Association between cervical dysplasia and human papillomavirus in HIV seropositive women from Johannesburg South Africa

Firnhaber, Cynthia; Le, Hoa Van; Pettifor, Audrey; Schulze, Doreen; Michelow, Pam; Sanne, Ian; Lewis, David A.; Williamson, Anna‐Lise; Allan, Bruce; Williams, Sophia; Rinas, Allen; Levin, Simon; Smith, Jennifer S.

doi:10.1007/s10552-009-9475-z

Cited by 94 publications

(106 citation statements)

References 40 publications

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“…This data corroborate previous reports [46,47]. However, this rate is much lower than the rates reported in sub-Saharan Africa, which ranged from 49.8% to 73% [48] and India (27.5%) [15].…”

Section: Discussionsupporting

confidence: 90%

The Human papillomavirus among women living with Human Immunodeficiency Virus in Morocco A prospective cross-sectional study

Ouladlahsen¹,

Fayssel

Bensghir³

et al. 2018

J Infect Dev Ctries

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Introduction: Women infected with human immunodeficiency virus (HIV) have a higher risk of contracting human papillomavirus (HPV) infections and are more prone to develop cervical cancer. The objective of this study was to determine the prevalence of HPV and its association with risk factors among Moroccan women living with HIV/AIDS. Methodology: We enrolled 251 HIV-infected non-pregnant women in Morocco from February 2013 to September 2016. Sociodemographic, lifestyles, behavioral and clinical data were collected. Polymerase chain reaction followed by sequencing were performed for molecular detection and HPV genotyping in cervical samples, respectively. Results: Abnormal cervical smears were found in 34/246 patients (13.82%). The overall prevalence of HPV was 74.50%. HPV 58 was the most prevalent (39.29%) followed by HPV 18 (10.71%), HPV 70 (8.93%), HPV 33 (7.14%), HPV 6 (6.25%) and other genotypes (< 3%). Overall, high-risk HPV (HR-HPV) types were present in 75% (84/112) of patients and the prevalence of HR-HPV types in samples with abnormal Pap was higher than in normal Pap (55/83, 66.27% vs. 28/83,33.33%, p < 0.0001). Univariate analyses showed that none of the socio-demographic and behaviors factors was associated with HPV infection. Moreover, Pap results were not affected by HPV status (p = 0.532). Whereas, CD4 T-cell counts above 200/mm 3 at enrolment were apparently not protective to HPV infection. We found a high prevalence of HPV infection and HR-HPV types among HIV-positive women that significantly associated with abnormal Pap. Conclusion: Our findings suggest a high prevalence of HPV infection with high-risk types was observed among HIV-positive women warrant to implement a regular screening by Pap smear.

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“…This data corroborate previous reports [46,47]. However, this rate is much lower than the rates reported in sub-Saharan Africa, which ranged from 49.8% to 73% [48] and India (27.5%) [15].…”

Section: Discussionsupporting

confidence: 90%

The Human papillomavirus among women living with Human Immunodeficiency Virus in Morocco A prospective cross-sectional study

Ouladlahsen¹,

Fayssel

Bensghir³

et al. 2018

J Infect Dev Ctries

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“…HAART increases the life expectancy of women living with HIV and AIDS and therefore not only allows for increased potential exposure time to HR-HPV but also permits for accumulation of cellular genetic changes that ultimately lead to cervical cancer [15]. While some studies have shown HAART to promote clearance of HR-HPV, its effect on the incidence and progression of high-grade cytological squamous intraepithelial lesions remains controversial [25]. The introduction of HAART more than 10 years ago in Zimbabwe has not been matched with a decline in the incidence of ICC [1,26].…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus Genotypes in Invasive Cervical Carcinoma in HIV Seropositive and Seronegative Women in Zimbabwe

Mudini¹,

Palefsky²,

Hale³

et al. 2017

J Infect Dis Ther

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“…In Ahdeich Grant et al [11,12], Hanskin's [13], Firnhasen [14], and Heard et al studies [15,16], they all said that low CD4 counts and increased HIV viral loads have an independent association with the incidence of delayed clearance of HPV infections as well as with the risk of progression of SIL (squamous intra-epithelial lesions).…”

Section: Cd4 Count and Its Association With The Colposcopic Findings mentioning

confidence: 99%

Colposcopic Study of Lower Genital Tract Infections in HIV-Positive Women on Antiretroviral Therapy

Badkur

Ghanghoriya

2016

J Obstet Gynecol India

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Aims and Objectives To study the colposcopic findings and prevalence of lower genital tract infections in HIVpositive women on anti-retroviral therapy. To find correlation between colposcopic finding, m RNA HPV and cytology of lower genital tract infections in HIV-positive women on anti-retroviral therapy. Materials and Methods The present prospective observational study was conducted in the Department of Obstetrics and Gynaecology, Netaji Subhash Chandra Bose Medical College, Jabalpur, from 1 June 2013 to 31 October 2014. The data of the present study was recorded into computer and after proper validation, error checking, coding and decoding, the data was compiled and analysed using the SPSS Windows. Appropriate univariate and bivariate analysis were carried out using the Student's t test and two-tailed Fisher exact test or Chi-square test for categorical variables.

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Association between cervical dysplasia and human papillomavirus in HIV seropositive women from Johannesburg South Africa

Cited by 94 publications

References 40 publications

The Human papillomavirus among women living with Human Immunodeficiency Virus in Morocco A prospective cross-sectional study

The Human papillomavirus among women living with Human Immunodeficiency Virus in Morocco A prospective cross-sectional study

Human Papillomavirus Genotypes in Invasive Cervical Carcinoma in HIV Seropositive and Seronegative Women in Zimbabwe

Colposcopic Study of Lower Genital Tract Infections in HIV-Positive Women on Antiretroviral Therapy

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