
Section: Discussioncontrasting
confidence: 46%
“…IGF2BP2 is involved in many biological processes by interacting with miRNAs, mRNAs and long non-coding RNAs to regulate various signalling pathways (16)(17). IGF2BP2 gene has been recognized to be linked with reduced secretion of insulin and B cell function (18). Genome-Wide Association Studies (GWAS) have shown that IGF2BP2 gene polymorphisms are also associated with pancreatic β-cell function and hyperglycaemia, and SNPs in the second intron of this gene are critical in the occurrence of T2D (13).…”
Section: Discussionmentioning
confidence: 99%