Association Between Cervical Sagittal Alignment and Subaxial Paraspinal Muscle Parameters

Abstract

Study Design. Retrospective review of prospectively collected data. Objective. We aim to investigate the association between muscle functional group characteristics and sagittal alignment parameters in patients undergoing anterior cervical discectomy and fusion (ACDF). Summary of Background Data. The relationship between the cervical paraspinal muscles morphology and sagittal alignment is not well-understood. Methods. Patients with preoperative cervical MRIs and cervical spine lateral radiographs in standing position who underwent ACDF between 2015 and 2018 were reviewed. Radiographic alignment parameters included C2-7 lordosis, C2-7 SVA, C2 slope, neck tilt, T1 slope and thoracic inlet angle. Muscles from C3 to C7 were categorized into 4 functional groups: sternocleidomastoid group (SCM), anterior group, posteromedial group (PM), and the posterolateral group (PL). A custom-written Matlab software was used to assess the functional cross-sectional area (fCSA), and percent fat infiltration (FI) for all groups. Multivariable linear regression analyses were conducted and adjusted for age, sex, and body mass index (BMI). Results. A total of 172 patients were included. Regression analyses demonstrated that a greater C2-7 SVA was significantly associated with a greater FI of the anterior group from C3 to C5 and with a higher fCSA of the PL group at C3-C4, and C6-7. A larger C2 slope was significantly correlated with a greater FI of the anterior group at C3-C4 and a higher fCSA of the PL group from C3 to C5. Conclusion. Our work proposes new insights into the complex interaction between sagittal alignment and cervical paraspinal muscles by emphasizing the importance of these muscles in sagittal alignment. We hypothesize that with cervical degeneration, the stabilizing function of the anterior muscles decreases, which may result in an increase in the compensatory mechanism of the posterolateral muscles. Consequently, there may be a corresponding increase in the C2-C7 SVA and a larger C2 slope.