2019
DOI: 10.21037/tcr.2019.10.35
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Association between Chlamydia pneumoniae infection and lung cancer: a meta-analysis

Abstract: Background: The aim of this study is to explore the correlation between Chlamydia pneumoniae (C. pneumoniae) infection and lung carcinoma.Methods: Databases of PubMed, Embase, Embase, Ovid, Wanfang and China National Knowledge Infrastructure (CNKI) database were investigated for eligible literatures from their establishments to February, 2019. Included studies were selected according to specific eligibility criteria. Statistical analysis was performed by RevMan 5.3 software.Results: Thirteen studies with 2,553… Show more

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Cited by 7 publications
(6 citation statements)
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“…In another study, increased Chlamydia pneumoniae-specific IgA levels in smokers with lung cancer were found [ 24 ]. A mata analysis that included 13 studies, 2553 lung cancer cases and 2460 controls showed that chlamydia pneumoniae infection was significantly associated with the risk of lung cancer, with IgA infection having a 3.19 times greater risk than negative titers (95% CI: 1.96–5.19), the risk of IgG infection was 2.02 times that of negative titers (95% CI: 1.29–3.16) [ 25 ]. To verify the relationship between Mycoplasma pneumoniae and lung cancer, more research work is needed to gain insight into the relationship between Cpn infection and primary lung cancer, and to develop more effective prevention and treatment strategies to improve the quality of life of lung cancer patients.To our knowledge, this is the first prospective study to explore the relationship between Cpn infection and HRQoL based on the TTD model.…”
Section: Discussionmentioning
confidence: 99%
“…In another study, increased Chlamydia pneumoniae-specific IgA levels in smokers with lung cancer were found [ 24 ]. A mata analysis that included 13 studies, 2553 lung cancer cases and 2460 controls showed that chlamydia pneumoniae infection was significantly associated with the risk of lung cancer, with IgA infection having a 3.19 times greater risk than negative titers (95% CI: 1.96–5.19), the risk of IgG infection was 2.02 times that of negative titers (95% CI: 1.29–3.16) [ 25 ]. To verify the relationship between Mycoplasma pneumoniae and lung cancer, more research work is needed to gain insight into the relationship between Cpn infection and primary lung cancer, and to develop more effective prevention and treatment strategies to improve the quality of life of lung cancer patients.To our knowledge, this is the first prospective study to explore the relationship between Cpn infection and HRQoL based on the TTD model.…”
Section: Discussionmentioning
confidence: 99%
“…Instead, we herein review the research progress made in H. pylori [ 20 ], S. pneumoniae [ 21 ], M.tb [ 22 ], and C. pneumoniae [ 23 ], which have been reported to be involved in lung cancer development and are not typically recognized as a subject in the research of the human microbiome and lung cancer, although H. pylori and S. pneumoniae are part of the commensal bacterial flora [ 56 , 57 ]. Consequently, this part of the review aims to inspire people to introduce the concept of biological pollutants in investigations of the microbiome and lung cancer, and to elucidate the relationship between biological hazards and human microbiota.…”
Section: Bacteria and Lung Cancermentioning
confidence: 99%
“…C. pneumoniae is a Gram-negative bacterium that is a common respiratory pathogen causing chronic and persistent respiratory infections [ 80 ]. Studies have shown that C. pneumoniae infection significantly increases the risk of lung cancer [ 23 , 81 , 82 , 83 , 84 ]. Although the mechanisms underlying C. pneumoniae -promoted lung cancer are still unknown, chronic inflammation caused by C. pneumoniae infection is inextricably linked to the development of lung cancer.…”
Section: Bacteria and Lung Cancermentioning
confidence: 99%
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“…It has been found that IgA antibodies were increased in lung cancer patients infected with Chlamydia pneumoniae (Koyi et al 2001). In another study, increased Chlamydia pneumoniaespeci c IgA levels in smokers with lung cancer were found (Paldanius et al 2003).A mata analysis that included 13 studies, 2553 lung cancer cases and 2460 controls showed that chlamydia pneumoniae infection was signi cantly associated with the risk of lung cancer, with IgA infection having a 3.19 times greater risk than negative titers (95% CI: 1.96-5.19), the risk of IgG infection was 2.02 times that of negative titers (95% CI: 1.29-3.16) (Wang et al 2019). To verify the relationship between Mycoplasma pneumoniae and lung cancer, more research work is needed to gain insight into the relationship between Cpn infection and primary lung cancer, and to develop more effective prevention and treatment strategies to improve the quality of life of lung cancer patients.To our knowledge, this is the rst prospective study to explore the relationship between Cpn infection and HRQoL based on the TTD model.…”
Section: The Relationship Between Ttd and Cpn Antibodymentioning
confidence: 99%