Association between Chronic Apical Periodontitis and Low-birth-weight Preterm Births

Leal, Alex Sandro Mendonça; Oliveira, Ana Emília Figueiredo de; Brito, Luciane Maria Oliveira; Lopes, Fernanda Ferreira; Rodrigues, Vandílson Pinheiro; Lima, Karinna Fróes; Martins, Illana Catharine de Araújo

doi:10.1016/j.joen.2014.11.018

Cited by 20 publications

(32 citation statements)

References 37 publications

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“…2012, Leal et al . 2015, Poyato‐Borrego et al . 2019); only one study was a real case–control, in which the AP was the predictor (Khalighinejad et al .…”

Section: Discussionmentioning

confidence: 99%

The global prevalence of apical periodontitis: a systematic review and meta‐analysis

Michelon²,

et al. 2021

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“…2012, Leal et al . 2015, Poyato‐Borrego et al . 2019); only one study was a real case–control, in which the AP was the predictor (Khalighinejad et al .…”

Section: Discussionmentioning

confidence: 99%

The global prevalence of apical periodontitis: a systematic review and meta‐analysis

Michelon²,

et al. 2021

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“…Percentage of apoptotic cells was increased in CRP‐stimulated human umbilical vein endothelial cells (HUVECs) (Guo et al , ). Periodontitis was also associated with low birthweight (Leal et al , ). Li et al () found that LPS isolated from Aa could upregulate the expression of cytochrome c and caspase‐2, caspase‐3, and caspase‐9 in primary human placental trophoblast‐like BeWo cells, which was accompanied by decrease in Bcl‐2 levels, suggesting that Aa ‐induced apoptosis was mitochondrion dependent.…”

Section: Introductionmentioning

confidence: 99%

Programmed cell death in periodontitis: recent advances and future perspectives

et al. 2016

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Periodontitis is a highly prevalent infectious disease, characterized by destruction of the periodontium, and is the main cause of tooth loss. Periodontitis is initiated by periodontal pathogens, while other risk factors including smoking, stress, and systemic diseases aggravate its progression. Periodontitis affects many people worldwide, but the molecular mechanisms by which pathogens and risk factors destroy the periodontium are unclear. Programmed cell death (PCD), different from necrosis, is an active cell death mediated by a cascade of gene expression events and can be mainly classified into apoptosis, autophagy, necroptosis, and pyroptosis. Although PCD is involved in many inflammatory diseases, its correlation with periodontitis is unclear. After reviewing the relevant published articles, we found that apoptosis has indeed been reported to play a role in periodontitis. However, the role of autophagy in periodontitis needs further verification. Additionally, implication of necroptosis or pyroptosis in periodontitis remains unknown. Therefore, we recommend future studies, which will unravel the pivotal role of PCD in periodontitis, allowing us to prevent, diagnose, and treat the disease, as well as predict its outcomes.

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“…After 49 duplicates were removed, 470 studies were excluded, while four were eligible for full‐text assessment. Finally, one study was excluded because the outcomes studied were placental and systemic markers rather than adverse pregnancy complications (Harjunmaa et al, 2018), while three studies were included in the current review (Harjunmaa et al, 2015; Khalighinejad et al, 2017; Leal et al, 2015). The characteristics of the included clinical studies are described in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…As apical periodontitis is not just a local event, it was reasonable to investigate whether generalized low‐grade inflammation and/or bloodstream infection could potentially contribute to APOs. Notably, the findings of the existing primary studies appear inconsistent (Harjunmaa et al, 2015; Khalighinejad et al, 2017; Leal et al, 2015); however, the association of APOs and apical periodontitis has not been examined rigorously or reviewed. Therefore, this systematic review aimed to critically evaluate the available evidence on the association of maternal apical periodontitis with several APOs.…”

Section: Introductionmentioning

confidence: 99%

The association between apical periodontitis and adverse pregnancy outcomes: a systematic review

Jakovljević

Jakovljević²,

Duncan

et al. 2021

Int Endodontic J

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Background The association between adverse pregnancy outcomes (APOs) and maternal apical periodontitis remains unclear as it has not been examined rigorously or reviewed systematically. Objective To systematically review and critically evaluate the available evidence on the association of maternal apical periodontitis with several APOs. Methods A literature search was conducted using the following electronic databases: Clarivate Analytics’ Web of Science, Scopus, PubMed, and Cochrane Central Register of Controlled Trials (CENTRAL), from inception to 25 February 2021, with no language restrictions. Observational studies including longitudinal clinical trials, cohort, case–control and cross‐sectional studies of prospective and retrospective design were included. Articles with duplicate or overlapping results, abstract‐only papers, case reports, case series, animal studies and reviews were excluded. Two independent reviewers were involved in study selection, data extraction and appraising the included studies; disagreements were resolved by a third reviewer. The Newcastle–Ottawa Scale (NOS) and the adapted form of the NOS were used to assess the quality for case–control and cross‐sectional studies, respectively. Results Two case–control and one cross‐sectional study were included in the current review. The included studies were published between 2015 and 2017, with a total of 1187 participating individuals with an approximate age range of 15 to 40 years. As the included studies reported different outcomes, the heterogeneity of data prevented a meta‐analysis being undertaken. The overall quality of the evidence was ‘Fair’ for two out of three included studies, while one study was categorized as ‘Good’. Discussion Two out of three included primary studies had a substantial number of methodological inconsistencies and flaws, and therefore caution should be exercised in interpreting the results of this systematic review because several important covariates were not considered in the original investigations. Conclusion Based on a limited volume and ‘Fair’ and ‘Good’ quality of evidence, a positive association between maternal apical periodontitis and APOs was observed. However, more ‘Good’ quality clinical studies are needed to confirm the results of the current review. Funding None Registration PROSPERO database (CRD42‐2191987)

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Association between Chronic Apical Periodontitis and Low-birth-weight Preterm Births

Cited by 20 publications

References 37 publications

The global prevalence of apical periodontitis: a systematic review and meta‐analysis

The global prevalence of apical periodontitis: a systematic review and meta‐analysis

Programmed cell death in periodontitis: recent advances and future perspectives

The association between apical periodontitis and adverse pregnancy outcomes: a systematic review

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